Search

Your search keyword '"Boccardi E"' showing total 12 results
Start Over Author "Boccardi E" Topic surgery
12 results on '"Boccardi E"'

1. Cranial nerve deficits in giant cavernous carotid aneurysms and their relation to aneurysm morphology and location

Author

Durner, G, Piano, M, Lenga, P, Mielke, D, Hohaus, C, Guhl, S, Maldaner, Nicolai, Burkhardt, J K, Pedro, M T, Lehmberg, J, Rufenacht, D, Bijlenga, P, Etminan, N, Krauss, J K, Boccardi, E, Hänggi, D, Vajkoczy, P, Dengler, Julius, Giant Intracranial Aneurysm Study Group, University of Zurich, and Dengler, Julius

Subjects
Aneurysm volume, Partial thrombosis, 10180 Clinic for Neurosurgery, 2728 Neurology (clinical), Cavernous carotid aneurysm, Clinical Neurology, 610 Medicine & health, Surgery, Giant intracranial aneurysms, 2746 Surgery
Published
2018

2. Outcome of Surgical or Endovascular Treatment of Giant Intracranial Aneurysms, with Emphasis on Age, Aneurysm Location, and Unruptured Aneuryms - A Systematic Review and Meta-Analysis

Author

Dengler, Julius, Maldaner, Nicolai, Maldaner, N., van der Zwan, A., van Doormaal, T., Cognard, C., Gawlitza, M., Walter, J., Kalff, R., Fiedler, J., Uebelacker, A., Dengler, J., Bohner, G., Wiener, E., Bauknecht, H. C., Heuschmann, P. U., Malzahn, U., Gläsker, S., Zentner, J., Gläsker, Sven, Van Velthoven, V., Guhl, S., Schroeder, H. W. S., Strowitzki, M., Etminan, N., Haengghi, D., Eicker, S., Turowski, B., Schebesch, K. M., Brawanski, A., Endres, Matthias, Wrede, K., Sure, U., Schmidt, N. O., Regelsberger, J., Westphal, M., Mielke, D., Rohde, V., Hosch, H., Moskopp, D., Joedicke, A., Wagner, Martin, Hohaus, C., Meisel, H. J., Wostrack, M., Meyer, B., Lehmberg, J., Musahl, C., Hopf, N., Winkler, G., Spetzger, U., Graewe, A., Malzahn, Uwe, Meier, U., Hong, B., Nakamura, M., Krauss, J., Grote, A., Simon, M., Schramm, J., Kursumovic, A., Rath, S. A., Marbacher, S., Heuschmann, Peter U, Fathi, A., Fandino, J., Familiari, P., Raco, A., Bijlenga, P., Schaller, K., Gruber, A., Wang, W. T., Knosp, E., Hoffmann, K. T., Vajkoczy, Peter, Boxhammer, E., Rüfenacht, D. A., Wanke, I., Boccardi, E., Piano, M., Niemelä, M., Nurminen, V., Lehecka, M., Hernesniemi, J., Burkhardt, J. K., Group, Giant Intracranial Aneurysm Study, Bozinov, O., Regli, L., Shekhtman, O. D., Eliava, S. S., Kato, N., Irie, K., Nishimura, K., Kaku, S., Arakawa, H., Yuki, I., Vajkoczy, P., Ishibashi, T., Murayama, Y., Fiss, I., Kombos, T., Pedro, M. T., König, R., Wirtz, R., Brand, C., Hagel, V., Helthuis, J., Surgical clinical sciences, University of Zurich, and Dengler, Julius

Subjects
methods [Embolization, Therapeutic], medicine.medical_treatment, Review, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Medicine, Giant intracranial aneurysm, Embolization, Research Support, Non-U.S. Gov't, surgery [Intracranial Aneurysm], Embolization, Therapeutic, 2728 Neurology (clinical), Treatment Outcome, Neurology, Endovascular procedures, Meta-analysis, Internal carotid artery, Therapeutic, Cardiology and Cardiovascular Medicine, Carotid Artery, Internal, medicine.medical_specialty, pathology [Intracranial Aneurysm], Surgical aneurysm treatment, MEDLINE, 610 Medicine & health, surgery [Carotid Artery, Internal], 2705 Cardiology and Cardiovascular Medicine, 03 medical and health sciences, 10180 Clinic for Neurosurgery, Aneurysm, medicine.artery, Humans, Endovascular treatment, ddc:610, Retrospective Studies, business.industry, Retrospective cohort study, Intracranial Aneurysm, medicine.disease, Internal, Surgery, ddc:616.8, Clinical trial, meta-analysis, pathology [Carotid Artery, Internal], 2808 Neurology, Endovascular Procedures, Neurology (clinical), Carotid Artery, business, 030217 neurology & neurosurgery, methods [Endovascular Procedures]
Abstract

