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Your search keyword '"Chow, W C"' showing total 2 results
Start Over Author "Chow, W C" Topic sulfonamides
2 results on '"Chow, W C"'

1. 5-(Dimethylamino)-N-(4-ethynylphenyl)-1-naphthalenesulfonamide as a novel bifunctional antitumor agent and two-photon induced bio-imaging probe.

Author

Chui CH, Wang Q, Chow WC, Yuen MC, Wong KL, Kwok WM, Cheng GY, Wong RS, Tong SW, Chan KW, Lau FY, Lai PB, Lam KH, Fabbri E, Tao XM, Gambari R, and Wong WY

Subjects
Animals, Antineoplastic Agents chemical synthesis, Apoptosis drug effects, Cell Line, Tumor, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Fluorescent Dyes chemical synthesis, Humans, Mice, Mice, Nude, Molecular Structure, Naphthalenes chemical synthesis, Naphthalenes chemistry, Stereoisomerism, Structure-Activity Relationship, Sulfonamides chemical synthesis, Sulfonamides chemistry, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Fluorescent Dyes chemistry, Fluorescent Dyes pharmacology, Naphthalenes pharmacology, Photons, Sulfonamides pharmacology
Abstract

A novel compound, (5-(dimethylamino)-N-(4-ethynylphenyl)-1-naphthalenesulfonamide), was prepared and characterized; it shows dual functional roles as an effective antitumor and a two-photon induced bio-imaging agent.

Published
2010
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2. Nimesulide-induced hepatotoxicity and fatal hepatic failure.

Author

Tan HH, Ong WM, Lai SH, and Chow WC

Subjects
Aged, Drug-Related Side Effects and Adverse Reactions etiology, Fatal Outcome, Female, Humans, Liver Failure, Acute pathology, Male, Middle Aged, Sorption Detoxification, Cyclooxygenase 2 Inhibitors adverse effects, Drug-Related Side Effects and Adverse Reactions pathology, Liver Failure, Acute chemically induced, Sulfonamides adverse effects
Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) and cyclo-oxygenase-2 (cox-2) inhibitors are structurally heterogeneous drugs that share similar therapeutic actions and adverse effects. Hepatotoxicity, although a relatively rare adverse effect of this class of drugs, can be severe. This has led to the withdrawal of some NSAIDs from the market. Nimesulide is an NSAID, with cox-2 preference, which has been reported to cause death from hepatic failure. However, most reports have been from European countries. Asian reports include that from Israel and India. We report three patients who presented with acute hepatitis after being prescribed nimesulide, one of whom died from fulminant hepatic failure.

Published
2007

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