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Seham Elhawary,1 Hala EL-Hefnawy,1 Fatma Alzahraa Mokhtar,1 Mansour Sobeh,2 Eman Mostafa,3 Samir Osman,4,* Mohamed El-Raey5,* 1Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt; 2Agro-BioSciences Research Division, Mohammed VI Polytechnic University, Ben-Guerir 43150, Morocco; 3Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6 October City, Giza, Egypt; 4Department of Pharmacognosy, Faculty of Pharmacy, Oct. 6 University, Giza, Egypt; 5Phytochemistry and Plant Systematic Department, National Research Centre, Dokki, Cairo, Egypt*These authors contributed equally to this workCorrespondence: Fatma Alzahraa MokhtarDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 12412, EgyptTel +201113154863Email drfatmaalzahraa1950@gmail.comIntroduction: Jasminum officinale L. is a very important medicinal and industrial flowering aromatic plant.Methods: The present study deals with Jasminum officinale L. leaves extract (JOLE) as a reducing and capping agent for the synthesis of silver nanoparticles (AgNPs) by the green pathway. Phenolic profile of the extract was evaluated using HPLC-PDA/MS/MS technique. Jasminum officinale L. leaves extract silver nanoparticles (JOLE-AgNPs) were characterized by ultraviolet light (UV), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), zeta potential and X-ray diffraction (XRD). JOLE-AgNPs were examined for their cytotoxic activities by neutral red uptake assay (NRU) against bladder (5637) and breast cancer (MCF-7) cell lines.Results: HPLC-PDA/MS/MS tentatively identified 51 compounds of different chemical classes. UV spectra showed absorption peak at λmax = 363 nm. The biosynthesized AgNPs were predominantly spherical in shape with an average size of 9.22 nm by TEM. The face cubic center (fcc) nature of silver nanoparticles was proved by XRD diffractogram. JOLE-AgNPs exhibited high cytotoxic activity against 5637 and MCF-7 cell lines compared to the cytotoxic activities of JOLE with IC50 of 13.09 μg/mL and 9.3 μg/mL, respectively.Discussion: The silver nanoparticles formed by Jasminum officinale L. showed high cytotoxic activities against MCF-7 and 5637 cell lines and can be introduced as a new alternative cytotoxic medication.Keywords: silver nanoparticles, HPLC-PDA/MS/MS, cytotoxic, Jasminum, bladder cancer, breast cancer

Elhawary S, EL-Hefnawy H, Alzahraa FA, et al. Int J Nanomedicine. 2020;15:9771–9781. The Editor and Publisher of International Journal of Nanomedicine wish to retract the published article. Concerns were raised regarding the alleged manipulation of data shown in Figure 6, where sections of the X-ray diffraction pattern appear to have been duplicated. The authors responded to our queries but were unable to provide an adequate explanation for the duplicated pattern nor could they provide the original files or data concerning this part of the study. As the authors were unable to verify the findings from their study the Editor requested for the article to be retracted and the authors were notified of this decision. Our decision-making was informed by our policy on publishing ethics and integrity and the COPE guidelines on retraction. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”. This retraction relates to this paper