1. Electrochemiluminescent enantioselective detection with chiral-imprinted mesoporous metal surfaces
- Author
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Sopon Butcha, Jing Yu, Zikkawas Pasom, Bertrand Goudeau, Chularat Wattanakit, Neso Sojic, Alexander Kuhn, Vidyasirimedhi Institute of Science and Technology [Thaïlande] (VISTEC), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ERC Advanced ELECTRA - Electrochemically induced asymmetryNuméro CORDIS : 741251, National Research Council of Thailand (N41B650204), CNRS IRP project Chira-Chem, Mid-Career Research Grant 2020 from NRTC (NRCT5-RSA63025-03), NSRF via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation (B05F640207), and European Project: 741251,ERC Advanced ELECTRA
- Subjects
Phenylalanine ,Luminescent Measurements ,Materials Chemistry ,Metals and Alloys ,Ceramics and Composites ,[CHIM]Chemical Sciences ,Stereoisomerism ,Electrochemical Techniques ,General Chemistry ,Catalysis ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Abstract
International audience; Chiral-imprinted mesoporous Pt-Ir alloy surfaces were combined in a synergetic way with electrochemiluminescence (ECL) to detect the two enantiomers of phenylalanine (PA) as a model compound, acting simultaneously as a chiral target and as a co-reactant to generate significant differences in ECL signals. The chiral features of the metal surfaces are converted into an enantioselective electrogeneration of the excited state of the [Ru(bpy)3]2+ dye, which in fine produces the differentiating light emission with up to 20-fold differences in intensity for the two enantiomers. These findings open up the possibility of developing new ECL-based bioassays and microscopy of chiral environments.
- Published
- 2022