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Background: Atopic dermatitis (AD) is a prevalent chronically relapsing inflammatory skin disease of childhood. However, little is known about self‐reported trigger factors, impact on daily life and factors associated with AD severity. Methods: A nationwide questionnaire study of children in Denmark with hospital‐diagnosed AD in the time period 2014–2018. The web‐based questionnaire was completed by the legal parents. AD severity was assessed using Patient‐Oriented Eczema Measure (POEM) tool. Results: Of 3438 invited parents, 1343 (39%) completed the questionnaire. Factors associated with severe AD were onset during the first 6 months of life, onset of AD on multiple body regions, a history of hay fever, female sex and low maternal educational level. Staying home from daycare or school due to AD, concentration problems and sleep disturbances in the child were more frequently reported by parents to children with severe AD. Overall, 90% reported at least one AD trigger factor, and all were more frequently reported in children with severe AD. The three most commonly reported trigger factors were cold weather (51.9%), chlorinated water (35.7%) and warm weather (30.2%). Conclusions: We identified factors associated with severe AD in childhood, the impact on daily life, as well as the most common self‐reported triggers of AD. These findings may be valuable in clinical practice to inform about prognosis and educate families about trigger avoidance. [ABSTRACT FROM AUTHOR]

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels and scarring involving the intertriginous regions. Recent next‐generation sequencing (NGS) studies suggest genera such as Prevotella spp., Peptoniphilus spp. and Porphyromonas spp. are associated with chronic and early HS lesions. However, a systematic investigation of the bacterial microbiome in HS tunnels remains unexplored using NGS. Objective: We aimed to investigate the bacterial composition of the luminal white gelatinous material found in HS tunnels using NGS. Methods: An exploratory study of patients with diagnosis of HS (n = 32) with tunnels. The tunnels were present either in the groin (n = 17) or in the axilla (n = 15). During deroofing of the tunnels, a sterile E‐swab was taken of the luminal gelatinous material. The samples were investigated using NGS targeting 16S ribosomal RNA. Results: The skin microbiome was characterized in 32 HS patients. Overall, five microbiome types were identified: Porphyromonas spp. (type I), Corynebacterium spp., (type II), Staphylococcus spp. (type III), Prevotella spp. (type IV) and Acinetobacter spp (type V). Porphyromonas spp. (type I) and Prevotella spp. (IV) were the most frequent genera found the tunnels. Conclusion: This study points to a potential association between the presence of certain anaerobic bacteria (Porphyromonas spp., Prevotella spp.) and HS tunnels. It may be speculated that these two genera are associated with the pathogenesis in HS either as drivers or as biomarkers. [ABSTRACT FROM AUTHOR]

Background Chronic inflammatory diseases may be associated with anaemia of inflammation. Hidradenitis suppurativa is a chronic inflammatory dermatological disease associated with metabolic comorbidities, low quality of life and fatigue. Anaemia may cause fatigue, and it has been hypothesized that HS-related fatigue may be partly due to anaemia. Objective Our objective was to investigate a possible association between HS and anaemia. Methods We performed a hospital-based and population-based cross-sectional study investigating the red blood cell profile, i.e. haemoglobin. Results We identified a total of 32 hospital HS individuals, 430 population HS individuals and 20,780 population non- HS control individuals. The age-sex-smoking-adjusted analyses showed no differences in the haemoglobin level of the HS groups vs. the control group. Analyses of the anaemic subgroup of HS individuals revealed that 60% had normocytic anaemia and 40% microcytic anaemia, in concordance with anaemia of inflammation. Conclusion In contrast to our hypothesis, this study showed that HS is not associated with anaemia. Thus, anaemia may not be the cause of the described fatigue in HS patients. Furthermore, the results indicate that if an HS patient does suffer from anaemia it is most likely to be normocytic or microcytic and thus compatible with anaemia seen in other chronic inflammatory disorders. [ABSTRACT FROM AUTHOR]

Summary: Hidradenitis suppurativa (HS) is a chronic skin disease. It causes painful boils in specific body areas such as the armpits and the groins. This disease affects about 1% of people in the U.K. It is more common in women. HS causes pain, but few studies have looked at this aspect. Depression and anxiety affects how pain is experienced. The patient's age and sex can also influence the experience of pain. The authors aimed to study pain in patients with HS. They handed out questionnaires in a HS specialist clinic in Roskilde, Denmark (Oct 2017 – Mar 2018). Patients described their pain and difficulty of HS, and reported any symptom of depression and anxiety. Pain was described with different words. The most common words were 'shooting' (83%), 'itchy' (79%) and 'blinding' (75%). The study revealed that pain in HS relates to severity of HS and to symptoms of anxiety and depression. The authors found that the pain experience of HS patients can be divided into two different pain qualities: the so‐called nociceptive and neuropathic pain. These two pain types are usually treated with different medications: anti‐inflammatory drugs (e.g. aspirin) and antidepressants. In general, HS patients are more often depressed than other people. HS patients are likely to benefit from different pain relievers including both anti‐inflammatory drugs and antidepressants to treat their pain. However, more studies are needed to make definite recommendations on treatment of HS pain. This summary relates to the study: Pain perception in patients with hidradenitis suppurativa Linked Article: Nielsen et al. Br J Dermatol 2020; 182:166–174 [ABSTRACT FROM AUTHOR]