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Your search keyword '"Sphingolipids -- Physiological aspects"' showing total 17 results
Start Over Descriptor "Sphingolipids -- Physiological aspects" Topic sphingosine -- physiological aspects
17 results on '"Sphingolipids -- Physiological aspects"'

1. Investigators from University of Turin Have Reported New Data on Insulin Resistance (Altered Hepatic Sphingolipid Metabolism In Insulin Resistant Mice: Role of Advanced Glycation Endproducts)

Subjects
Physiological aspects, Physical fitness -- Physiological aspects, Sphingosine -- Physiological aspects, Insulin resistance -- Physiological aspects, Medical research -- Physiological aspects, Membrane lipids -- Physiological aspects, Sphingolipids -- Physiological aspects, Medicine, Experimental -- Physiological aspects
Abstract

2021 JUL 3 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Endocrine System Diseases and Conditions - Insulin Resistance [...]

Published
2021

2. New Molecular Science Data Have Been Reported by Researchers at Henan University (Fumonisin B1 as a Tool to Explore Sphingolipid Roles in Arabidopsis Primary Root Development)

Subjects
Physiological aspects, Arabidopsis thaliana -- Physiological aspects, Sphingosine -- Physiological aspects, Sphingolipids -- Physiological aspects
Abstract

2022 DEC 2 (NewsRx) -- By a News Reporter-Staff News Editor at Science Letter -- Fresh data on molecular science are presented in a new report. According to news originating [...]

Published
2022

3. New Acute Myeloid Leukemia Research from Abdullah Gul University Described (Resveratrol Targets Sphingolipid Metabolism to Induce Growth Inhibition in FLT3 ITD Acute Myeloid Leukemia)

Subjects
Physiological aspects, Research, Physical fitness -- Physiological aspects, Sphingosine -- Physiological aspects, Resveratrol -- Physiological aspects, Cancer research -- Physiological aspects, Membrane lipids -- Physiological aspects, Sphingolipids -- Physiological aspects, Acute myelocytic leukemia -- Research -- Physiological aspects, Plant lipids, Fate, Serine, Myeloid leukemia, Universities and colleges, Lipids, Obesity, Phosphates, Leukemia research, Apoptosis, Editors
Abstract

2020 FEB 15 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on acute myeloid leukemia is now available. According to [...]

Published
2020

4. Investigators at University of Wurzburg Release New Data on Measles Virus (Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro)

Subjects
Physiological aspects, Measles -- Physiological aspects, Lymphocytes -- Physiological aspects, Physical fitness -- Physiological aspects, Antiviral agents -- Physiological aspects, Sphingosine -- Physiological aspects, Sphingolipids -- Physiological aspects, Virus diseases, Obesity, Membrane lipids, Plant lipids, Editors, Lipids
Abstract

2019 OCT 19 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on measles virus have been published. According to news [...]

Published
2019

5. Researchers' Work from University of Tubingen Focuses on Thrombosis (Ceramidase critically affects GPVI-dependent platelet activation and thrombus formation)

Subjects
Physiological aspects, Research, Physical fitness -- Physiological aspects, Thrombosis -- Research -- Physiological aspects, Sphingosine -- Physiological aspects, Membrane lipids -- Physiological aspects, Sphingolipids -- Physiological aspects
Abstract

2018 MAR 31 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on Cardiovascular Diseases and Conditions - Thrombosis have been presented. [...]

Published
2018

6. Ceramide conversion to sphingosine-1-phosphate is essential for survival in C3H10T1/2 cells. (Biochemical and Molecular Action of Nutrients)

Author

Castillo, S. Sianna and Teegarden, Dorothy

Subjects
Sphingosine -- Physiological aspects, Sphingolipids -- Physiological aspects, Lipids -- Physiological aspects, Cells -- Physiological aspects, Phosphates -- Physiological aspects, Food/cooking/nutrition
Abstract