Background: Designing treatment strategies for unruptured giant intracranial aneurysms (GIA) is difficult as evidence of large clinical trials is lacking. We examined the outcome following surgical or endovascular GIA treatment focusing on patient age, GIA location and unruptured GIA. Methods: Medline and Embase were searched for studies reporting on GIA treatment outcome published after January 2000. We calculated the proportion of good outcome (PGO) for all included GIA and for unruptured GIA by meta-analysis using a random effects model. Results: We included 54 studies containing 64 study populations with 1,269 GIA at a median follow-up time (FU-T) of 26.4 months (95% CI 10.8-42.0). PGO was 80.9% (77.4-84.4) in the analysis of all GIA compared to 81.2% (75.3-86.1) in the separate analysis of unruptured GIA. For each year added to patient age, PGO decreased by 0.8%, both for all GIA and unruptured GIA. For all GIA, surgical treatment resulted in a PGO of 80.3% (95% CI 76.0-84.6) compared to 84.2% (78.5-89.8, p = 0.27) after endovascular treatment. In unruptured GIA, PGO was 79.7% (95% CI 71.5-87.8) after surgical treatment and 84.9% (79.1-90.7, p = 0.54) after endovascular treatment. PGO was lower in high quality studies and in studies presenting aggregate instead of individual patient data. In unruptured GIA, the OR for good treatment outcome was 5.2 (95% CI 2.0-13.0) at the internal carotid artery compared to 0.1 (0.1-0.3, p < 0.1) in the posterior circulation. Patient sex, FU-T and prevalence of ruptured GIA were not associated with PGO. Conclusions: We found that the chances of good outcome after surgical or endovascular GIA treatment mainly depend on patient age and aneurysm location rather than on the type of treatment conducted. Our analysis may inform future research on GIA.

Published
2016

3. Perianeurysmal edema in giant intracranial aneurysms in relation to aneurysm location, size, and partial thrombosis

Author

Dengler, Julius, Maldaner, Nicolai, Bijlenga, Philippe, Burkhardt, Jan-Karl, Graewe, Alexander, Guhl, Susanne, Hong, Bujung, Hohaus, Christian, Kursumovic, Adisa, Mielke, Dorothee, Schebesch, Karl-Michael, Wostrack, Maria, Rufenacht, Daniel, Vajkoczy, Peter, Schmidt, Nils Ole, Vajkoczy, P, Maldaner, N, Uebelacker, A, Dengler, J, Endres, M, Bohner, G, Wiener, E, Bauknecht, H C, Heuschmann, P U, Malzahn, U, Gläsker, S, Zentner, J, Van Velthoven, V, Guhl, S, Schroeder, Werner, Strowitzki, M, Etminan, N, Haengghi, D, Eicker, S, Turowski, B, Schebesch, K M, Brawanski, A, Wrede, Karsten, Sure, Ulrich, Schmidt, N O, Regelsberger, J, Westphal, M, Mielke, D, Rohde, V, Hosch, H, Moskopp, D, Joedicke, A, Hohaus, C, Meisel, H J, Wostrack, M, Meyer, B, Lehmberg, J, Musahl, C, Hopf, N, Winkler, G, Spetzger, U, Graewe, A, Meier, U, Hong, B, Nakamura, M, Krauss, J, Grote, A, Simon, M, Schramm, J, Kursumovic, A, Rath, S A, Marbacher, S, Fathi, A, Fandino, J, Familiari, P, Raco, A, Bijlenga, P, Schaller, K, Gruber, A, Wang, W T, Knosp, E, Hoffmann, K T, Boxhammer, E, Rüfenacht, Daniel, Boccardi, E, Piano, M, Niemelä, M, Nurminen, V, Lehecka, M, Hernesniemi, J, Burkhardt, J K, Bozinov, O, Regli, L, Shekhtman, O D, Eliava, S S, Kato, N, Irie, K, Nishimura, K, Kaku, S, Arakawa, H, Yuki, I, Ishibashi, T, Murayama, Y, Fiss, I, Kombos, T, Pedro, M T, König, R, Wirtz, R, Helthuis, J, van der Zwan, A, Cognard, C, Gawlitza, M, Wanke, Isabel, Fiedler, J, Surgical clinical sciences, University of Zurich, and Dengler, Julius

Subjects
Aneurysm volume, Adult, Male, medicine.medical_specialty, animal structures, Perianeurysmal edema, Clinical Neurology, Medizin, 610 Medicine & health, Brain Edema, Giant intracranial aneurysm, Partially thrombosed aneurysm, Vascular disorders, Aged, Female, Humans, Intracranial Aneurysm, Magnetic Resonance Imaging, Middle Aged, Retrospective Studies, Thrombosis, Surgery, Medicine (all), Neurology (clinical), Imaging data, 10180 Clinic for Neurosurgery, Aneurysm, medicine.artery, Edema, medicine, 10. No inequality, medicine.diagnostic_test, business.industry, Research Support, Non-U.S. Gov't, Magnetic resonance imaging, medicine.disease, 2746 Surgery, ddc:616.8, Giant Intracranial Aneurysm, 2728 Neurology (clinical), Middle cerebral artery, Radiology, Internal carotid artery, medicine.symptom, business, Partial thrombosis
Abstract

