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Summary Background Imatinib mesylate ( IM) is a phenylaminopyrimidine that represents the first-line treatment for chronic myeloid leukemia ( CML), Philadelphia chromosome-positive. It acts as a potent and selective inhibitor of the bcr-abl fusion protein by a competitive inhibition at the adenosine triphosphate-binding site of the enzyme, which leads to the inhibition of tyrosine phosphorylation of the proteins involved in bcr-abl signal transduction. IM is generally well tolerated and usually provokes only mild side effects consisting of nausea, myalgia, edema and muscle cramps. Observation This is a report of a patient affected by CML, who developed a photoinduced dermatitis and an oral lichenoid reaction associated with IM treatment. The lesions were resolved, thanks to the withdrawal of the therapy, and they relapsed after the reintroduction of IM, confirming the drug-induced pathogenesis. Conclusion Skin changes are the most common non-hematologic side effects to IM treatment and are usually dose dependent. In particular, patients with IM therapy reported a lightening and depigmentation of the skin, that may alter the skin protection against ultraviolet exposure, with a possible subsequent intolerance to sun exposure, as reported in our patient, and higher risk of skin cancer. They are frequently self-limited or easily managed; nevertheless, in some cases, the therapy needs to be discontinued or may only be continued with concomitant oral steroid. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 50-year-old man who was diagnosed with human herpesvirus, who shows papular rashes. The patient skin biopsies shows interface dermatitis with superficial preivascular lymphocytic infiltration. The patient was administered with serological testing and blood samples. It also notes that the herpesvirus belongs to the beta-herpesvirus subfamily.

This article presents a case report of acute irritant contact dermatitis from Agave americana L. Several hundred plants have been described as causing dermatitis. Not all cases reach medical attention. Agave americana L. is one of the 300 species of agave of the agavaceae family, plants to which grow in hot, arid and semi-arid regions, native to Mexico. The plant dies when it flowers, that is when it produces a tall central bud. In Mexico, it is used to prepare a national drink. The agavaceae contain numerous steroid sapogenins, made of 27 carbon atoms.