1. Predictive factors of non-operative management failure in 494 blunt liver injuries: a multicenter retrospective study
- Author
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Mathieu Rouy, Clément Julien, Ilyes Hamouda, Damien Massalou, Thierry Bege, Marc Leone, Stephane Berdah, Sandrine Barbois, Edouard Girard, Catherine Arvieux, David Jérémie Birnbaum, Équipe de droit international, européen et comparé (EDIEC), Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon, Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Emergency surgery, CHU Nice, Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel, Université Côte d'Azur (UCA), CHU Marseille, Hôpital Nord [CHU - APHM], Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois], Centre Hospitalier Universitaire [Grenoble] (CHU), and Assistance Publique - Hôpitaux de Marseille (APHM)
- Subjects
Liver ,Hemoperitoneum ,Humans ,Surgery ,Prospective Studies ,Wounds, Nonpenetrating ,Retrospective Studies ,[SHS]Humanities and Social Sciences - Abstract
Non-operative management (NOM) has become the major treatment of blunt liver trauma (BLT) with a NOM failure rate of 3-15% due to liver-related complications. The aim of the study was to determine the predictive factors and a risk-stratified score of NOM failure. From 2013 to 2021, all patients with BLT in three trauma centers were included; clinical, biological, radiological and outcome data were retrospectively analyzed. Predictive factors and a risk-stratified score associated with NOM failure were identified. Four hundred and ninety-four patients with BLT were included. Among them, 80 (16.2%) had isolated BLT. Fifty-nine patients (11.9%) underwent emergent operative management (OM) on the day of admission and 435 (88.1%) had a NOM. NOM failure rate was 11.5%. Patients with a NOM failure more frequently had a hemoperitoneum (p 0.001), liver bleeding (p 0.001), blood transfusion (p 0.001) and angioembolization (p 0.001) compared to patient with a successful NOM. In multivariate analysis, the presence of hemoperitoneum (OR = 5.71; 95 CI [1.29-25.45]), angioembolization (OR = 8.73; 95 CI [2.04-38.44] and severe liver injury (AAST IV or V) (OR = 8.97; 95 CI [3.36-23.99]) were independent predictive factors of NOM failure. When these three factors were associated, NOM failure rate was 83.3%. The AAST grade, the presence of hemoperitoneum and the realization of liver angioembolization on the day of admission are three independent predictive factors of NOM failure. Our risk-score based on these three factors stratify the risk of NOM failure in BLT and could be used for a more appropriate level of medical survey adapted to each patient. Level of evidence: prospective observational cohort study, Level III.
- Published
- 2022
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