1. Association of cagA+ Helicobacter pylori strains with high urease activity and dyspepsia in Mexican adults.
- Author
-
Moreno-Ochoa MF, Valencia ME, Morales-Figueroa GG, and Moya-Camarena SY
- Subjects
- Adult, Aged, Breath Tests, Educational Status, Gastric Juice enzymology, Gastric Juice microbiology, Humans, Income, Mexico, Middle Aged, Socioeconomic Factors, Surveys and Questionnaires, Urea metabolism, Antigens, Bacterial genetics, Bacterial Proteins genetics, Dyspepsia microbiology, Helicobacter Infections enzymology, Helicobacter Infections microbiology, Helicobacter pylori genetics, Stomach enzymology, Stomach microbiology, Urease metabolism
- Abstract
Introduction and Aims: Helicobacter pylori (H. pylori) is associated with a higher risk of peptic ulcer and gastric cancer. The sole presence of the bacterium is not a determinant of clinical outcome, but rather the interaction of strain type and host factors determines the risk of disease. Our aim was to study the association between bacterial load, strain type, and gastric symptoms in H. pylori-positive subjects., Materials and Methods: In a community survey, a diagnostic
13 C-urea breath test for H. pylori was performed on 302 volunteers that were not taking antibiotics, antacids, or proton pump inhibitors one month prior to the test. The breath test produced 25 H. pylori-positive subjects, between 25-74 years of age, who then took a gastric symptoms survey and were tested for the presence of the cagA genotype in gastric juice, using the Entero-test®. Bacterial load was determined as a measure of urease activity, utilizing the delta over baseline value, obtained in the13 C-urea breath test., Results: A total of 48% of the H. pylori-positive subjects were cagA+. A positive association was found between cagA status and high gastric urease activity (P<.0001) and the latter was significantly associated with the presence of symptoms (P<.0001)., Conclusion: Gastric urease activity was strongly associated with dyspeptic symptoms and cagA+ H. pylori. Elevated13 C-delta over baseline values could be used as indicators of a higher risk for gastric disease., (Copyright © 2020 Asociación Mexicana de Gastroenterología. Publicado por Masson Doyma México S.A. All rights reserved.)- Published
- 2020
- Full Text
- View/download PDF