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Background: Acute graft-versus-host disease (GVHD) in the oral cavity is a rare complication of hematopoietic stem cell transplantation (HSCT) and treatment has a varying length of time for wound h...

The report describes a case of mandibular osteosarcoma in a 25-year-old black male patient complaining of increase of volume in mandible with evolution of 4 months. The anamnesis stated a previous history of mucoepidermoid carcinoma in the left retroauricular region treated by parotidectomy 18 years ago. Physical examination revealed the swelling of the left body of the mandible with face asymmetry and an expansive increase of volume in the buccal region of the mandible, extending to vestibule depth, associated with pain on palpation and paresthesia. Panoramic radiograph revealed a poorly defined radiolucent image without sclerotic border, with destruction of the periodontal ligament corresponding to tooth 36. Incisional biopsy was performed, and the histopathologic report was compatible with osteosarcoma. The patient was referred for oncology treatment. Osteosarcomas in the mandible are extremely rare, and this case justifies investigation as the patient had already presented another type of tumor in the proximal region.

Oropharyngeal squamous cell carcinoma (OSCC) accounts for 30% of head and neck neoplasms. Tobacco and alcohol consumption are classic risk factors for this neoplasm. However, human papillomavirus (HPV) is an additional risk. This report describes the case of OSCC in a 60-year-old black man, a smoker and chronic alcoholic, who complained of “pain when swallowing.” A left cervical lymph node measuring 3.0 cm that was fixed and painless was observed at the extraoral examination. Intraoral examination revealed a bleeding hard ulcer with raised edges that was painful to palpation, 6.0 cm in diameter, and located in the left soft palate with 6 months of evolution. An incisional biopsy was performed with well-differentiated OSCC stage III diagnosis and negative immunohistochemistry for p16. The patient was submitted to radiotherapy and neoadjuvant chemotherapy. Classical carcinogenesis induced by tobacco and alcohol appears to be associated with this case rather than HPV infection.