1. Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex.
- Author
-
Domanski APF, Booker SA, Wyllie DJA, Isaac JTR, and Kind PC
- Subjects
- Action Potentials, Animals, Computer Simulation, Disease Models, Animal, Fragile X Mental Retardation Protein genetics, Fragile X Syndrome genetics, Glutamic Acid metabolism, Male, Mice, Mice, Knockout, Patch-Clamp Techniques, Phenotype, Somatosensory Cortex cytology, Fragile X Syndrome metabolism, Neurons metabolism, Somatosensory Cortex metabolism, Synapses metabolism
- Abstract
Sensory hypersensitivity is a common and debilitating feature of neurodevelopmental disorders such as Fragile X Syndrome (FXS). How developmental changes in neuronal function culminate in network dysfunction that underlies sensory hypersensitivities is unknown. By systematically studying cellular and synaptic properties of layer 4 neurons combined with cellular and network simulations, we explored how the array of phenotypes in Fmr1-knockout (KO) mice produce circuit pathology during development. We show that many of the cellular and synaptic pathologies in Fmr1-KO mice are antagonistic, mitigating circuit dysfunction, and hence may be compensatory to the primary pathology. Overall, the layer 4 network in the Fmr1-KO exhibits significant alterations in spike output in response to thalamocortical input and distorted sensory encoding. This developmental loss of layer 4 sensory encoding precision would contribute to subsequent developmental alterations in layer 4-to-layer 2/3 connectivity and plasticity observed in Fmr1-KO mice, and circuit dysfunction underlying sensory hypersensitivity.
- Published
- 2019
- Full Text
- View/download PDF