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There are various references to sensitization to beryllium in the literature. Since introducing a patch testing series for patients with suspected sensitization to metals, we have found 3 cases of sensitization to beryllium. Of these 3 cases, we regard the first 2 having relevant sensitization. Beryllium chloride (1% pet) was positive in 3 patients and negative in 150 controls. [ABSTRACT FROM AUTHOR]

Cocoamidopropylbetaines are surfactants frequently used on cosmetics. We have evaluated the irritant capacity of 3 different qualitities of cocoamidopropylbetaine, using the following method: patch tests have been carried out with 5 different dilutions in 67 patients and the results read at 2 days by noninvasive methods (direct visualization, transepidermal water loss (TFWL), laser Doppler flowmetry (LDF)). The results with the 3 methods were concordant. However, the results with the different concentrations were paradoxical, as irritancy did not increase at higher concentrations.We have tried to explain this by the fact that these substances contain by-products (free amidoamine and sodium monocholoroacetate), the concentrations tested all being above the critical micelle concentration and therefore containing both micelles and monomer. Finally, we believe that noninvasive methods such as TEWL and LDF could be of great use in the evaluation of irritant contact dermatitis. [ABSTRACT FROM AUTHOR]

Patch tests with the GEIDC standard series of allergens, and with 8 washers made of copper, nickel, nickel-palladium, palladium, brass, bronze, gold and iron, were carried out in 964 consecutive patients who complained of intolerance to metals and in 200 controls who did not. All subjects were also questioned as to personal and family history of atopy, occupational contact and intolerance to gold. The results provide support for the substitution of nickel in imitation jewelry with metals such as palladium or bronze. [ABSTRACT FROM AUTHOR]

The article reports the development of contact dermatitis by dipivefrine. Glaucoma is a chronic, progressive, optic neuropathy for which there is a wide variety of effective, topical drugs. These agents include timolol, that evolved into a negative reaction at the 4-day-reading. However, given their closely related structures, the researchers do not rule out this risk and advise against its use in the future. Systemic, ophthalmic and cutaneous reactions have been attributed to delivery vehicle components, like benzalconium chloride, disodium edetate, bisulfite etc.

We report a fixed drug eruption caused by a syrup containing sodium benzoate. Our patient gave a positive reaction to a patch test and to a provocation test after 15 h ingestion, but no patch test reaction in the interdigital area where the patient had previous lesions. [ABSTRACT FROM AUTHOR]

This article presents a case study related to contact dermatitis from oak moss. A 30-year-old housewife presented in March 1990 with a 15-day history of dark-brown pigmented lesions in the left periocular region one month previously. She had developed erythematous lesions on both cheeks, more severe on the left, with labial and left palpebral eczema, which had disappeared spontaneously. The only cosmetics she used were an eye shadow and a moisturizing cream. It was not possible to obtain information as to the possible presence of atranorin or oak moss in the fragrance of the patient's moisturizing cream. The manufacturer of the eye shadow denied the presence of either in its composition.

Allergic contact dermatitis and photoallergic contact dermatitis from NSAID, especially ketoprofen, have both been reported, most recently mainly from Europe and the Mediterranean area. The majority of cases of dermatitis from ketoprofen are photoallergic, those of allergic contact dermatitis being less frequent. The case under study has two particular features. It is a case of allergic contact dermatitis in which, in spite of the possible solar influence, a patch test without irradiation was strongly positive. The intense clinical picture completely spared the area of skin initially atrophied by excessive application of a potent topical steroid. This phenomenon could not be further substantiated as the patient refused a biopsy of the apparently unaffected atrophic area. Otherwise, electron microscopy for Langerhans cells could have been performed.

During an 8-month period, the authors saw 16 workers from a chemical factory that manufactures ranitidine base. Ranitidine base is obtained by distillation in reactors in 4 different phases. The 16 patients were 11 office workers, 2 male chemists, 2 male maintenance workers and 1 female secretary. The authors were able to patch test 11 of the 16 patients. The remainder declined to be patch tested. Patch testing with standard series was carried out in these 11 patients. From the patch-test results, it was concluded that the epidemic of occupational contact dermatitis was caused by ranitidine base.

This article presents a case study related to contact dermatitis from swimming goggles. A 42-year-old housewife went swimming on medical advice once a week. 2 weeks previously, an eyelid edema had begun 5 hours after wearing black rubber swimming goggles. The edema disappeared spontaneously after 24 hours. A week later, after wearing the same goggles, the patient immediately noticed intense itching. An intense eczema with erythematous, scaly, exudative lesions and evident eyelid edema appeared 2 hours later.

