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OBJECTIVE: The aim of this study was to describe the clinico-histological pattern of sinonasal space occupying lesions in patients admitted in Ear Nose and Throat (ENT) Department of tertiary care Hospital. STUDY DESIGN: A retrospective descriptive study. PLACE AND DURATION: Pathology Department Bannu Medical College and ENT Department Khalifa Gul Nawaz Teaching Hospital Bannu KPK, from 1st January 2011 to 31st December 2016. METHODOLOGY: In this study a total of 68 patients with sinonasal lesions were analyzed. All patients of any age and sex were studied. Patients clinical record was collected from ENT ward register of the Hospital and biopsy histopathological reports were collected from register of Pathology Deptt of Bannu Medical College. The parameters age, sex, clinical findings and histological pattern of different sinonasal lesions were assessed for frequencies with percentages and mean with standard deviation in Statistical Package for Social Sciences (SPSS) version 20. RESULTS: The mean age was 31.55±13.5 years with age range of 15 to 65 years. Male patients were 67.64% and female 32.35% and male to female ratio was 2.09:1. Nasal obstruction was present in 57 (83.82%) patients followed by nasal discharge in 42 (61.76%) and epistaxis in 13 (19.11%). The common non neoplastic lesion was inflammatory nasal polyp 34 (50.0%). In benign neoplastic lesions inverted papilloma was the common lesion 9 (13.23%) and squamous cell carcinoma was the common malignant lesion in 5 (7.35%) cases. CONCLUSION: This study show almost the same clinico-histological pattern of sinonasal mass lesions as in other studies. Inflammatory nasal polyp was the commonest non neoplastic inflammatory lesion, whereas inverted papilloma was the commonest benign neoplastic lesion and squamous cell carcinoma was the commonest malignant lesion in this study. [ABSTRACT FROM AUTHOR]

Purpose: The study aimed to evaluate diffusion kurtosis imaging (DKI) in the differentiation between benign and malignant sinonasal lesions, and to compare the diagnostic performance of DKI with diffusion weighted imaging (DWI).Materials and Methods: Eight-one patients with solid sinonasal lesions confirmed by surgery and pathology (46 malignant and 35 benign) underwent conventional MRI, DWI, and DKI. DKI was performed employing a 13 extended b-value ranging from 0 to 2500 s/mm2 . Apparent diffusion coefficient (ADC) from DWI, kurtosis (K), and diffusion coefficient (D) from DKI were measured and compared between two groups.Results: ADC and D values were significantly lower in the malignant sinonasal lesions than in the benign sinonasal lesions (1.11 ± 0.41 versus 1.58 ± 0.50 × 10-3 mm2 /s and 1.45 ± 0.36 versus 2.03 ± 0.49 × 10-3 mm2 /s, respectively, both P < 0001). K value was significantly higher in the malignant lesions than in the benign lesions (0.91 ± 0.23 versus 0.57 ± 0.24, P < 0001). The receiver operating characteristic curve analyses yielded a cutoff ADC value of 1.27 × 10-3 mm2 /s for differentiating between benign and malignant lesions, with a sensitivity of 69.6%, a specificity of 77.1% and an accuracy of 74.0%; a cutoff D value of 1.75 × 10-3 mm2 /s, with a sensitivity of 82.6%, a specificity of 77.1% and an accuracy of 80.2%; a cutoff K value of 0.63 with a sensitivity of 95.7%, a specificity of 77.1% and an accuracy of 87.7%. The area under the curve of K value was significantly larger than that of ADC value (0.875 versus 0.762; P < 0.05).Conclusion: K value of DKI demonstrates significantly higher accuracy compared with ADC value for the differentiation between benign and malignant sinonasal lesions. DKI may be a noninvasive method to evaluate the sinonasal lesions.Level Of Evidence: 1 J. MAGN. RESON. IMAGING 2017;45:1446-1454. [ABSTRACT FROM AUTHOR]