Ceramide and sphingosine-1-phosphate (S1P) are important dietary lipids involved in cell growth, differentiation, apoptosis and cell survival. Treatment of C3H10T1/2 murine fibroblast cells (10T1/2) with ceramide did not induce apoptosis, a commonly observed effect of ceramide treatment. To determine whether the metabolism of ceramide played a role in this resistance to apoptosis, inhibitors of ceramidase and sphingosine kinase, two important enzymes in sphingolipid metabolism, were used. Treatment of 10T1/2 cells both without or with ceramide plus N-oleoyl-ethanolamine (NOE) and (1S,2R)-D-erythro-s-(N-myristoylamino)-1-phenol-1-propanol (MAPP), two ceramidase inhibitors, resulted in fourfold and eightfold increases, respectively, in apoptosis. Cells treated without or with ceramide plus N,N-dimethylsphingosine (DMS), a potent sphingosine kinase inhibitor, resulted in fourfold and sixfold increases, respectively, in apoptosis. In all treatments the induction of apoptosis was prevented by the addition of S1P. With the addition of S1P with NOE and MAPP as well as with ceramide, treatments reduced the apoptotic response by 30 and 35%, respectively; whereas the addition of S1P with the DMS only and ceramide with DMS treatments reduced the apoptotic response by 60 and 70%, respectively. Studies using labeled ceramide demonstrated ceramide was metabolized to S1P. In addition, a 14-fold increase in apoptosis occurred in cells treated with a nonhydrolyzable analog of ceramide, ceramine, compared with vehicle control. Because inhibiting the conversion of ceramide to S1P resulted in apoptosis, the lack of an apoptotic response to ceramide alone for C3H10T1/2 cells is attributable to the conversion of this pro-apoptotic sphingolipid to the anti-apoptotic metabolite S1P, which is essential for cell survival. J. Nutr. 131: 2826-2830, 2001. KEY WORDS: * C3H10T1/2 cells * ceramide * sphingosine-1-phosphate * apoptosis

Published
2001

7. Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase

Author

Usta, Julnar, Bawab, Samer El, Roddy, Patrick, Szulc, Zdzislaw M., Hannan, A. Yusuf, and Bielawska, Alicja

Subjects
Biochemistry -- Research, Sphingolipids -- Physiological aspects, Sphingosine -- Physiological aspects, Cells -- Growth, Biological sciences, Chemistry
Abstract

Research has been conducted on the rat brain mitochondrial ceramidase. The effect of the structural ceramide analogues on this ceramidase has been investigated and described.

Published
2001

8. New Findings from University of California in the Area of Retinal Degeneration and Genetics Reported (Sphingolipid profile alters in retinal dystrophic P23H-1 rats and systemic FTY720 can delay retinal degeneration)

Subjects
University of California, Physiological aspects, Research, Physical fitness -- Physiological aspects, Retinal degeneration -- Research -- Physiological aspects, Sphingosine -- Physiological aspects, Sphingolipids -- Physiological aspects
Abstract

2016 JUN 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Eye Diseases and Conditions. According to news [...]

Published
2016

9. A novel function of sphingosine kinase 2 in the metabolism of sphinga-4,14-diene lipids. (Published February 14, 2020)

Subjects
Physiological aspects, Sphingosine -- Physiological aspects, Membrane lipids -- Physiological aspects, Sphingolipids -- Physiological aspects, Plant lipids, Proteins, Bonds (Securities), Editors, Lipids
Abstract

2020 APR 28 (NewsRx) -- By a News Reporter-Staff News Editor at Life Science Weekly -- By a News Reporter-Staff News Editor at Life Science Weekly - According to news [...]

Published
2020

10. New Leukemia Study Findings Recently Were Reported by Researchers at University of Virginia (Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl-1)

Subjects
University of Virginia. Cancer Center, Physiological aspects, Research, Apoptosis -- Physiological aspects, Lymphocytes -- Physiological aspects, Cancer research -- Physiological aspects, Sphingosine -- Physiological aspects, Leukemia -- Research -- Physiological aspects, Sphingolipids -- Physiological aspects, Membrane lipids, Plant lipids, Fate, Finance, Editors, Lipids
Abstract

2020 MAR 17 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Oncology - Leukemia have been published. According to news reporting originating [...]