This article presents 3 case reports related to contact dermatitis to thiourea. The first case is of a 41-year-old housewife who suffered from tendinitis of the right elbow, which was treated with an ointment. Redness and itching appeared in the area of application. The second case is of a 39-year-old housewife who had an operation on the right knee for arthritis 10 months previously. A bone implant was grafted from the ankle and held in place by 2 stainless steel clips. Due to intolerance and rejection, the clips were removed after six months.

This article presents a case report and associated medical comments of two patients with allergic contact dermatitis from geraniol, one of the components of the ICDRG fragrance mixtures. Medical examination of one of the patients through standard patch tests were found negative except to fragrance mixtures. Some additional test have been performed with the help of constituents of several ointments used by the patient and with 17 other proprietary ointments. Skin sensitization to these ointments were observed and analysed. It is analysed that it is often difficult to identify the causes of dermatitis from perfumes.

This article focuses on a study related to the contact dermatitis from geraniol in Bulgarian rose oil. In the present case a 41-year-old female doctor, with intolerance to imitation jewellery 15 years, gave a history that three months ago after dyeing her hair, she had experienced intense itching of the scalp, treated with oral antihistamines and topical corticosteroids. Study shows that two major components were citronellol and geraniol, which explains the positivity to the latter, contained at approximately 20% in Bulgarian rose oil.

This article presents case study of a 47-year-old woman who developed eczematous patches on the sides of her nose. It was found out that 4 months back patient bought some new sun glasses. For patch testing the Italian company gave the composition of glasses to the doctors. In these glasses the principal component was polycarbonate macrolon bayer. On patch testing, patient showed positive reaction to polycarbonate macrolon bayer. Therefore, the patient stopped wearing the glasses and the lesions were cured when treated with a corticostcroid cream.

Allergic contact dermatitis in metalworkers has increasingly been reported in recent years. Although many different compounds added to cutting oils can be sensitizers, biocides are the most common, most are water-soluble and very stable. In Spain. the most widely used are the Grotans and the Biobans. The results of patch testing in patients with occupational contact dermatitis from the metalworking industry in 2 contact dermatitis clinics in Barcelona, Spain during 1990 and 1991 are reported in the article.

A 13 year old boy developed itchy maculo-rythematous lesions on the dorsum of the feet and toes, with hyperkeratotic lesions on the soles, continuing in outbreaks depending on treatment, always worsening in the summer. He always wore sports shoes, trainers or deck shoes. It was concluded that the patient had a footwear dermatitis caused exclusively by rubber accelerators, and that the initial patch testing had caused an angry back but not an angry thigh.

This article presents a case study related to shoe contact dermatitis. A 39-year-old female began to wear a special orthopaedic shoe. 2 months later, she presented with acute contact eczema localized to the area of the foot in contact with the shoe. The lesions were erythematous, vesicular, exudative, intensely itchy and very resistant to treatment. She had no personal or family history of atopy. Standard patch test were positive to cobalt chloride and nickel sulphate. Test with the pieces of the interior and exterior of the shoe were intensely positive in the patient.

A 62-year-old woman developed 6 months ago conjunctivitis and red scaly bilateral eyelid lesion, with intense itching, resistant to treatment. More recently eyelid edema appeared, more evident on the left side. She used an ophthalmic ointment and an oral antihistamine for the skin lesions. These were positive eyedrops containing timolol maleate. It was found that the majority of conjunctival reactions to pharmaceutical preparations with timolol are not due to the substance itself, but due to the preservative benzalkonium chlorhydrate.

This article focuses on a study related to the nickel dermatitis from an infusion needle. An obese 19-year-old woman, with a personal and family history of atopy had known sensitivity to nickel since the age of 12 years. She had insulin-resistant diabetes for six years. An insulin infusion pump was fitted six months previously. One month later, itchy papules appeared round the needle site and they increased to form a plaque 10 cm in diameter. During the test, this needle was not attracted to a magnet and no cobalt, tin or copper was detected.

This article focuses on a study related to methyl methacrylate prosthesis dermatitis. Three years ago, a 31-year-old man suffered a fracture of the left femur after a car accident. 12 days after the operation, he developed osteomyelitis, which was treated with antibiotics for five months. The antibiotic is released through pores of the plastic material to act directly on the infected area. 15 days after the implantation, an eczematous patch appeared round the fistula on the thigh. After removal of chain of beeds containing different chemical compounds, the eczematous lesions disappeared.