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3 results on '"Safonova OV"'

1. [Restoration of the quality of life by eliminating and prevention of heartburn by alginate: results of multicenter study "VIA APIA"].

Author

Lazebnik LB, Bordin DS, Masharova AA, Dzhulaĭ GS, Butov MA, Abdulkhakov RA, Eremina EIu, Tarasova LV, Safonova OV, Firsova LD, and Kozhurina TS

Subjects
Adult, Alginates administration & dosage, Aluminum Hydroxide administration & dosage, Antacids administration & dosage, Drug Combinations, Female, Gastroesophageal Reflux diagnosis, Gastroesophageal Reflux prevention & control, Gastroesophageal Reflux psychology, Heartburn diagnosis, Heartburn prevention & control, Heartburn psychology, Humans, Male, Prospective Studies, Severity of Illness Index, Silicic Acid administration & dosage, Sodium Bicarbonate administration & dosage, Surveys and Questionnaires, Suspensions, Treatment Outcome, Alginates therapeutic use, Aluminum Hydroxide therapeutic use, Antacids therapeutic use, Gastroesophageal Reflux drug therapy, Heartburn drug therapy, Quality of Life psychology, Silicic Acid therapeutic use, Sodium Bicarbonate therapeutic use
Abstract

Was conducted a muIticenter study VIA APIA, in which the impact of gaviscon forte (suspension) on symptoms, general state and quality of life of 148 patients (male 53, female 95, age 42.9 +/- 15.6) with gastroesophageal reflux disease (GERD) were investigated. The patients had undergone clinical evaluation of dynamics of GERD symptoms (Likert scale), general state (Visual Analogue Scale, questionnaire SAN) and quality of life (SF-36). It was shown that 14-days treatment with gaviscon forte provided symptoms relief in 84.5% patients and conducted improvement of general state and quality of life. Gaviscon forte recommended as drug of choice in initial treatment for the first time visited patient with heartburn before endoscopy and for pathogenetic treatment of typical reflux syndrome.

Published
2010

2. [Evaluation of action, efficacy, and onset dynamics of a single dose of alginates in patients with heartburn and GERD].

Author

Bordin DS, Masharova AA, Firsova LD, Kozhurina TS, and Safonova OV

Subjects
Adult, Alginates administration & dosage, Aluminum Hydroxide administration & dosage, Antacids administration & dosage, Cross-Over Studies, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Combinations, Female, Gastroesophageal Reflux psychology, Heartburn psychology, Humans, Male, Middle Aged, Quality of Life psychology, Silicic Acid administration & dosage, Sodium Bicarbonate administration & dosage, Taste, Time Factors, Treatment Outcome, Alginates therapeutic use, Aluminum Hydroxide therapeutic use, Antacids therapeutic use, Gastroesophageal Reflux drug therapy, Heartburn drug therapy, Silicic Acid therapeutic use, Sodium Bicarbonate therapeutic use
Abstract

We conducted a crossover study, in which the efficacy and the onset of action of a single dose of Gaviscon (suspension) and Gaviscon forte (suspension) in 52 patients with heartburn of moderate intensity and gastroesophageal reflux disease (GERD) have been investigated. The average age of the patients was 44.0 +/- 17.3-years-old. The patients have undergone clinical evaluation of intensity of GERD symptoms and psychological assessment (questionnaires SF-36, SMOL, LOBI). Alginates' effects and qualities were evaluated using stopwatch technique, clinical examination, and organoleptic assessment. Primary sensation of a cooling (soothing) effect after use of a single dose of Gaviscon has been reported in 65.7 seconds (on average), and Gaviscon forte--in 66.1 seconds. Fourty three (82.7%) patients with heartburn have described the effects of both medications as "instant" cooling effects. Heartburn was relieved in 3.3 minutes in all patients after a single dose of Gaviscon, and in 3.6 minutes in 51 (98.1%) patients who have received a single dose of Gaviscon forte. Organoleptic qualities averaged at 3.6 points (on a scale of 1-5) for Gaviscon, and at 3.5 points for Gaviscon forte. Assessment of mental status of the patients suggested that a "delayed" effect of the medications in relieving heartburn in some patients may have occurred due to possible physical disadaptation.

Published
2009

3. [Estimation of efficiency of alginate-raft barrier in treatment of gastroesophageal reflux disease].

Author

Bordin DS, Masharova AA, Firsova LD, Kozhurina TS, and Safonova OV

Subjects
Alginates administration & dosage, Alginates adverse effects, Aluminum Hydroxide administration & dosage, Aluminum Hydroxide adverse effects, Antacids administration & dosage, Antacids adverse effects, Drug Administration Schedule, Drug Combinations, Female, Gastric Acid metabolism, Gastric Acidity Determination, Gastric Mucosa metabolism, Gastroesophageal Reflux diagnosis, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Quality of Life, Silicic Acid administration & dosage, Silicic Acid adverse effects, Sodium Bicarbonate administration & dosage, Sodium Bicarbonate adverse effects, Alginates therapeutic use, Aluminum Hydroxide therapeutic use, Antacids therapeutic use, Gastric Mucosa drug effects, Gastroesophageal Reflux drug therapy, Silicic Acid therapeutic use, Sodium Bicarbonate therapeutic use
Published
2008

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