OBJECT The underlying mechanisms causing intracranial perianeurysmal edema (PAE) are still poorly understood. Since PAE is most frequently observed in giant intracranial aneurysms (GIAs), the authors designed a study to examine the occurrence of PAE in relation to the location, size, and partial thrombosis (PT) of GIAs along with the clinical impact of PAE. METHODS Magnetic resonance imaging data for patients with a diagnosis of unruptured GIA from the international multicenter Giant Intracranial Aneurysm Registry were retrospectively analyzed with regard to location and size of the GIA, PAE volume, and the presence of PT. The occurrence of PAE was correlated to clinical findings. RESULTS Imaging data for 69 GIAs were eligible for inclusion in this study. Perianeurysmal edema was observed in 33.3% of all cases, with the highest frequency in GIAs of the middle cerebral artery (MCA; 68.8%) and the lowest frequency in GIAs of the cavernous internal carotid artery (ICA; 0.0%). Independent predictors of PAE formation were GIA volume (OR 1.13, p = 0.02) and the occurrence of PT (OR 9.84, p = 0.04). Giant intracranial aneurysm location did not predict PAE occurrence. Giant aneurysms with PAE were larger than GIAs without PAE (p < 0.01), and GIA volume correlated with PAE volume (rs = 0.51, p = 0.01). Perianeurysmal edema had no influence on the modified Rankin Scale score (p = 0.30 or the occurrence of aphasia (p = 0.61) or hemiparesis (p = 0.82). CONCLUSIONS Perianeurysmal edema was associated with GIA size and the presence of PT. As no PAE was observed in cavernous ICA aneurysms, even though they exerted mass effect on the brain and also displayed PT, the dura mater may serve as a barrier protecting the brain from PAE formation.

Published
2015

4. Surpass flow diverter in the treatment of intracranial aneurysms: a prospective multicenter study

Author

Wakhloo, A.K., Lylyk, P., De Vries, J., Taschner, C., Lundquist, J., Biondi, A., Hartmann, M., Szikora, I., Pierot, L., Sakai, N., Imamura, H., Sourour, N., Rennie, I., Skalej, M., Beuing, O., Bonafé, A., Mery, F., Turjman, F., Brouwer, P., Boccardi, E., Valvassori, L., Derakhshani, S., Litzenberg, M.W., Gounis, M.J., Study Group, Surpass, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hôpital Maison Blanche, Centre Hospitalier Universitaire de Reims (CHU Reims), Service de Neuroradiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Département de Neuroradiologie[Montpellier], Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL), and Radiology & Nuclear Medicine

Subjects
Male, medicine.medical_specialty, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, medicine.medical_treatment, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Aneurysm, Blood vessel prosthesis, Occlusion, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Embolization, cardiovascular diseases, Prospective cohort study, Intraparenchymal hemorrhage, Stroke, Aged, Aged, 80 and over, Interventional, medicine.diagnostic_test, business.industry, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Intracranial Aneurysm, Middle Aged, medicine.disease, Embolization, Therapeutic, Blood Vessel Prosthesis, Cerebral Angiography, 3. Good health, Surgery, Treatment Outcome, Angiography, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

Item does not contain fulltext BACKGROUND AND PURPOSE: Incomplete occlusion and recanalization of large and wide-neck brain aneurysms treated by endovascular therapy remains a challenge. We present preliminary clinical and angiographic results of an experimentally optimized Surpass flow diverter for treatment of intracranial aneurysms in a prospective, multicenter, nonrandomized, single-arm study. MATERIALS AND METHODS: At 24 centers, 165 patients with 190 intracranial aneurysms of the anterior and posterior circulations were enrolled. The primary efficacy end point was the percentage of intracranial aneurysms with 100% occlusion on 6-month DSA. The primary safety end point was neurologic death and any stroke through a minimum follow-up of 6 months. RESULTS: Successful flow-diverter delivery was achieved in 161 patients with 186 aneurysms (98%); the mean number of devices used per aneurysm was 1.05. Clinical follow-up (median, 6 months) of 150 patients (93.2%), showed that the primary safety end point occurred in 18 subjects. Permanent neurologic morbidity and mortality were 6% and 2.7%, respectively. Morbidity occurred in 4% and 7.4% of patients treated for aneurysms of the anterior and posterior circulation, respectively. Neurologic death during follow-up was observed in 1.6% and 7.4% of patients with treated intracranial aneurysms of the anterior and posterior circulation, respectively. Ischemic stroke at 30 days or SAH at >7 days occurred. New or worsening cranial nerve deficit was observed in 2.7%. Follow-up angiography available in 158 (86.8%) intracranial aneurysms showed 100% occlusion in 75%. CONCLUSIONS: Clinical outcomes of the Surpass flow diverter in the treatment of intracranial aneurysms show a safety profile that is comparable with that of stent-assisted coil embolization. Angiographic results showed a high rate of intracranial aneurysm occlusion.

Published
2015

5. Intra-arterial or intravenous thrombolysis for acute ischemic stroke? The SYNTHESIS pilot trial

Author

Ciccone, A, Valvassori, L, Ponzio, M, Ballabio, E, Gasparotti, R, Sessa, M, Tiraboschi, P, Sterzi, R, Candelise, L, Del Zoppo, G, Sandercock, P, Cantisani, T, Coppola, C, Gatti, A, Guccione, A, Santilli, I, Jann, S., Protti, A., Rizzone, Mario Giorgio, Boccardi, E, Guidotti, M., Checcarelli, N, Muscia, F, Martegani, A, Magoni, M., Costa, A., Pavia, M, and Scomazzoni, F.

