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Your search keyword '"Hansaem Jeong"' showing total 4 results
Start Over Author "Hansaem Jeong" Topic small interfering rna
4 results on '"Hansaem Jeong"'

1. Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

Author

Eun Hye Jeong, Cheol Am Hong, Hansaem Jeong, Bora Jang, and Hyukjin Lee

Subjects
Small interfering RNA, Nanotechnology, Conjugated system, Microscopy, Atomic Force, Catalysis, Cell Line, chemistry.chemical_compound, Folic Acid, Dna nanostructures, Materials Chemistry, Humans, Gene silencing, RNA, Small Interfering, DNA synthesis, Chemistry, Metals and Alloys, DNA, General Chemistry, Nanostructures, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Microscopy, Fluorescence, Rolling circle replication, Ceramics and Composites, Biophysics, RNA Interference, Nucleic Acid Amplification Techniques, Conjugate
Abstract

Inspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of DNA nanostructures using a single-stranded circular DNA template. The amplified DNA nanostructures have shown efficient delivery of folic acid (FA) conjugated siRNAs into KB cells with a dose dependent gene silencing.

Published
2014
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2. Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells

Author

Bora Jang, Seonki Hong, Ho Yeon Lee, Hansaem Jeong, Eun Hye Jeong, Hyukjin Lee, Haeshin Lee, and Ji Hyun Ryu

Subjects
Cytoplasm, Small interfering RNA, Surface Properties, Flavonoid, Metal Nanoparticles, Nanotechnology, Catalysis, Materials Chemistry, Humans, Gene silencing, Gene Silencing, Particle Size, RNA, Small Interfering, Flavonoids, chemistry.chemical_classification, Regulation of gene expression, Chemistry, fungi, Gene Transfer Techniques, Temperature, Metals and Alloys, food and beverages, General Chemistry, Photothermal therapy, Photochemical Processes, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Gold nanoshells, Ceramics and Composites, Surface modification, Gold, HeLa Cells
Abstract

Polymer gold nanoshells (PGNs) are prepared by a novel plant-inspired flavonoid surface modification method. The PGNs show dramatic photothermal properties, which can facilitate the endosomal escape and delivery of siRNA into the cytoplasm of cells. Efficient gene silencing has been achieved using siRNA immobilized PGNs, suggesting the potential applications of in vitro gene regulation by an external NIR stimulus.

Published
2014
Full Text
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3. Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells.

Author

Eun Hye Jeong, Hansaem Jeong, Bora Jang, Ho Yeon Lee, Hyukjin Lee, Ji Hyun Ryu, Seonki Hong, and Haeshin Lee

Subjects
SMALL interfering RNA, PHOTOTHERMAL effect, FLAVONOIDS, GOLD nanoparticles, POLYMERS, GOLD coatings
Abstract

Polymer gold nanoshells (PGNs) are prepared by a novel plant-inspired flavonoid surface modification method. The PGNs show dramatic photothermal properties, which can facilitate the endosomal escape and delivery of siRNA into the cytoplasm of cells. Efficient gene silencing has been achieved using siRNA immobilized PGNs, suggesting the potential applications of in vitro gene regulation by an external NIR stimulus. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

4. Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates.

Author

Cheol Am Hong, Bora Jang, Eun Hye Jeong, Hansaem Jeong, and Hyukjin Lee

Subjects
NANOSTRUCTURES, SMALL interfering RNA, CIRCULAR DNA, GENE silencing, FOLIC acid, ATOMIC force microscopy
Abstract

Inspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of DNA nanostructures using a single-stranded circular DNA template. The amplified DNA nanostructures have shown efficient delivery of folic acid (FA) conjugated siRNAs into KB cells with a dose dependent gene silencing. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

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