1. Singlet Oxygen Generation in Dark-Hypoxia by Catalytic Microenvironment-Tailored Nanoreactors for NIR-II Fluorescence-Monitored Chemodynamic Therapy.
- Author
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Chen T, Hou P, Zhang Y, Ao R, Su L, Jiang Y, Zhang Y, Cai H, Wang J, Chen Q, Song J, Lin L, Yang H, and Chen X
- Subjects
- Catalysis, Humans, Infrared Rays, Tumor Hypoxia, Tumor Microenvironment, Fluorescence, Molybdenum chemistry, Nanoparticles chemistry, Photochemotherapy, Singlet Oxygen chemistry
- Abstract
Singlet oxygen (
1 O2 ) has a potent anticancer effect, but photosensitized generation of1 O2 is inhibited by tumor hypoxia and limited light penetration depth. Despite the potential of chemodynamic therapy (CDT) to circumvent these issues by exploration of1 O2 -producing catalysts, engineering efficient CDT agents is still a formidable challenge since most catalysts require specific pH to function and become inactivated upon chelation by glutathione (GSH). Herein, we present a catalytic microenvironment-tailored nanoreactor (CMTN), constructed by encapsulating MoO4 2- catalyst and alkaline sodium carbonate within liposomes, which offers a favorable pH condition for MoO4 2- -catalyzed generation of1 O2 from H2 O2 and protects MoO4 2- from GSH chelation owing to the impermeability of liposomal lipid membrane to ions and GSH. H2 O2 and1 O2 can freely cross the liposomal membrane, allowing CMTN with a built-in NIR-II ratiometric fluorescent1 O2 sensor to achieve monitored tumor CDT., (© 2021 Wiley-VCH GmbH.)- Published
- 2021
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