14 results on '"Belley-Côté, Emilie"'
Search Results
2. Mechanical versus bioprosthetic valves in chronic dialysis: a systematic review and meta-analysis.
- Author
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Kim KS, Belley-Côté EP, Gupta S, Pandey A, Alsagheir A, Makhdoum A, McClure G, Newsome B, Gao SW, Bossard M, Isayama T, Ikuta Y, Walsh M, Garg AX, Guyatt GH, and Whitlock RP
- Subjects
- Hemorrhage etiology, Humans, Renal Dialysis adverse effects, Bioprosthesis adverse effects, Heart Valve Diseases surgery, Heart Valve Prosthesis, Stroke complications
- Abstract
Background: Many patients with end-stage kidney disease (ESKD) have valvular heart disease requiring surgery. The optimal prosthetic valve is not established in this population. We performed a systematic review and meta-analysis to assess outcomes of patients with dialysis-dependent ESKD who received mechanical or bioprosthetic valves., Methods: We searched Cochrane Central, Medline and Embase from inception to January 2020. We performed screening, full-text assessment, risk of bias and data collection, independently and in duplicate. Data were pooled using a random-effects model., Results: We identified 28 observational studies ( n = 9857 patients, including 6680 with mechanical valves and 3717 with bioprosthetic valves) with a median follow-up of 3.45 years. Twenty-two studies were at high risk of bias and 1 was at critical risk of bias from confounding. Certainty in evidence was very low for all outcomes except bleeding. Mechanical valves were associated with reduced mortality at 30 days (relative risk [RR] 0.79, 95% confidence interval [CI] 0.65-0.97, I
2 = 0, absolute effect 27 fewer deaths per 1000) and at 6 or more years (mean 9.7 yr, RR 0.83, 95% CI 0.72-0.96, I = 59%, absolute effect 91 more events per 1000) and stroke (IRR 1.63, 95% CI 1.21-2.20,2 = 79%, absolute effect 145 fewer deaths per 1000), but increased bleeding (incidence rate ratio [IRR] 2.46, 95% CI 1.41-4.27, I2 = 59%, absolute effect 91 more events per 1000) and stroke (IRR 1.63, 95% CI 1.21-2.20, I2 = 0%, absolute effect 25 more events per 1000)., Conclusion: Mechanical valves were associated with reduced mortality, but increased rate of bleeding and stroke. Given very low certainty for evidence of mortality and stroke outcomes, patients and clinicians may choose prosthetic valves based on factors such as bleeding risk and valve longevity., Study Registration: PROSPERO no. CRD42017081863., Competing Interests: Competing interests: Emilie Belley-Côté reports grants Roche, Bayer and Bristol-Myers Squibb-Pfizer, and is chair of the data safety monitoring board of the BEEF-BURGER trial. Matthias Bossard reports consulting fees from Abbott Vascular, Amgen, AstraZeneca, Daichii and Vifor. He also reports speaker fees from Abbott Vascular, Amgen, AstraZeneca, Mundipharma, Bayer, Daichii and Vifor. Richard Whitlock reports grants from Boehringer Ingelheim, Bayer and Abbott; consulting fees from Phasebio, Atricure, Cryolife; and participation on a data safety monitoring board with Phasebio. No other competing interests were declared., (© 2022 CMA Impact Inc. or its licensors.)- Published
- 2022
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3. Concomitant Surgical Left Atrial Appendage Occlusion: a Review.
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Whitlock RP and Belley-Côté EP
- Subjects
- Anticoagulants therapeutic use, Humans, Observational Studies as Topic, Randomized Controlled Trials as Topic, Treatment Outcome, Atrial Appendage surgery, Atrial Fibrillation complications, Atrial Fibrillation surgery, Embolism, Ischemic Stroke, Stroke complications, Stroke prevention & control
- Abstract
Purpose of Review: In this review, we discuss some of the observational studies that examined the impact of left atrial appendage occlusion on stroke, the Left Atrial Appendage Occlusion Study (LAAOS) III research program that provided definitive evidence for the benefit of surgical left atrial appendage occlusion on ischemic stroke, and high priority studies in the field that should be pursued by the surgical community., Recent Findings: Atrial fibrillation is common in patients undergoing cardiac surgery. Oral anticoagulants are effective at preventing strokes related to atrial fibrillation; they have been the standard of care for stroke prevention in patients with atrial fibrillation for decades. Most strokes in patients with atrial fibrillation originate from the left atrial appendage. LAAOS III, a large randomized controlled trial, has recently demonstrated that concomitant left atrial appendage occlusion in patients undergoing cardiac surgery for another indication reduces the risk of stroke or systemic embolism on top of oral anticoagulation. Surgical left atrial appendage occlusion reduces the risk of ischemic stroke and systemic embolism in patients with atrial fibrillation and a CHA
2 DS2 -VASc score ≥ 2 undergoing cardiac surgery for another indication. The role of surgical left atrial appendage occlusion with patients without atrial fibrillation, as a substitute to anticoagulation and as a standalone procedure, remains unclear., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)- Published
- 2022
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4. Oral anticoagulation for patients with atrial fibrillation in the ED: RE-LY AF registry analysis.
