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Your search keyword '"Sun, Wenzhong"' showing total 4 results
Start Over Author "Sun, Wenzhong" Topic starch
4 results on '"Sun, Wenzhong"'

1. Calcium ion-exchange cross-linked porous starch microparticles with improved hemostatic properties.

Author

Zhu J, Sun Y, Sun W, Meng Z, Shi Q, Zhu X, Gan H, Gu R, Wu Z, and Dou G

Subjects
Animals, Blood Coagulation drug effects, Chemical Phenomena, Hemostasis drug effects, Kinetics, Mice, Platelet Adhesiveness drug effects, Porosity, Spectroscopy, Fourier Transform Infrared, Starch ultrastructure, X-Ray Diffraction, Calcium chemistry, Hemostatics chemistry, Hemostatics pharmacology, Ion Exchange, Ions chemistry, Starch chemistry
Abstract

Starch hemostatic agents have been clinically used in surgical hemostasis in recent years. Calcium ion (Ca 2+ )-exchange cross-linked porous starch microparticles (Ca 2+ CPSMs) were prepared as a new hemostatic agent to enhance the hemostatic efficacy. A series of Ca 2+ CPSMs with varying Ca 2+ contents were prepared and characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), scanning electron microscope (SEM), and ion content analysis. The XPS and FT-IR results indicated that the surface of Ca 2+ CPSMs was modified by Ca 2+ , which might form coordination bonds with oxygen atoms of starch molecules. Ca 2+ CPSMs revealed a porous surface structure and a lower crystallinity degree according to SEM and XRD, which facilitated the phosphate buffer saline (PBS) uptake rate and enzymatic degradation in vitro. The fast release of Ca 2+ from Ca 2+ CPSMs accelerated the whole blood clotting rate, shortened the activated partial thromboplastin time, and promoted platelet adhesion. The physical hemostatic mechanism benefited from the rapid PBS uptake capacity and porous surface structure of Ca 2+ CPSMs, in addition to the chemical activation of coagulation process by Ca 2+ , thus achieving a significant hemorrhage control in the mouse tail amputation model., (Copyright © 2019. Published by Elsevier B.V.)

Published
2019
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2. Preparation and characterization of a new type of porous starch microspheres (PSM) and effect of physicochemical properties on water uptake rate.

Author

Zhu J, Sun W, Meng Z, Zhu X, Gan H, Gu R, Wu Z, and Dou G

Subjects
Cross-Linking Reagents chemistry, Epichlorohydrin chemistry, Porosity, Microspheres, Starch chemistry, Water chemistry
Abstract

Porous starch (PS) is a multifunctional biomaterial and has been widely applied in both pharmaceutical and food industry. This study was carried out to develop a new type of porous starch microspheres (PSM) through the dual-modification of the alcohol-alkaline treatment and inverse crosslinking-emulsion method, which could rapidly uptake water. The chemical and physical characteristics of the PSMs were determined by FTIR, SEM, XRD, DSC, ESD (equilibrium swelling ratio) and WS (water solubility). The results showed that PSMs could reach its saturated water uptake volume (about 1 mL/100 mg) in 60 s. The PSMs also revealed rough surface with observable pores and lower crystallinity degree after the dual-modification according to SEM and XRD. The use of epichlorohydrin (ECH) as a crosslinking agent could introduce crosslinks between starch molecular chains, which was determined by ESD, WS and the thermal properties. These results indicated that the dual-modification could be successfully used for preparation of rapid water uptake PSMs with enhanced structure stability., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2018
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3. Calcium ion-exchange cross-linked porous starch microparticles with improved hemostatic properties

Author

Ruolan Gu, Yunbo Sun, Xiaoxia Zhu, Zhuona Wu, Sun Wenzhong, Hui Gan, Zhiyun Meng, Guifang Dou, Jianjun Zhu, and Qiaoli Shi

Subjects
Chemical Phenomena, Scanning electron microscope, Starch, chemistry.chemical_element, Infrared spectroscopy, 02 engineering and technology, Calcium, Biochemistry, Hemostatics, 03 medical and health sciences, Crystallinity, chemistry.chemical_compound, Mice, Platelet Adhesiveness, X-ray photoelectron spectroscopy, X-Ray Diffraction, Structural Biology, Spectroscopy, Fourier Transform Infrared, Molecule, Animals, Molecular Biology, Blood Coagulation, 030304 developmental biology, Ions, 0303 health sciences, Hemostatic Agent, Hemostasis, General Medicine, 021001 nanoscience & nanotechnology, Ion Exchange, Kinetics, chemistry, 0210 nano-technology, Porosity, Nuclear chemistry
Abstract

Starch hemostatic agents have been clinically used in surgical hemostasis in recent years. Calcium ion (Ca2+)-exchange cross-linked porous starch microparticles (Ca2+CPSMs) were prepared as a new hemostatic agent to enhance the hemostatic efficacy. A series of Ca2+CPSMs with varying Ca2+ contents were prepared and characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), scanning electron microscope (SEM), and ion content analysis. The XPS and FT-IR results indicated that the surface of Ca2+CPSMs was modified by Ca2+, which might form coordination bonds with oxygen atoms of starch molecules. Ca2+CPSMs revealed a porous surface structure and a lower crystallinity degree according to SEM and XRD, which facilitated the phosphate buffer saline (PBS) uptake rate and enzymatic degradation in vitro. The fast release of Ca2+ from Ca2+CPSMs accelerated the whole blood clotting rate, shortened the activated partial thromboplastin time, and promoted platelet adhesion. The physical hemostatic mechanism benefited from the rapid PBS uptake capacity and porous surface structure of Ca2+CPSMs, in addition to the chemical activation of coagulation process by Ca2+, thus achieving a significant hemorrhage control in the mouse tail amputation model.

Published
2019

4. Preparation and characterization of a new type of porous starch microspheres (PSM) and effect of physicochemical properties on water uptake rate

Author

Guifang Dou, Sun Wenzhong, Zhiyun Meng, Ruolan Gu, Xiaoxia Zhu, Hui Gan, Zhuona Wu, and Jianjun Zhu

Subjects
Materials science, Starch, 02 engineering and technology, Biochemistry, chemistry.chemical_compound, Crystallinity, 0404 agricultural biotechnology, Structural Biology, Epichlorohydrin, Fourier transform infrared spectroscopy, Molecular Biology, Aqueous solution, technology, industry, and agriculture, Biomaterial, Water, 04 agricultural and veterinary sciences, General Medicine, 021001 nanoscience & nanotechnology, 040401 food science, Microspheres, Characterization (materials science), Cross-Linking Reagents, chemistry, Volume (thermodynamics), Chemical engineering, 0210 nano-technology, Porosity
Abstract

Porous starch (PS) is a multifunctional biomaterial and has been widely applied in both pharmaceutical and food industry. This study was carried out to develop a new type of porous starch microspheres (PSM) through the dual-modification of the alcohol-alkaline treatment and inverse crosslinking-emulsion method, which could rapidly uptake water. The chemical and physical characteristics of the PSMs were determined by FTIR, SEM, XRD, DSC, ESD (equilibrium swelling ratio) and WS (water solubility). The results showed that PSMs could reach its saturated water uptake volume (about 1 mL/100 mg) in 60 s. The PSMs also revealed rough surface with observable pores and lower crystallinity degree after the dual-modification according to SEM and XRD. The use of epichlorohydrin (ECH) as a crosslinking agent could introduce crosslinks between starch molecular chains, which was determined by ESD, WS and the thermal properties. These results indicated that the dual-modification could be successfully used for preparation of rapid water uptake PSMs with enhanced structure stability.

Published
2018

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