Subjects
Male, thrombolysis, Time Factors, ischemic stroke, randomized controlled trial, medicine.medical_treatment, Pilot Projects, law.invention, Brain Ischemia, Randomized controlled trial, law, Intra arterial, Medicine, Humans, Infusions, Intra-Arterial, Thrombolytic Therapy, Thrombus, Adverse effect, Infusions, Intravenous, Acute ischemic stroke, Aged, business.industry, Pilot trial, General Medicine, Thrombolysis, Middle Aged, medicine.disease, Stroke, Survival Rate, Treatment Outcome, Anesthesia, Tissue Plasminogen Activator, Ischemic stroke, Feasibility Studies, Surgery, Female, Neurology (clinical), business, Follow-Up Studies
Abstract

OBJECTIVE To assess the feasibility, safety and preliminary efficacy of intra-arterial thrombolysis (IAT) compared with standard intravenous thrombolysis (IVT) for acute ischemic stroke. METHODS Eligible patients with ischemic stroke, who were devoid of contraindications, started IVT within 3 h or IAT as soon as possible within 6 h. Patients were randomized within 3 h of onset to receive either intravenous alteplase, in accordance with the current European labeling, or up to 0.9 mg/kg intra-arterial alteplase (maximum 90 mg), over 60 min into the thrombus, if necessary with mechanical clot disruption and/or retrieval. The purpose of the study was to determine the proportion of favorable outcome at 90 days. Safety endpoints included symptomatic intracranial hemorrhage (SICH), death and other serious adverse events. RESULTS 54 patients (25 IAT) were enrolled. Median time from stroke onset to start to treatment was 3 h 15 min for IAT and 2 h 35 min for IVT (p

Published
2009

6. Unruptured Aneurysms Italian Study (UAIS) background and method

Author

Versari, P., Tartara, F., Scerrati, M., Caroselli, G., Pasquini, U., Ciappetta, P., Vailati, G., Occhiogrosso, M., Biroli, F., Bonaldi, G., Calbucci, F., Andreoli, A., Leopardi, M., Raff, L., Bollati, A., Gasparotti, R., Martellotto, N., Distefano, G., Pinna, G., Francaviglia, N., Ventura, F., Orazio, G., Cristaudo, C., Consoli, V., Nicoletti, G., Albanese, V., Ceccotti, C., Frattarelli, M., Servadei, F., Cremonini, A. M., Taborelli, A., Corriero, G., Galli, G., Morandini, A., Medina, M., Padovani, R., Farneti, M., Ghadirpour, R., Dilorenzo, N., Mennonna, P., Ammannati, F., Mangiafico, S., Celerini, M., Paoli, L., Andrioli, G., Zerbi, D., Spaziante, R., Pau, A., Stefani, F., Zona, G. L., Castellan, L., Cantore, G., Innocenzi, G., Galzio, R., Ricci, A., Montinaro, A., Cantisani, P., Arena, O., Tonnarelli, G. P., Gagliardi, R., Benvenuti, L., Tomasello, F., Paterniti, S., Trincia, G., Conti, C., Broggi, G., Giombini, S., Solero, C. L., Marras, C., Todaro, C., Ciceri, E., Fornari, M., Desantis, A., Cardia, A., Ortolina, A., Rodriguez, R., Gaetani, P., Collice, M., D Aliberti, G., Talamonti, G., Lacamera, A., Boccardi, E., Villani, R., Gaini, S., Miserocchi, G., Branca, V., Giovanelli, M., Cenzato, M., Scotti, G., Merli, A., Piazza, P., Sganzerla, E., Profeta, G., Daniele, B., Monsignore, R., Cioffi, F., Rotondo, M., Natale, M., Dedivitiis, E., Maiuri, F., Francesco BRIGANTI, Franco, A., Apolito, R., Delehaye, L., Sossio, C., Bellotti, C., Car, P. G., Benvenuto, F., Scienza, R., Berlucchi, S., Pavesi, G., Fiore, D., Laseta, F., Filizzolo, F., Fiumara, E., Tumbiolo, S., Benericetti, E., Sacchelli, A., Arienta, C., Zappoli, F., Buoncristiani, P., Buonaguidi, R., Bianchini, E., Boccardo, M., Valsania, V., Bruzzone, L., Cantini, L. R., Marconi, F., Parenti, G. F., Liberti, G., Severino, P., Delitala, A., Cotroneo, E., Gazzeri, G., Fiume, D., Esposito, S., Agrillo, U., Sidoti, C., Maira, G., Vignati, A., Marchese, E., Delfini, R., Guidetti, G., Bufatti, P., Strabella, G., D Angelo, V., Monte, V., Florio, F., Olivieri, G., Palma, L., Serchi, E., Fontana, R., Resta, M., Faccani, G., Musso, C., Ducati, A., Bradac, G. B., Longatti, P., Tacconi, L., Skrap, M., Nicassio, N., Graziussi, G., Migliaccio, N., Puglisi, A., Tomei, G., Bonfanti, N., Tabano, A., Bricolo, A., Pasqualin, A., Beltramello, A., Colombo, F., Causin, F., and Perini, S.

