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We diagnosed 11 Guillain-Barre syndrome (GBS) cases among 71,904 COVID patients attended at 61 Spanish emergency departments (EDs) during the 2-month pandemic peak. The relative frequency of GBS among ED patients was higher in COVID (0.15 parts per thousand) than non-COVID (0.02 parts per thousand) patients (odds ratio [OR] = 6.30, 95% confidence interval [CI] = 3.18-12.5), as was the standardized incidence (9.44 and 0.69 cases/100,000 inhabitant-years, respectively, OR = 13.5, 95% CI = 9.87-18.4). Regarding clinical characteristics, olfactory-gustatory disorders were more frequent in COVID-GBS than non-COVID-GBS (OR = 27.59, 95% CI = 1.296-587) and COVID-non-GBS (OR = 7.875, 95% CI = 1.587-39.09) patients. Although COVID-GBS patients were more frequently admitted to intensive care, mortality was not increased versus control groups. Our results suggest SARS-CoV-2 could be another viral infection causing GBS. ANN NEUROL 2020

Two species of the family Eomyidae are identified in the Early Miocene localities of the Araia d’Alcora outcrop (Ribesalbes-Alcora Basin, Iberian Peninsula): Ligerimys florancei and Ligerimys ellipticus. The first is rarer than the second, which is one of the most abundant mammals in the Ribesalbes-Alcora Basin assemblages. Due to its abundance, we are able to describe its variability in dental morphology, showing characteristics never previously observed, including the presence of a mesoloph or other features previously described only in ancient assemblages of this species, such as the presence of the anteroloph, which appears in younger assemblages in the Araia sequence. Furthermore, based on the eomyids, we divide the record of the Campisano Ravine section into two long local biozones, depending on the species present. In addition, each local biozone is divided into two smaller sub-biozones, depending on the abundance of each species. We retrospectively compare and correlate the assemblages studied here with other Ligerimys assemblages from the other basins in the Iberian Peninsula. We classify these sites based on the abundance and species of the genus Ligerimys. Additionally, we discuss the palaeoecological preferences of these species, RIVISTA ITALIANA DI PALEONTOLOGIA E STRATIGRAFIA , V. 127 N. 3 (2021)

BACKGROUND: In patients with acute decompensated heart failure (ADHF), both natriuretic peptides and renal impairment predict adverse outcomes. Our aim was to evaluate the complementary prognosis role of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) and the newly developed Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) equations based on cystatin C (CysC) for glomerular filtration rate (GFR) estimation in ADHF patients. HYPOTHESIS: Renal impairment assessed by CysC‐based CKD‐EPI equations and natriuretic peptides have complementary prognostic value in ADHF patients. METHODS: The study included 613 consecutive patients presenting with ADHF. At admission, plasma levels of NT‐proBNP and CysC were determined. The GFR was estimated using CysC‐based CKD‐EPI equations. The primary endpoint was death from any cause and heart failure readmission. RESULTS: During the median follow‐up of 365 days (interquartile range, 227–441 days), 323 patients (0.65 %patient‐year) died or were readmitted for heart failure. After multivariate adjustment, estimated GFR 3251 pg/mL were independent predictors of adverse outcomes (P < 0.01). The combination of GFR 3251 pg/mL was associated with the highest risk of adverse outcomes. Furthermore, reclassification analyses demonstrated that use of both NT‐proBNP and CysC‐based CKD‐EPI equations resulted in improving the accuracy for adverse outcomes prediction. CONCLUSIONS: In patients with ADHF, the combination of NT‐proBNP with estimated GFR using CysC‐based CKD‐EPI equations better predicts outcomes than either parameter alone and adds valuable complementary prognosis information to other established risk factors.