1. Novel protein vaccine candidates against Group B streptococcal infection identified using alkaline phosphatase fusions.
- Author
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Hughes MJ, Wilson R, Moore JC, Lane JD, Dobson RJ, Muckett P, Younes Z, Pribul P, Topping A, Feldman RG, and Santangelo JD
- Subjects
- Alkaline Phosphatase genetics, Animals, Antibodies, Bacterial, Bacterial Vaccines pharmacology, Cloning, Molecular, Escherichia coli, Immunoglobulin G, Rabbits, Rats, Recombinant Fusion Proteins genetics, Recombinant Fusion Proteins immunology, Streptococcal Infections immunology, Alkaline Phosphatase immunology, Bacterial Vaccines genetics, Streptococcal Infections prevention & control, Streptococcus agalactiae
- Abstract
Using an alkaline phosphatase-based genetic screening method, we identified a number of proteins that are potentially located on the outer surface of Group B streptococcus (Streptococcus agalactiae). In an enzyme-linked immunosorbent assay, antisera raised against two of the proteins, the streptococcal yutD homologue and a subunit of an ABC transporter, recognised clinically important serotypes of Group B streptococcus. In a neonatal rat model, purified IgG from the sera conferred significant levels of protection against a lethal challenge infection. The proteins identified show potential as protein subunit candidates for vaccines against Group B streptococcal disease in neonates.
- Published
- 2003
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