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Start Over Author "Wold S" Topic structure-activity relationship
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4. Structure-activity analyzed by pattern recognition: the asymmetric case.

Author

Dunn WJ 3rd and Wold S

Subjects
Antimalarials, Models, Theoretical, Naphthoquinones pharmacology, Pharmaceutical Preparations classification, Plasmodium berghei drug effects, Pattern Recognition, Automated, Structure-Activity Relationship
Abstract

In classification studies in which pattern-recognition methods are used to distinguish active compounds from inactive ones, a type of data structure which we call "asymmetric" can be observed. This type of data structure can be quite common and its occurrence can have a profound effect on the classification analysis outcome. The origin of asymmetric data structure and a strategy or obtaining meaningful classification results when it is observed are discussed and illustrated with an example of active and inactive antimalarial quinones.

Published
1980
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