Subjects
Embolization, Endovascular surgical procedures, Surgery, Cerebral aneurysms, Neurology (clinical), Surgical clipping, Cerebral aneurysms, Embolization

7. Italian multicenter experience with flow-diverter devices for intracranial unruptured aneurysm treatment with periprocedural complications-a retrospective data analysis

Author

Rosario Papa, Lucio Castellan, Giovanni Sirabella, Maurizio Isalberti, Salvatore Mangiafico, Roberto Gasparotti, Domenico Solari, Nunzio Paolo Nuzzi, Francesco Di Paola, Edoardo Boccardi, Maurizio Resta, Andrea Fontana, Fernando Lupo, Andrea Manto, Roberto Menozzi, Francesco Causin, Mario Muto, Benedetto Petralia, Elisa Ciceri, M. Napoli, Riccardo Padolecchia, Giuseppe Iannucci, Marco Leonardi, Roberto De Blasi, Luca Piero Valvassori Bolgè, Giulio Guidetti, Ignazio Divenuto, Mauro Bergui, Luigi Cirillo, Mariangela Piano, Fabio Tortora, Andrea Saletti, Francesco Briganti, Enrico Cagliari, Luigi Delehaye, Briganti, F, Napoli, M, Tortora, Fabio, Solari, D, Bergui, M, Boccardi, E, Cagliari, E, Castellan, L, Causin, F, Ciceri, E, Cirillo, L, De Blasi, R, Delehaye, L, Di Paola, F, Fontana, A, Gasparotti, R, Guidetti, G, Divenuto, I, Iannucci, G, Isalberti, M, Leonardi, M, Lupo, F, Mangiafico, S, Manto, A, Menozzi, R, Muto, M, Nuzzi, Np, Papa, R, Petralia, B, Piano, M, Resta, M, Padolecchia, R, Saletti, A, Sirabella, G, Bolgè, L. P., Briganti F, Napoli M, Tortora F, Solari D, Bergui M, Boccardi E, Cagliari E, Castellan L, Causin F, Ciceri E, Cirillo L, De Blasi R, Delehaye L, Di Paola F, Fontana A, Gasparotti R, Guidetti G, Divenuto I, Iannucci G, Isalberti M, Leonardi M, Lupo F, Mangiafico S, Manto A, Menozzi R, Muto M, Nuzzi NP, Papa R, Petralia B, Piano M, Resta M, Padolecchia R, Saletti A, Sirabella G, Bolgè LP., Briganti, Francesco, Napoli, M., Tortora, F., Solari, D., Bergui, M., Boccardi, E., Cagliari, E., Castellan, L., Causin, F., Ciceri, E., Cirillo, L., Blasi, R. D., Delehaye, L., Paola, F. D., Fontana, A., Gasparotti, R., Guidetti, G., Divenuto, I., Iannucci, G., Isalberti, M., Leonardi, M., Lupo, F., Mangiafico, S., Manto, A., Menozzi, R., Muto, M., Nuzzi, N. P., Papa, R., Petralia, B., Piano, M., Resta, M., Padolecchia, R., Saletti, A., Sirabella, G., and Valvassori, L. P.

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Flow diverter device, Intracranial aneurysms, Comorbidity, Aneurysm, Ruptured, Retrospective data, ANEURISMS, FLOW DIVERTER, Postoperative Complications, Risk Factors, medicine, Humans, Radiology, Nuclear Medicine and imaging, Endovascular treatment, cardiovascular diseases, Embolization, Neuroradiology, Flow diverter, Aged, Retrospective Studies, business.industry, Incidence, Pipeline embolization device, Middle Aged, Intracranial aneurysm, Survival Analysis, Surgery, Blood Vessel Prosthesis, Survival Rate, Silk embolization device, Treatment Outcome, Italy, Unruptured aneurysm, Female, Stents, Neurology (clinical), Neurosurgery, Radiology, Cardiology and Cardiovascular Medicine, business
Abstract

INTRODUCTION: We report the experiences of 25 Italian centers, analyzing intra- and periprocedural complications of endovascular treatment of intracranial aneurysms using Silk (Balt Extrusion, Montmorency, France) and pipeline embolization devices (EV3 Inc, Irvine California). METHODS: Two hundred seventy-three patients with 295 cerebral aneurysms, enrolled in 25 centers in Italy and treated with the new flow-diverter devices, were evaluated; 142 patients were treated with Silk and 130 with pipeline (in one case, both devices were used). In 14 (5.2 \%) cases devices were used with coils. Aneurysm size was >15 mm in 46.9 \%, 5-15 mm in 42.2 \%, and

Published
2012

8. Long-term follow-up of the DERIVO® Embolization Device (DED®) for intracranial aneurysms: The Italian Multicentric Registry

