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For the first time, a method for isolation and purification of Nox isoforms (Nox1+Nox2), as well as of O2–-producing stable associates of Nox and lipoprotein-containing NADPH isoforms (NCL associates), from the membranes of cells and intracellular formations of the spinal cord (SC) and bone marrow (BM) of albino rats was developed, and the respective estimates were obtained. The effects of treatment with a phytopreparation of Stevia (Stevia rebaudiana Bertoni) leaves in this pathology were studied in a model of fructose-induced type II diabetes (FID) in rats with spinal cord injury (SCI). Due to its antioxidant activity, Stevia exhibited a clear membrane-stabilizing effect in rats with FID and SC hemisection. In such experimental animals, the qualitative and quantitative indices for Nox isoforms and NCL associates from the SC and BM membranes showed clear trends toward normalization. [ABSTRACT FROM AUTHOR]

Stevia rebaudianaBertoni has been imported to the RA and Artsakh, and passed through the phase of production test. Complex researches have been carried out concerning to biological, biochemical and physiological influence of Stevia rebaudianaBertoni and food safety. As a result, it was provided, at least, 2,0-2,5 t/ha harvest in dry leaves soil culture and 4,5-5,0 t/ha harvest of preferable quality with the use of hydroponic phytotechnology. Stevia rebaudianaBertoni was proposed by NAS Institute of HydroponicsProblems of RA and was registered in RA National institute of standards, as a new technical cultured plant in Armenia [15]. [ABSTRACT FROM AUTHOR]