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In a case-control study on lung cancer, risk was analysed in relation to smoking habits and frequency of vegetable and fruit consumption. Lung cancer cases in West Sweden and population controls were interviewed using a questionnaire where the frequency of consumption of dietary items and smoking habits were assessed. The material presented comprises 177 female and 359 male confirmed cases of lung cancer and 916 population controls. There was a dose-response relationship in regard to the number of cigarettes smoked and the number of years smoked, the latter factor being more important. After adjustment for number of cigarettes smoked/day and number of years smoked, the risk for those who seldom consumed vegetables was about twice of that among those who consumed vegetables frequently, both among nonsmokers, smokers and former smokers. This risk increase in relation to vegetable consumption also was present for different smoking categories. A similar tendency, although less pronounced, was found for fruit consumption. The results demonstrate that dietary factors are related to the risk for lung cancer, although smoking is the dominant risk factor., (Copyright 2005 Wiley-Liss, Inc.)

In a prospective case-control lung cancer study in the west of Sweden, the relationship between lung cancer, smoking and dietary factors was investigated. Suspected cases were collected from pulmonary units at two central hospitals in the area investigated and population controls of the same age and sex were selected from registers. The majority of cases and controls were interviewed by specially trained nurses, using a food frequency questionnaire. The lung cancer diagnosis (ICD 7, 162.1) was made using data from the local cancer register. In an analysis based on 308 cases and 504 controls, a dose-related increase in lung cancer risk for smokers was found, although no significant risk was found for males smoking 1-10 cigarettes/day for less than 20 years. A lower consumption of vegetables was related to a higher risk, both for smokers and nonsmokers. A higher consumption of milk was related to an increased risk.

One hundred and twenty-five patients with asthma were questioned on the character of their symptoms in connection with cessation of tobacco smoking. Eighteen out of fifty-nine patients who stopped smoking, reported worsening of their symptoms. The pathogenesis behind this effect may be the effect of tobacco smoke on the immune system particularly macrophages and T cells.