Author

Giuseppe Faragò, C Princiotta, Paolo Cerini, Giuseppe Lucente, Simone Peschillo, Maurizio De Nicola, Luca Quilici, Lucio Castellan, Luigi Chiumarulo, Nicola Limbucci, Nevia Caputo, Maria Ruggiero, Nicola Burdi, Luigi Gozzoli, Mariangela Piano, Nicola Cavasin, Chiara Comelli, Elvis Lafe, Francesco Briganti, Florio F, Nunzio Paolo Nuzzi, Francesco Asteggiano, Marco Pavia, Guglielmo Pero, Emilio Lozupone, Annalisa Sgoifo, Edoardo Boccardi, Dikran Mardighian, Andrea Giorgianni, Giuseppe Iannucci, Guido Trasimeni, Elisa Ciceri, Luca Valvassori, Aldo Paolucci, Alessandro Pedicelli, Guido A Lazzarotti, Simone Vagnarelli, Massimiliano Natrella, Giuseppe Ganci, Paolo Remida, Ivan Gallesio, Piano, M., Lozupone, E., Sgoifo, A., Nuzzi, N. P., Asteggiano, F., Pero, G., Quilici, L., Iannucci, G., Cerini, P., Comelli, C., Peschillo, S., Princiotta, C., Pedicelli, A., Limbucci, N., Ganci, G., Trasimeni, G., Ciceri, E., Farago, G., Giorgianni, A., Denicola, M., Remida, P., Lafe, E., Mardighian, D., Ruggiero, M., Lazzarotti, G. A., Cavasin, N., Castellan, L., Chiumarulo, L., Burdi, N., Paolucci, A., Briganti, F., Natrella, M., Florio, F. P., Pavia, M., Gallesio, I., Lucente, G., Gozzoli, L., Caputo, N., Vagnarelli, S., Boccardi, E., and Valvassori, L.

Subjects
medicine.medical_specialty, medicine.medical_treatment, Neurosurgery, 03 medical and health sciences, Embolization, 0302 clinical medicine, Aneurysm, Modified Rankin Scale, Occlusion, medicine, Humans, Registries, Adverse effect, Retrospective Studies, medicine.diagnostic_test, business.industry, Mortality rate, Endovascular Procedures, medicine.disease, Intracranial aneurysm, Embolization, Therapeutic, Cerebral Angiography, Surgery, Treatment Outcome, Italy, 030220 oncology & carcinogenesis, Angiography, Stents, Neurology (clinical), Therapeutic, business, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

Background The flow-diverter devices (FDDs) safety and effectiveness have been demonstrated by large series and meta-analyses. Due to the high occlusion rates and the acceptable morbidity rates of FDDs, the indications for their use are continuously expanding. We presented our Italian multicentric experience using the second generation of DERIVO® Embolization Device (DED®; Acandis, Pforzheim, Germany) to cure cerebral aneurysms, evaluating both middle and long-term safety and efficacy of this device. Methods Between July 2016 and September 2017 we collected 109 consecutive aneurysms in 108 patients treated using DED® during 109 endovascular procedures in 34 Italian centers (100/109 aneurysms were unruptured, 9/109 were ruptured). The collected data included patient demographics, aneurysm location and characteristics, baseline angiography, adverse event and serious adverse event information, morbidity and mortality rates, and pre- and post-treatment modified Rankin Scale scores. Midterm and long-term clinical, angiographic and cross-sectional CT/MR follow-up were recorded and collected until December 2018. Results In 2/109 cases, DED® placement was classified as technical failures. The overall mortality and morbidity rates were respectively 6.5% and 5.5%. Overall DERIVO® related mortality and morbidity rates were respectively 0% and 4.6% (5 out of 108 patients). Midterm neuroimaging follow-up showed the complete or nearly complete occlusion of the aneurysm in 90% cases, which became 93% at long-term follow-up. Aneurysmal sac shrinking was observed in 65% of assessable aneurysms. Conclusions Our multicentric experience using DED® for endovascular treatment of unruptured and ruptured aneurysms showed a high safety and efficacy profile, substantially equivalent or better compared to the other FDDs.