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Mendoza PA, McIntyre WF, Belley-Côté EP, Wang J, Parkash R, Atzema CL, Benz AP, Oldgren J, Whitlock RP, and Healey JS
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- Administration, Oral, Anticoagulants therapeutic use, Emergency Service, Hospital, Female, Humans, Male, Registries, Risk Factors, Atrial Fibrillation complications, Atrial Fibrillation diagnosis, Atrial Fibrillation drug therapy, Stroke complications, Stroke prevention & control
- Abstract
Oral anticoagulation (OAC) reduces stroke risk in patients with atrial fibrillation (AF). We sought to determine predictors of OAC initiation in AF patients presenting to the emergency department (ED). Secondary analysis of the RE-LY AF registry which enrolled individuals from 47 countries between 2007 and 2011 who presented to an ED with AF and followed them for 1 year. A total of 4149 patients with AF as their primary diagnosis who were not already taking OAC and had a CHA
2 DS2 -VASc ≥ 1 for men or ≥ 2 for women were included in this analysis. Of these individuals, 26.8% were started on OAC (99.2% vitamin K antagonists) in the ED and 29.8% were using OAC one year later. Factors associated with initiating OAC in the ED included: specialist consultation (relative risk [RR] 1.84, 95%CI 1.44-2.36), rheumatic heart disease (RR 1.60, 95%CI 1.29-1.99), persistence of AF at ED discharge (RR 1.33, 95%CI 1.18-1.50), diabetes mellitus (RR 1.32, 95%CI 1.19-1.47), and hospital admission (RR 1.30, 95%CI 1.14-1.47). Heart failure (RR 0.83, 95%CI 0.74-0.94), antiplatelet agents (RR 0.77, 95%CI 0.69-0.84), and dementia (RR 0.61, 95%CI 0.40-0.94) were inversely associated with OAC initiation. Patients taking OAC when they left the ED were more likely using OAC at 1-year (RR 2.81, 95%CI 2.55-3.09) and had lower rates of death (RR 0.55, 95%CI 0.38-0.79) and stroke (RR 0.59, 95%CI 0.37-0.96). In patients with AF presenting to the ED, prompt initiation of OAC and specialist involvement are associated with a greater use of OAC 1 year later and may result in improved clinical outcomes., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)- Published
- 2022
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5. Costs of surgical ablation of atrial fibrillation in Ontario, Canada from 2006 to 2017.
- Author
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Chow JY, McClure G, Belley-Côté EP, McIntyre WF, Singal RK, and Whitlock RP
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- Humans, Ontario epidemiology, Treatment Outcome, Atrial Fibrillation surgery, Cardiac Surgical Procedures, Catheter Ablation, Stroke epidemiology, Stroke prevention & control
- Abstract
Background: International guidelines currently recommend concomitant surgical ablation of atrial fibrillation (AF) in patients with AF undergoing cardiac surgery. However, a systematic review and meta-analysis of 23 randomized controlled trials (RCTs) showed no significant difference in mortality or stroke in patients who underwent surgical AF ablation compared with those who did not (moderate-quality evidence)., Methods: We estimated the Ontario-wide costs of surgical AF ablation between 2006 and 2017 using data from a systematic review and meta-analysis of RCTs, estimates of case volumes from Ontario Health Insurance Plan fee codes, the ongoing left atrial appendage occlusion study III trial (NCT01561651), institutional costs from large academic centers in Ontario, as well as professional fees based on the Ontario fee schedule. Device costs were obtained from Canadian industry data with expert input., Results: We estimated the average extra cost of surgical AF ablation at $4,287 CAD (95% CI $4,113-4,619) per patient. Procedural costs (equipment costs and physician remuneration) comprise 82.2% of this, while smaller portions relate to the increased need for pacemaker (3.9%) and additional hospital length of stay (13.9%). Approximately 2,391 patients underwent surgical AF ablation between 2006 and 2017, corresponding to an estimated $10.2 million in incremental cost during that time span., Conclusion: Ontario taxpayers spend significant financial resources on surgical ablation of AF, a procedure lacking high-quality evidence demonstrating benefit in reducing mortality or stroke. Further large prospective studies examining clinically important outcomes are needed to justify its routine use in patient care and to guide allocation of healthcare funds., (© 2020 Wiley Periodicals LLC.)
