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Background: Myocardial perfusion imaging is commonly performed using SPECT, where both general‐purpose and dedicated scanners are available. A limitation with general‐purpose systems has been the inability to image dynamically since different projections are obtained far apart in time due to scanner rotation. Dedicated systems can have this capability since they acquire completely sampled projections (i.e., those with enough angular views for reconstruction) with short time frames. C‐SPECT, does not need any scanner or patient motion to obtain complete projections, allowing fast dynamics. When imaging fast dynamics, the optimal collimator settings are not necessarily the same as for static imaging, where longer acquisitions can be utilized. Thus, C‐SPECT offers adaptive collimation in the transverse and axial directions. Purpose: The performance of adaptation in the axial direction was characterized herein. Methods: The ratio of the resolution metric in high‐sensitivity mode to that in the high‐resolution mode, termed resolution boost factor, was determined. Analogously, the sensitivity boost factor was also determined. Comparisons were made with theory and simulations. Results: The boost factors for resolution and sensitivity, averaged over the 14 modules of the system, were determined to be 1.72 and 1.75, respectively. Conclusions: The boost factors, which ideally would be two, were between 10% and 15% below optimal values and tracked each other, suggesting mechanical challenges in the apparatus, such as incomplete closure of adjacent slats, but show reasonably successful adaptation between modes. [ABSTRACT FROM AUTHOR]

Purpose: In traditional multipinhole SPECT systems, image multiplexing — the overlapping of pinhole projection images — may occur on the detector, which can inhibit quality image reconstructions due to photon‐origin uncertainty. One proposed system to mitigate the effects of multiplexing is the synthetic‐collimator SPECT system. In this system, two detectors, a silicon detector and a germanium detector, are placed at different distances behind the multipinhole aperture, allowing for image detection to occur at different magnifications and photon energies, resulting in higher overall sensitivity while maintaining high resolution. The unwanted effects of multiplexing are reduced by utilizing the additional data collected from the front silicon detector. However, determining optimal system configurations for a given imaging task requires efficient parsing of the complex parameter space, to understand how pinhole spacings and the two detector distances influence system performance. Methods: In our simulation studies, we use the ensemble mean‐squared error of the Wiener estimator (EMSEW) as the figure of merit to determine optimum system parameters for the task of estimating the uptake of an 123I‐labeled radiotracer in three different regions of a computer‐generated mouse brain phantom. The segmented phantom map is constructed by using data from the MRM NeAt database and allows for the reduction in dimensionality of the system matrix which improves the computational efficiency of scanning the system's parameter space. To contextualize our results, the Wiener estimator is also compared against a region of interest estimator using maximum‐likelihood reconstructed data. Results: Our results show that the synthetic‐collimator SPECT system outperforms traditional multipinhole SPECT systems in this estimation task. We also find that image multiplexing plays an important role in the system design of the synthetic‐collimator SPECT system, with optimal germanium detector distances occurring at maxima in the derivative of the percent multiplexing function. Furthermore, we report that improved task performance can be achieved by using an adaptive system design in which the germanium detector distance may vary with projection angle. Finally, in our comparative study, we find that the Wiener estimator outperforms the conventional region of interest estimator. Conclusions: Our work demonstrates how this optimization method has the potential to quickly and efficiently explore vast parameter spaces, providing insight into the behavior of competing factors, which are otherwise very difficult to calculate and study using other existing means. [ABSTRACT FROM AUTHOR]

Purpose: One approach to preclinical single-photon emission computed tomography (SPECT) imaging that provides both high resolution and high sensitivity is based on imaging a mouse inside a collimating tube; many magnified pinhole projection images from a small target region, e.g., the heart, can be recorded simultaneously on multiple detectors with little multiplexing since each pinhole aperture's opening angle is restricted to view mostly the target organ. However, to obtain complete data for reconstruction, it may be necessary to scan the mouse through the target region of the tube. The authors are developing a different approach based on acquisition and reconstruction of both low-resolution and high-resolution projection data acquired sequentially through many pinholes embedded in two tungsten tube sections of different diameters, a "scout" section and a high-resolution section, placed end-to-end along the axis of a triple-head clinical SPECT scanner. This paper describes the design procedures used to determine the geometric parameters of two new collimator-tube sections, as well as one approach for joint reconstruction of data acquired from both sections. Methods: The high-resolution section was designed by projecting as many pinhole views of a simulated mouse heart as possible over each detector's camera, with no overlapping of heart projections and minimal overlapping between adjacent "hot" organ and cardiac projections. The authors then jointly optimized the geometric design of the scout section for a triple-detector camera system, as well as the number of maximum-likelihood expectation maximization (MLEM) iterations required to provide minimum mean-squared error of reconstructed voxel counts throughout a 7-cm axial range, with the constraints of fixed, 2.4-mm scout system resolution at the tube center for all apertures, limited multiplexing, and no detector motion. Simulated mouse projection data from both tube sections were then reconstructed to illustrate a simple approach for using high-resolution data to improve the whole-body scout images within a cylindrical region surrounding the heart. Results: The 2-cm-inner-radius high-resolution tube section accommodated 87 platinum-iridium pinhole inserts, each with a 0.3-mm square aperture; their radial distances from the centerline of the system ranged from 2.2 to 3.0 cm. The optimal radial distance to the closest scout pinhole and optimal number of MLEM iterations were 4.4 cm and 35 iterations, respectively, and the radial distances of the 39 scout pinholes ranged from 4.4 to 4.8 cm; aperture sizes ranged from 1.1 to 1.7 mm transaxially and 0.9-1.5mmaxially. After including data from the high-resolution section viewing the heart region into whole-body mouse reconstructions from scout data, the authors obtained high-resolution images of the heart, embedded within lower resolution images of the body, with minimal artifacts. Conclusions: The authors have optimized a dual-resolution collimator tube that provides both whole-body projections of a mouse and more targeted projections centered on the heart that can be jointly reconstructed to obtain high-resolution images of the heart embedded within lower-resolution whole-body images. [ABSTRACT FROM AUTHOR]

Advances in fabrication techniques, electronics, and mechanical cooling systems have given rise to germanium detectors suitable for biomedical imaging. We are developing a small-animal SPECT system that uses a double-sided Ge strip detector. The detector’s excellent energy resolution may help to reduce scatter and simplify processing of multi-isotope imaging, while its ability to measure depth of interaction has the potential to mitigate parallax error in pinhole imaging. The detector’s energy resolution is < 1\% FWHM at 140 keV and its spatial resolution is approximately 1.5 mm FWHM. The prototype system described has a single-pinhole collimator with a 1-mm diameter and a 70-degree opening angle with a focal length variable between 4.5 and 9 cm. Phantom images from the gantry-mounted system are presented, including the NEMA NU-2008 phantom and a hot-rod phantom. Additionally, the benefit of energy resolution is demonstrated by imaging a dual-isotope phantom with ^99mTc and ^123I without cross-talk correction. [ABSTRACT FROM PUBLISHER]