Published
2021

9. WEB-DL endovascular treatment of wide-neck bifurcation aneurysms: short- and midterm results in a European study

Author

Vojtech Sychra, F. D. Paola, Joachim Klisch, Boris Lubicz, Marco Leonardi, Laurent Pierot, Thomas Liebig, Benjamin Mine, Werner Weber, Nunzio Paolo Nuzzi, E. Calgliari, Markus Holtmannspötter, Jean-Yves Gauvrit, Edoardo Boccardi, István Szikora, Department of Neuroradiology (B.L., B.M.), Erasme University Hospital, Brussels, Belgium., Texas Children's Hospital [Houston, USA], Service de radiologie et imagerie médicale [Rennes] = Radiology [Rennes], CHU Pontchaillou [Rennes], Vision, Action et Gestion d'informations en Santé (VisAGeS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), CentraleSupélec-Télécom Bretagne-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Rennes (ENS Rennes)-Université de Bretagne Sud (UBS)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Télécom Bretagne-Université de Rennes 1 (UR1), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Université de Bretagne Sud (UBS)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Neuroradiology, National Institute of Neurosciences, Budapest, Hungary, Department of Life, Health and Environmental Sciences, L'Aquila University, L'Aquila, Italy, Molecular Medicine, National Heart and Lung Institute, Imperial College London., United Kingdom, Radiodiagnostic and Interventional Radiology Institute, University of Eastern Piedmont, Novara, Italy., Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Università degli studi di Bari Aldo Moro (UNIBA), Division of Interventional Neuroradiology (M.H.), Københavns Universitet, Copenhagen, Denmark, Neuroradiology, Ospedale dell'Angelo, Mestre, Italy, Institute of Diagnostic und Interventional Radiology and Neuroradiology (J.K., V.S., C.S.), Helios Klinikum, Erfurt, Germany, and Departments of Neuroradiology (C.A.T., H.U., S.M.) and Neurology (M.R.), University Hospital Freiburg, Freiburg, Germany, Erasme University Hospital, Department of Diagnostic and Interventional Neuroradiology, Route de Lennik, 808, 1070 Brussels, Belgium, Hôpital Maison Blanche, Centre Hospitalier Universitaire de Reims (CHU Reims), Neuroadiology, Knappschaftskrankenhaus, Recklinghausen, Germany, Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-Télécom Bretagne-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-Télécom Bretagne-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Télécom Bretagne-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Università degli Studi dell'Aquila = University of L'Aquila (UNIVAQ), Imperial College London, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Gauvrit, Jean-Yves, Lubicz B, Klisch J, Gauvrit JY, Szikora I, Leonardi M, Liebig T, Nuzzi NP, Boccardi E, Paola FD, Holtmannspötter M, Weber W, Calgliari E, Sychra V, Mine B, and Pierot L.

Subjects
FLOW-DISRUPTION, medicine.medical_specialty, [SDV]Life Sciences [q-bio], education, MULTICENTER, INTRACRANIAL ANEURYSMS, Aneurysm, Text mining, medicine.artery, Occlusion, medicine, Radiology, Nuclear Medicine and imaging, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], cardiovascular diseases, Endovascular treatment, COILING, [SDV.IB] Life Sciences [q-bio]/Bioengineering, business.industry, Retrospective cohort study, Sciences bio-médicales et agricoles, medicine.disease, 3. Good health, Surgery, [SDV] Life Sciences [q-bio], Anterior communicating artery, Middle cerebral artery, cardiovascular system, TRIAL, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.IB]Life Sciences [q-bio]/Bioengineering, Neurology (clinical), Radiology, Internal carotid artery, FOLLOW-UP, business
Abstract

BACKGROUND AND PURPOSE:Flow disruption with the WEB-DL device has been used safely for the treatment of wide-neck bifurcation aneurysms, but the stability of aneurysm occlusion after this treatment is unknown. This retrospective multicenter European study analyzed short- and midterm data in patients treated with WEB-DL.MATERIALS AND METHODS:Twelve European neurointerventional centers participated in the study. Clinical data and pre- and postoperative short- and midterm images were collected. An experienced interventional neuroradiologist independently analyzed the images. Aneurysm occlusion was classified into 4 grades: complete occlusion, opacification of the proximal recess of the device, neck remnant, and aneurysm remnant.RESULTS:Forty-five patients (34 women and 11 men) 35-74 years of age (mean, 56.3 ± 9.6 years) with 45 aneurysms treated with the WEB device were included. Aneurysm locations were the middle cerebral artery in 26 patients, the posterior circulation in 13 patients, the anterior communicating artery in 5 patients, and the internal carotid artery terminus in 1 patient. Forty-two aneurysms were unruptured. Good clinical outcome (mRS < 2) was observed in 93.3% of patients at the last follow-up. Adequate occlusion (complete occlusion, opacification of the proximal recess, or neck remnant) was observed in 30/37 patients (81.1%) in short-term follow-up (median, 6 months) and in 26/29 patients (89.7%) in midterm follow-up (median, 13 months). Worsening of the aneurysm occlusion was observed in 2/28 patients (7.1%) at midterm follow-up.CONCLUSIONS:The results suggest that the WEB endovascular treatment of wide-neck bifurcation aneurysms offers stable occlusion in a class of aneurysms that are historically unstable. Additionally, our data show that opacification of the WEB recess can be delineated from true neck or aneurysm remnants., JOURNAL ARTICLE, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2014

10. Geometry of the internal carotid artery and recurrent patterns in location, orientation, and rupture status of lateral aneurysms: an image-based computational study

Author

Andrea Remuzzi, Susanna Bacigaluppi, E. Boccardi, Luca Antiga, Alessandro Veneziani, Bogdan Ene-Iordache, Marina Piccinelli, Piccinelli, M, Bacigaluppi, S, Boccardi, E, Ene Iordache, B, Remuzzi, A, Veneziani, A, and Antiga, L

Subjects
Adult, Male, medicine.medical_specialty, Hemodynamics, Intracranial aneurysm, Parent vessel, Rotational angiography, Rupture risk 3D geometry, Geometry, parent vessel, Aneurysm, Ruptured, Curvature, hemodynamics, Aneurysm, Imaging, Three-Dimensional, hemodynamics, intracranial aneurysm, parent vessel, rotational angiography, rupture risk, 3D geometry, medicine.artery, Orientation (geometry), medicine, Image Processing, Computer-Assisted, Secondary Prevention, Humans, cardiovascular diseases, Aged, business.industry, Settore ING-IND/34 - Bioingegneria Industriale, Anatomy, MED/27 - NEUROCHIRURGIA, Middle Aged, medicine.disease, rotational angiography, intracranial aneurysm, Cerebral Angiography, rupture risk 3D geometry, Ostium, cardiovascular system, Surgery, Female, Neurology (clinical), Radiology, Internal carotid artery, business, Image based, Carotid Artery, Internal
Abstract