- Published
- 2020
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6. Lower versus Standard INR Targets in Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Author
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Pandey AK, Xu K, Zhang L, Gupta S, Eikelboom J, Cook O, McIntyre WF, Lopes RD, Crowther M, Belley-Côté EP, and Whitlock RP
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- Administration, Oral, Anticoagulants therapeutic use, Asia, Eastern, Hemorrhage, Humans, Myocardial Infarction blood, Myocardial Infarction complications, Odds Ratio, Randomized Controlled Trials as Topic, Reference Standards, Risk, Stroke blood, Thromboembolism blood, Thromboembolism complications, Warfarin therapeutic use, Atrial Fibrillation blood, Cardiology standards, International Normalized Ratio, Stroke prevention & control
- Abstract
Background: Western guidelines recommend an international normalized ratio (INR) range of 2 to 3 when using warfarin for stroke prevention in atrial fibrillation (AF), but lower INR ranges are frequently used in East Asia. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) in AF patients comparing the effect of lower versus standard INR targets on thromboembolism, major bleeding, and mortality., Methods: We searched Western databases including Cochrane CENTRAL, Medline, and Embase as well as Chinese databases including SinoMed, CNKI, and Wanfang Data. We pooled risk ratios (RRs) using random-effects model. We grouped INR targets in two ways: (1) any study-specific lower versus standard targets and (2) INR ranges of approximately 1.5 to 2 versus 2 to 3., Results: Seventy-nine RCTs ( n = 12,928) met eligibility criteria: 74 ( n = 11,322) from East Asia and 5 ( n = 1,606) from Western countries. Compared with standard targets, lower INR ranges were associated with higher rates of thromboembolism (76 RCTs, n = 12,577: 7.1% vs. 4.4%, RR 1.50, 95% confidence interval [CI] 1.29-1.74, I
2 = 0%), lower rates of major bleeding (61 RCTs, n = 10,815: 2.2% vs. 4.4%, RR 0.54, 95% CI 0.44-0.67, I2 = 0%), and similar mortality (32 RCTs, n = 7,327: 4.8% vs. 5.2%, RR 1.00, 95% CI 0.85-1.19, I2 = 0%). Results were similar when comparing target ranges of approximately 1.5 to 2 versus 2 to 3., Conclusion: Moderate quality evidence suggests lower INR targets reduce bleeding but increase thromboembolism in AF. The data are dominated by East-Asian studies, limiting generalizability to Western populations. Until higher quality data demonstrate otherwise, an INR range of 2 to 3 should remain standard for thromboembolic prophylaxis in AF., Competing Interests: M.C. reports sitting on a DSMB for Bayer, grants and personal fees from BMS Canada, grants and personal fees from Servier Canada, grants and personal fees from Diagnostica Stago, personal fees from Pfizer, personal fees from CSL Behring, personal fees from Diagnostica Stago, and individual stock ownership in Alnylam, outside the submitted work. R.D.L. reports personal fees from Bayer, personal fees from Boehringer Ingleheim, grants and personal fees from Bristol-Myers Squibb, personal fees from Daiichi Sankyo, grants and personal fees from Glaxo Smith Kline, grants and personal fees from Medtronic, personal fees from Merck, grants and personal fees from Pfizer, personal fees from Portola, grants and personal fees from Sanofi, outside the submitted work. R.P.W. reports grants from Bayer, grants from Boehringer Ingelheim, outside the submitted work. W.F.M. reports personal fees from Servier, outside the submitted work. J.E. reports grants and personal fees from Astra-Zeneca, grants and personal fees from Bayer, grants and personal fees from Boehringer-Ingelheim, grants and personal fees from Bristol-Myer-Squibb, grants and personal fees from Glaxo-Smith-Kline, grants and personal fees from Pfizer, grants and personal fees from Janssen, personal fees from Daiichi-Sankyo, personal fees from Eli-Lilly, grants and personal fees from Sanofi-Aventis, personal fees from Servier, outside the submitted work. All the other authors report no conflict of interest., (Georg Thieme Verlag KG Stuttgart · New York.)- Published
- 2020
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7. Left Atrial Appendage Occlusion: A Narrative Review.
