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Background: Patch testing is the standard method to diagnose contact allergy. Patches are applied for 48 hours, which is inconvenient to patients in tropical weather. Therefore, we evaluated different patch test occlusion times with increased concentrations of an allergen to determine if occlusion time can be reduced without compromising patch test reactivity. Methods: Patch test positive patients with parthenium dermatitis were enrolled and patch tested using five different concentrations (10%, 4%, 2%, 1%, and 0.5%) of parthenium extract. The patches were applied in triplicate. The first set was removed after 12 hours, whereas the second and third sets were removed after 24 and 48 hours, respectively. Readings were performed at 24, 48, and 96 hours. Results: Fifty patients with parthenium dermatitis were included. The positive patch test reaction rates were comparable in all three sets at 24‐ and 48‐hour readings irrespective of the occlusion time. All were positive, with 10%, 4%, and 2% concentrations at 96‐hour reading with an occlusion time of 12 hours. Conclusion: An occlusion time of 12 hours seems adequate to elicit positive patch test reaction at a 96‐hour reading if the concentration of patch test allergen can be increased, that is, from 1% to 2% in these patients. [ABSTRACT FROM AUTHOR]

Keywords: ciclosporin; Parthenium dermatitis; treatment EN ciclosporin Parthenium dermatitis treatment 134 136 3 01/28/21 20210201 NES 210201 I Parthenium hysterophorus i , a weed of the Compositae family, is the most common cause of airborne contact dermatitis in India.1 It is a chronic debilitating illness resulting in high morbidity. Ciclosporin, an anti-inflammatory and immunosuppressant, has been shown to be effective in two patients with I Parthenium i dermatitis.4 In this case series, we evaluated clinical efficacy and safety of ciclosporin in patients with parthenium dermatitis. Thus, ciclosporin appears to be an effective drug in treatment of patients with I Parthenium i dermatitis, particularly when corticosteroids and azathioprine are contraindicated. [Extracted from the article]

Abstract: Background: Many patients with dermatitis over photo‐exposed body areas are positive to many contact allergens and have a pre‐existing allergic contact dermatitis. Methods: This study included patients who presented to a tertiary centre in India with dermatitis on photo‐exposed body areas suspected of chronic actinic dermatitis. Their detailed histories were recorded and cutaneous and systemic examinations were performed. Patch testing was done in all the patients and photo‐patch testing was carried out in 86 patients. Results: Altogether 101 patients were included (69 males, 32 females). The most common presentation was lichenified hyperpigmented plaques on the photo‐exposed sites. Photosensitivity was recorded in 64 (63%) patients and summer exacerbation in 52 (52%). Exposure to the Parthenium hysterophorus weed was recorded in 70 (69%) patients, 27 (26.7%) had a history of hair dye application and 20 (20%) had a history of atopy. Photo‐patch test was positive in 11 (12.8%) patients and patch testing was positive in 71 (70%). Parthenium hysterophorus was the most common allergen implicated and was positive in three (4%) photo‐patch and 52 (52%) patch tests. Other positive photo‐patch test allergens were perfume mix, balsam of Peru, thiuram mix, Compositae mix and promethazine hydrochloride. Other common patch test allergens were parthenolide, colophony, fragrance mix and p‐phenylenediamine (PPD) base. Conclusion: In the Indian population parthenium and perfume mix are the most common photoallergens in patients with dermatitis over photo‐exposed areas, while parthenium, colophony, fragrance mix and PPD are the common positive allergens. [ABSTRACT FROM AUTHOR]

A 70-year-old woman presented with generalized reticulate pigmentation, scarring alopecia, and few discrete, violaceous plaques over the trunk and forearm. Dermoscopic evaluation of the reticulate plaque showed reticulate hyperpigmentation with multiple telangiectasias, and skin biopsy showed lichenoid interface dermatitis with marked pigment incontinence. Thus, a final diagnosis of poikiloderma due to lichen planus pigmentosus was considered. [ABSTRACT FROM AUTHOR]

The article discusses the use of tacrolimus ointment under facial occlusion using cling film for the treatment of chronic actinic dermatitis (CAD) cases. Topics discussed include treatment of patients taking doses of oral corticosteroid and azathioprine, inhibition of inflammatory dendritic epidermal cells and prescription of sunscreens and oral antihistamines for topical treatment.

The article focuses on the effect of oral betamethasone on patch test reactivity in patients who are allergic to the plant Parthenium hysterophorus. It mentions that systemic corticosteroids are responsible for suppression of patch test reactivity. It presents the results of pre-betamethasone treatment and post-betamethasone treatment patch test on patients with clinical diagnosis of parthenium dermatitis.

The article reports that azathioprine does not influence the patch test reactivity in Parthenium dermatitis. Researchers studied 60 clinically diagnosed, patch test-confirmed patients with Parthenium dermatitis, who were eligible for azathioprine treatment. The patch testing with an aqueous extract of the plant antigen was performed before initiation of azathioprine treatment.