1. Effect of craniotomy on oxidative stress and its effect on plasma l-carnitine levels.
- Author
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Li, Huan-ting, Zhao, Zhen-huan, Ding, Hai-yan, Wang, Le-xin, and Cao, Yu
- Subjects
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TREATMENT effectiveness , *OXIDATIVE stress , *CRANIOTOMY , *CARNITINE , *THIOBARBITURIC acid test , *SUPEROXIDE dismutase , *THERAPEUTIC use of antioxidants - Abstract
Objective: to investigate the impact of craniotomy on oxidative stress and its effect on levels of plasma l-carnitine (LC). Methods: plasma levels of reactive oxygen species, superoxide dismutase (SOD), glutathion peroxidase (GSH-Px), catalase (CAT), total antioxidative capacity (T-AOC), and thiobarbituric acid reactive substances (TBARS) were measured in 34 patients (26 males and 8 females, mean age 47.7 ± 6.7 years) before and after craniotomy. Plasma levels of LC, acetyl- l-carnitine (ALC), and propionyl- l-carnitine (PLC) were also measured before and after the craniotomy. Results: the plasma concentrations of SOD, GSH-Px, CAT, and T-AOC within the first 4 h after craniotomy were lower than their baseline values ( P < 0.05). There were no statistically significant differences in the mean plasma levels of SOD, GSH-Px, CAT, or T-AOC between the baseline and 24 h post-operative values. The level of TBARS at 4 h after the craniotomy was lower than the pre-operative level ( P < 0.05), but the 24 h post-operative value was similar to the baseline concentration ( P > 0.05). Plasma levels of LC, ALC, and PLC were lower after the craniotomy ( P < 0.05), but these levels returned to the baseline levels 24 h after the operation. Conclusions : craniotomy and the associated procedures for surgery/anesthesia temporarily reduce antioxidant activity and plasma levels of l-carnitine. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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