1. Exploring the Interplay Between Adversity, Neurocognition, Social Cognition, and Functional Outcome in People With Psychosis: A Narrative Review
- Author
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Rodriguez, Victoria, Aas, Monica, Vorontsova, Natasha, Trotta, Giulia, Gadelrab, Romayne, Rooprai, Navneet Kaur, Alameda, Luis, [Rodriguez,V, Aas,M, Vorontsova,N, Gadelrab,R, Rooprai,NK, Alameda,L] Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom. [Aas,M] NORMENT Centre for Psychosis Research, Oslo University Hospital, University of Oslo, Oslo, Norway. [Aas,M] Division of Mental Health and Addiction, Department of Mental Health Research and Development, Vestre Viken Hospital Trust, Drammen, Norway. [Vorontsova,N] Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom. [Trotta,G] Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, London, United Kingdom. [Alameda,L] Service of General Psychiatry, Treatment and Early Intervention in Psychosis Program, Lausanne University Hospital (CHUV), Lausanne, Switzerland. [Alameda,L] Departamento de Psiquiatría, Centro Investigación Biomedica en Red de Salud Mental (CIBERSAM), Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, Spain., and This work was supported by the Swiss National Science Foundation (Grant P2LAP3_171804 to LA). VR was funded by a Ph.D. scholarship supported by Lord Leverhulme’s Charitable Trust and by the Velvet Foundation. This paper represents independent research part funded by the NARSAD Young Investigator Award to MA (#22388).
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Revisión ,Cognición ,Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition [Medical Subject Headings] ,Trastornos psicóticos ,Functional outcome ,Pruebas de estado mental y demencia ,Social cognition ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Memory::Memory, Short-Term [Medical Subject Headings] ,Psychiatry and Psychology::Mental Disorders::Schizophrenia and Disorders with Psychotic Features::Psychotic Disorders [Medical Subject Headings] ,Childhood adversity ,Pacientes ,Persons::Persons::Age Groups::Child [Medical Subject Headings] ,Neurocognition ,Cognición social ,Publication Type::Publication Formats::Journal Article::Review [Medical Subject Headings] ,Narrative review ,Psychiatry and Psychology::Psychological Phenomena and Processes::Psychological Theory::Theory of Mind [Medical Subject Headings] - Abstract
History of adversity is associated with subsequent psychosis, and with a spectrum of cognitive alterations in individuals with psychosis. These cognitive features go from neurocognitive aspects as working memory and attention, to complex social cognitive processes as theory of mind and emotional perception. Difficulties in these domains impact patients' social and occupational functioning, which has been shown to be more impaired in those previously exposed to childhood trauma. However, the interplay between adversity, neurocognition, and functioning is yet poorly understood. This narrative review aims to explore the evidence on whether deficits in neurocognitive and social cognitive domains may act as possible putative mechanism linking adversity with functioning in people with psychosis. We show available evidence supporting the link between adversity and poorer functioning in psychosis, especially in chronic stages; and replicated evidence suggesting associations of social cognition and, to a lesser extent, neurocognition with impairment in functioning in patients; although there is still an important gap in the literature testing particularly deficits in social cognition as mediator of the link between adversity and functional decline in psychosis. Targeting interventions focusing on neurocognition and social cognition in individuals with adversity and psychosis seems important, given the severe deterioration of these patients in these domains, although more research is needed to test whether such treatments can specifically improve functioning in individuals with psychosis and adversity. Literature aiming to understand the determinants of functional outcome should consider the pervasive impact of childhood adversity, and its related effects on cognition. Yes
- Published
- 2021