1. Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers.
- Author
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Chan MS, Tam DY, Dai Z, Liu LS, Ho JW, Chan ML, Xu D, Wong MS, Tin C, and Lo PK
- Subjects
- Carbazoles chemistry, DNA metabolism, Endocytosis drug effects, HeLa Cells, Humans, Lipids chemistry, MCF-7 Cells, Mitochondria drug effects, Native Polyacrylamide Gel Electrophoresis, Doxorubicin pharmacology, Drug Carriers chemistry, Mitochondria metabolism, Nanoparticles chemistry, Surface-Active Agents chemistry
- Abstract
The first example of mitochondrial delivery of the anticancer drug doxorubicin (Dox) is presented by lipid-functionalized DNA nanocages (LNCs). Dox localized in mitochondria induces significant cytotoxicity and cellular apoptosis in MCF-7 compared with Dox localized in lysosomes. These results suggest that LNC has the potential to be an outstanding tool in the treatment of specific organelle-related diseases such as cancers., (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2016
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