BACKGROUND: Intracranial aneurysm development and rupture may be associated to the morphology of the parent vessel. OBJECTIVE: To quantitatively characterize the geometry of the internal carotid artery (ICA) in relation to the location and orientation of lateral aneurysms and to identify recurrent patterns associated with their rupture status. METHODS: The geometry of 54 ICAs hosting lateral aneurysms was analyzed by means of computational geometry techniques. The ICA was split into individual bends, and the bend hosting the aneurysm was described in terms of curvature, torsion, length, and radius. Aneurysm position and orientation with respect to the parent vessel and specifically the hosting bend were characterized, as well as angles between the portions of the parent artery immediately upstream of and downstream from the aneurysm and the aneurysm ostium. Differences in geometric parameters with respect to rupture status and their performance as classifiers were evaluated. RESULTS: ICA bends hosting ruptured aneurysms were shorter with a smaller radius, lower maximum curvature, and lower proximal torsion compared with those hosting unruptured lesions. Ruptured aneurysms occurred in more distal portions of the ICA, along the outer wall of the vessel, and closer to the curvature peak within the hosting bend than unruptured ones. The proximal portions of ICAs hosting ruptured aneurysms approached the ostium region at a smaller angle. CONCLUSION: Geometric factors relative to the ICA were associated with the distribution of aneurysms and their rupture status. The present work has potential implications in the quest for hemodynamic factors contributing to the development, progression, and rupture of intracranial aneurysms. Copyright © 2011 by the Congress of Neurological Surgeons.

Published
2011

11. Treatment of Transiently Symptomatic Acute Internal Carotid Artery Occlusion: Learning from the Interventional Field

Author

Simone Beretta, Carlo Ferrarese, Patrizia Santoro, Edoardo Boccardi, G. Pappadà, Beretta, S, Boccardi, E, Santoro, P, Pappadà, G, and Ferrarese, C

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Cerebral arteries, Carotid Stenosi, Severity of Illness Index, Internal medicine, medicine, Humans, Carotid Stenosis, Thrombolytic Therapy, Confusion, Aged, Endarterectomy, Paresis, Endarterectomy, Carotid, Aspirin, business.industry, Platelet Aggregation Inhibitor, Rehabilitation, Anticoagulant, Anticoagulants, Cerebral Arteries, Neurovascular bundle, Cerebral Arterie, Transcranial Doppler, Treatment Outcome, Cerebrovascular Circulation, Carotid artery occlusion, cardiovascular system, Cardiology, Platelet aggregation inhibitor, Surgery, Neurology (clinical), medicine.symptom, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors, Human
Abstract

A 69-year-old man experienced left hemiparesis and confusion of sudden onset, followed by complete spontaneous recovery after about 20 minutes. When carotid ultrasound was performed in the neurovascular unit 12 hours later, an occluded right internal carotid artery was found. Transcranial ultrasound showed normal flow in the right middle and anterior cerebral arteries. How should he be treated?

Published
2009

12. Are sensorimotor strokes lacunar strokes? A case-control study of lacunar and non-lacunar infarcts

Author

Ermelinda Cella, Edoardo Boccardi, Nicoletta Anzalone, M Musicco, G Landi, Landi, G, Anzalone, NICOLETTA EMANUELA, Cella, E, Boccardi, E, and Musicco, M.

Subjects
medicine.medical_specialty, Cerebral infarction, business.industry, Ischemia, Case-control study, medicine.disease, Surgery, nervous system diseases, Lacunar Infarcts, body regions, Psychiatry and Mental health, Internal medicine, medicine, Etiology, Cardiology, Neurology (clinical), Myocardial infarction, cardiovascular diseases, Prospective cohort study, business, Stroke, Research Article
Abstract

To determine whether sensorimotor strokes should be considered as lacunar syndromes 34 consecutive patients with first-ever ischaemic sensorimotor stroke were evaluated and compared with 103 patients with non-lacunar infarcts and another 88 patients with lacunar infarcts. Potential thromboembolic sources were more frequent in patients with non-lacunar infarcts (p = 0.003, versus sensorimotor strokes). Although the overall prevalence of hypodense lesions at CT scan was not significantly different among the three groups, lacunar lesions were found in 47.1% of sensorimotor strokes, compared with 6.8% of non-lacunar infarcts (p less than 0.0001). In a mean follow up period of 28.7 months, the incidence of stroke and myocardial infarction among sensorimotor strokes was similar to that of patients with lacunar infarct, but significantly lower than in non-lacunar infarcts (p less than 0.05). These results demonstrate important differences between sensorimotor and non-lacunar infarcts, but quite similar findings in sensorimotor and lacunar strokes, and thus support the theory that sensorimotor strokes are commonly due to lacunar lesions.

Published
1991

Catalog

Books, media, physical & digital resources
See catalog results