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Your search keyword '"Lenthe, G. Harry van"' showing total 2 results
Start Over Author "Lenthe, G. Harry van" Topic subchondral bone
2 results on '"Lenthe, G. Harry van"'

1. Correlation between tibial and femoral bone and cartilage changes in end-stage knee osteoarthritis.

Author

Azari, Fahimeh, Colyn, William, Bellemans, Johan, Scheys, Lennart, and Lenthe, G Harry van

Subjects
FEMUR, KNEE osteoarthritis, KNEE, CARTILAGE, CANCELLOUS bone, STRESS concentration
Abstract

Knee osteoarthritis is a whole joint disease highlighting the coupling of cartilage and bone adaptations. However, the structural properties of the subchondral bone plate (SBP) and underlying subchondral trabecular bone (STB) in the femoral compartment have received less attention compared to the tibial side. Furthermore, how the properties in the femoral compartment relate to those in the corresponding tibial site is unknown. Therefore, this study aimed to quantify the structural bone and cartilage morphology in the femoral compartment and investigate its association with those of the tibial plateau. Specifically, tibial plateaus and femoral condyles were retrieved from 28 patients with end-stage knee-osteoarthritis (OA) and varus deformity. The medial condyle of tibial plateaus and the distal part of the medial femoral condyles were micro-CT scanned (20.1 μm/voxel). Cartilage thickness (Cart.Th), SBP, and STB microarchitecture were quantified. Significant (P  < <.001; 0.79 ≤  r  ≤ 0.97) correlations with a relative difference within 10% were found between the medial side of the femoral and tibial compartments. The highest correlations were found for SBP porosity (r  = 0.97, mean absolute difference of 0.50%, and mean relative difference of 9.41%) and Cart.Th (r  = 0.96, mean absolute difference of 0.18 mm, and relative difference of 7.08%). The lowest correlation was found for trabecular thickness (r  = 0.79, mean absolute difference of 21.07 μm, and mean relative difference of 5.17%) and trabecular number (r  = 0.79, mean absolute difference of 0.18 mm−1, and relative difference of 5.02%). These findings suggest that the distal femur is affected by OA in a similar way as the proximal tibia. Given that bone adaptation is a response to local mechanical forces, our results suggest that varus deformity similarly affects the stress distribution of the medial tibial plateau and the medial distal femur. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Microstructural adaptations of the subchondral bone are related to the mechanical axis deviation in end stage varus OA knees

Author

W Colyn, F Azari, J Bellemans, G Harry van Lenthe, L Scheys, Scheys, Lennart/0000-0002-1727-533X, COLYN, William, Azari, F., BELLEMANS, Johan, Lenthe, G. Harry van, and Scheys, L.

Subjects
tibial plateau, ?CT, subchondral bone, Osteoarthritis, varus alignment
Abstract

Recent studies highlighted the crucial contribution of subchondral bone to OA development. Yet, only limited data have been reported on the relation between alteration to cartilage morphology, structural properties of the subchondral bone plate (SBP) and underlying subchondral trabecular bone (STB). Furthermore, the relationship between the morphometry of the cartilage and bone in the tibial plateau and the OA-induced changes in the joint's mechanical axis remains unexplored. Therefore, a visualisation and quantification of cartilage and subchondral bone microstructure in the medial tibial plateau was performed. End stage knee-OA patients with varus alignment and scheduled for total knee arthroplasty (TKA) underwent preoperative full-length radiography to measure the hip-knee-ankle angle (HKA) and the mechanical-axis deviation (MAD). 18 tibial plateaux were mu-CT scanned (20.1 mu m/voxel). Cartilage thickness, SBP, and STB microarchitecture were quantified in 10 volumes of interest (VOIs) in each medial tibial plateau. Significant differences (p < 0.001) were found for cartilage thickness, SBP, and STB microarchitecture parameters among the VOIs. Closer to the mechanical axis, cartilage thickness was consistently smaller, while SBP thickness and STB bone volume fraction (BV/TV) were higher. Moreover, trabeculae were also more superior-inferiorly oriented, i.e. perpendicular to the transverse plane of the tibial plateau. As cartilage and subchondral bone changes reflect responses to local mechanical loading patterns in the joint, the results suggested that region-specific subchondral bone adaptations were related to the degree of varus deformity. More specifically, subchondral sclerosis appeared to be most pronounced closer to the mechanical axis of the knee. This study was part of Limburg Clinical Research Centre supported by Hasselt University, Ziekenhuis Oost-Limburg and Jessa Hospital and was funded in part by KU Leuven Internal Funds, Grant C24/16/027”. Study concept and design: Colyn, Bellemans, Van Lenthe, Scheys; Data acquisition: Colyn, Azari; Statistical analysis: Azari; Data Interpretation: all; Manuscript preparation: Colyn, Azari; Revision of Manuscript drafts: all.

Published
2023

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