1. Locally advanced tongue squamous cell carcinoma in epidermolysis simplex bullosa patient: a therapeutic conundrum.
- Author
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Al Shareef W, Sayed S, Kamel S, Alkaf H, Bahaj A, Amin R, and Al Herabi A
- Subjects
- Adult, Disease Progression, Epidermolysis Bullosa Simplex complications, Epidermolysis Bullosa Simplex pathology, Fatal Outcome, Humans, Male, Neoplasm Staging, Radiodermatitis etiology, Radiotherapy, Intensity-Modulated adverse effects, Squamous Cell Carcinoma of Head and Neck complications, Squamous Cell Carcinoma of Head and Neck pathology, Squamous Cell Carcinoma of Head and Neck radiotherapy, Stomatitis etiology, Tongue Neoplasms complications, Tongue Neoplasms pathology, Tongue Neoplasms radiotherapy, Epidermolysis Bullosa Simplex diagnosis, Squamous Cell Carcinoma of Head and Neck diagnostic imaging, Tongue Neoplasms diagnostic imaging
- Abstract
Epidermolysis bullosa simplex (EBS) is a debilitating condition affecting the skin and mucous membranes that is characterised by frequent ulceration and blistering on trivial trauma. In EBS, oral cavity mucosal injuries lead to a high propensity for developing squamous cell carcinomas. Locally advanced tongue carcinoma arising in this background presents a challenging therapeutic conundrum. To our knowledge, this is the first case of aggressive locally advanced tongue carcinoma that has developed sporadically in a patient with EBS and no family history. Routine screening of oral mucosal lesions will lead to early detection and timely management of this debilitating condition.
- Published
- 2021
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