1. Developmentally regulated expression of persyn, a member of the synuclein family, in skin.
- Author
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Ninkina NN, Privalova EM, Pinõn LG, Davies AM, and Buchman VL
- Subjects
- Amino Acid Sequence, Animals, Epidermis metabolism, Mice, Molecular Sequence Data, Nerve Tissue Proteins analysis, Nerve Tissue Proteins chemistry, RNA, Messenger, Skin embryology, Synucleins, gamma-Synuclein, Gene Expression Regulation, Developmental, Neoplasm Proteins, Nerve Tissue Proteins genetics, Skin metabolism
- Abstract
Synucleins constitute a group of unique, evolutionarily conserved proteins that are expressed predominantly in neurons of the central and peripheral nervous system. Although the normal cellular functions of synucleins are not clear, these proteins have been implicated in various neurodegenerative conditions in humans. We found that persyn, a recently characterized member of the synuclein family, is expressed not only in the nervous system but also in the stratum granulosum of the epidermis of neonatal and adult mice. This finding together with our recent observations that persyn influences neurofilament network integrity in sensory neurons raises the possibility that persyn in skin could be involved in modulation of the keratin network., (Copyright 1999 Academic Press.)
- Published
- 1999
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