Published
2020

11. Investigators from Medical College of Wisconsin Have Reported New Data on Metabolism

Subjects
Medical College of Wisconsin, Physiological aspects, Sphingosine -- Physiological aspects, Sphingolipids -- Physiological aspects, Medical schools -- Physiological aspects, Medical colleges -- Physiological aspects
Abstract

By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Metabolism. According to news reporting originating from Madison, Wisconsin, by NewsRx correspondents, research [...]

Published
2013

12. Studies from Molecular Signalling Laboratory Yield New Data on Insulin Resistance

Subjects
Physiological aspects, Genetic engineering -- Physiological aspects, Sphingosine -- Physiological aspects, Insulin resistance -- Physiological aspects, Membrane lipids -- Physiological aspects, Sphingolipids -- Physiological aspects
Abstract

By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in Nutritional and Metabolic Diseases and Conditions. According to news reporting originating in Adelaide, [...]

Published
2013

13. Researchers at University of Zurich Target Enzymes and Coenzymes

Subjects
Physiological aspects, Universities and colleges -- Physiological aspects, Phosphates -- Physiological aspects, Sphingosine -- Physiological aspects, Enzymology -- Physiological aspects, Enzymes -- Physiological aspects, Sphingolipids -- Physiological aspects
Abstract

By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Enzymes and Coenzymes is now available. According to news originating from Zurich, Switzerland, by [...]

Published
2012

14. Scientists at State University of New York Target Heart and Circulatory Physiology

Subjects
State University of New York, Physiological aspects, Universities and colleges -- Physiological aspects, Sphingosine -- Physiological aspects, Plant lipids -- Physiological aspects, Sphingolipids -- Physiological aspects, Scientists -- Physiological aspects
Abstract

A new study, 'Sphingolipids regulate [Mg2+]o uptake and [Mg2+]i content in vascular smooth muscle cells: potential mechanisms and importance to membrane transport of Mg2+,' is now available. According to recent [...]

Published
2011

15. Data on pancreatic cancer detailed by researchers at INSERM

Subjects
Diseases, Physiological aspects, Cancer treatment -- Physiological aspects, Pancreatic cancer -- Physiological aspects, Phosphotransferases -- Physiological aspects, Cancer research -- Physiological aspects, Sphingosine -- Physiological aspects, Sphingolipids -- Physiological aspects, Oncology, Experimental -- Physiological aspects, Cancer -- Care and treatment -- Research
Abstract

According to recent research from Toulouse, France, 'Defeating pancreatic cancer resistance to the chemotherapeutic drug gemcitabine remains a challenge to treat this deadly cancer. Targeting the sphingolipid metabolism for improving [...]

Published
2009

16. Studies from Medical University of South Carolina yield new information about lipid research

Subjects
Medical University of South Carolina, Physiological aspects, Universities and colleges -- Physiological aspects, Sphingosine -- Physiological aspects, Cytological research -- Physiological aspects, Sphingolipids -- Physiological aspects, Plant lipids -- Physiological aspects, Cell research -- Physiological aspects
Abstract

'Sphingolipids (SLs) are essential constituents of eukaryotic cells. Besides playing structural roles in cellular membranes, some metabolites, including ceramide, sphingosine, and sphingosine-1-phosphate, have drawn attention as bioactive signaling molecules involved [...]

Published
2009

17. New life sciences study findings have been reported from Washington University, Center for Cancer Research

Subjects
Sphingolipids -- Reports, Sphingolipids -- Physiological aspects, Sphingolipids -- Research, Universities and colleges -- Reports, Universities and colleges -- Physiological aspects, Universities and colleges -- Research, Sphingosine -- Reports, Sphingosine -- Physiological aspects, Sphingosine -- Research, Oncology, Experimental -- Reports, Oncology, Experimental -- Physiological aspects, Cancer -- Research, Cancer -- Reports, Cancer -- Physiological aspects
Abstract

Investigators publish new data in the report "Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania. In most eukaryotes, sphingolipids (SLs) are critical membrane components and signaling [...]

Published
2007

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