INTRODUCTION: Tuberous sclerosis complex is an autosomal dominant, rare, multisystemic disease with variable presentation. Involvement of the renal, cardiac, nervous, and dermatological systems is possible, manifested in 90% of patients. The diagnosis is conducted through clinical criteria, and genetic tests may be requested. CASE REPORT: The reported case is of a 13-year-old female patient, diagnosed ten years ago with tuberous sclerosis, manifesting diffusely distributed hypochromic spots and nail lesions on hands and feet. In addition, the patient reports the recent onset of hyperchromic lesions on the face accompanied by itching and bruising. CONCLUSION: Early identification of tuberous sclerosis complex is necessary to minimize the multisystemic repercussions in the patient’s life. [ABSTRACT FROM AUTHOR]