- Author
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Alsagheir A, Koziarz A, Belley-Côté EP, and Whitlock RP
- Subjects
- Atrial Fibrillation complications, Humans, Stroke etiology, Atrial Appendage surgery, Atrial Fibrillation surgery, Cardiac Surgical Procedures methods, Septal Occluder Device, Stroke prevention & control
- Abstract
Left atrial appendage occlusion (LAAO) is a proposed alternative to oral anticoagulation in reducing stroke in patients with atrial fibrillation. It is suggested that LAAO is most suitable in patients at increased risk of stroke or bleeding or with contraindication to pharmacologic intervention. Despite the increase in evidence evaluating LAAO, the relative safety and efficacy of the procedure remains uncertain. Presently, several ongoing randomized trials are comparing various devices to each other and to pharmacologic anticoagulation. The objectives of this narrative review were to present the evidence on percutaneous and surgical LAAO devices, review current guidelines, and summarize landmark trials., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2019
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8. Thoracoscopic Left Atrial Appendage Occlusion for Stroke Prevention Compared With Long-Term Warfarin Therapy in Patients With Nonvalvular Atrial Fibrillation.
- Author
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Gao SW, Belley-Côté EP, Um KJ, and Whitlock RP
- Subjects
- Anticoagulants, Humans, Warfarin, Atrial Appendage, Atrial Fibrillation, Stroke
- Published
- 2019
- Full Text
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9. Underpowered observational studies create confusion regarding clinical impact of surgical interventions.
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Gupta S, Belley-Côté EP, and Whitlock RP
- Subjects
- Anticoagulants, Case-Control Studies, Humans, Retrospective Studies, Atrial Appendage, Atrial Fibrillation, Stroke
- Published
- 2019
- Full Text
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10. The limitations of observational data in assessing surgical left atrial appendage ligation.
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Gupta S, Belley-Côté EP, and Whitlock RP
- Subjects
- Coronary Artery Bypass, Humans, Incidence, Ligation, Atrial Appendage, Stroke
- Published
- 2018
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11. Limitations of Administrative Data for Examining Secondary Atrial Fibrillation.
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Um KJ, Belley-Côté EP, Healey JS, and McIntyre WF
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- Anticoagulants, Humans, Acute Coronary Syndrome, Atrial Fibrillation, Brain Ischemia, Lung Diseases, Sepsis, Stroke
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- 2018
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12. A Systematic Review of Ongoing Registered Research Studies on Post-Operative Atrial Fibrillation after Cardiac Surgery.
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Quan, Ivy, Belley-Côté, Emilie P., Spence, Jessica, Wang, Austine, Sidhom, Karen, Wang, Michael Ke, Conen, David, Sun, Bryan, Shankar, Aadithya Udaya, Whitlock, Richard P., Devereaux, P. J., Healey, Jeff S., and McIntyre, William F.
- Subjects
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CLINICAL trial registries , *CARDIAC surgery , *ATRIAL fibrillation , *ORAL surgery , *DISEASE relapse - Abstract
Background/Objectives: New-onset atrial fibrillation (AF) after cardiac surgery is associated with patient-important outcomes. Uncertainty persists regarding its prevention, detection, and management. This review seeks to identify, compile, and describe ongoing registered research studies involving patients with or at risk for post-operative AF (POAF) after cardiac surgery. Methods: We searched clinical trial registries in January 2023 for studies focusing on POAF prediction, prevention, detection, or management. We extracted data from each record and performed descriptive analyses. Results: In total, 121 studies met the eligibility criteria, including 82 randomized trials. Prevention studies are the most common (n = 77, 63.6%), followed by prediction (n = 21, 17.4%), management (n = 16, 13.2%), and detection studies (n = 7, 5.8%). POAF after cardiac surgery is an area of active research. Conclusions: There are many ongoing randomized prevention studies. However, two major clinical gaps persist; future randomized trials should compare rate and rhythm control in patients who develop POAF, and long-term follow-up studies should investigate strategies to monitor for AF recurrence in patients with POAF. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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13. Incidence and recurrence of new-onset atrial fibrillation detected during hospitalization for non-cardiac surgery: a systematic review and meta-analysis
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McIntyre, William F., Vadakken, Maria E., Rai, Anand S., Thach, Terry, Syed, Wajahat, Um, Kevin J., Ibrahim, Omar, Dalmia, Shreyash, Bhatnagar, Akash, Mendoza, Pablo A., Benz, Alexander P., Bangdiwala, Shrikant I., Spence, Jessica, McClure, Graham R., Huynh, Jessica T., Zhang, Tianyi, Inami, Toru, Conen, David, Devereaux, P. J., Whitlock, Richard P., Healey, Jeff S., and Belley-Côté, Emilie P.
- Published
- 2021
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14. Anatomical and electrical remodeling with incomplete left atrial appendage ligation: Results from the LAALA‐AF registry.
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Alsagheir, Ali, Belley‐Côté, Emilie P., and Whitlock, Richard P.
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ANTICOAGULANTS , *LEFT heart atrium , *ATRIAL fibrillation , *CEREBRAL hemorrhage , *CARDIAC surgery , *STROKE , *WARFARIN , *ANATOMY , *PHYSIOLOGY - Published
- 2018
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