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Stimulating effect of 1-ethoxysilatrane on healing processes of experimental stomach ulcers was studied in rats. 1-ethoxysilatrane inhibited lipid peroxidation in blood and stomach wall tissues, interacted with artificial membranes, and affected the rate of mitochondrial respiration in liver. A hypothesis is put forward on the membranotropic effect of 1-ethoxysilatrane which underlies its ulcerostatic effect.

Stimulatory effect of metalloatrans on the development of stomach wall connective tissue components was examined in rats with experimental acetate ulcer. Metalloatrans were shown to inhibit peroxide oxidation processes of lipids in blood and stomach tissue.

A stimulating effect of methylethyl(silatrane-I-ilmethyl)-sulphonium iodides, 1-(ethoxy)silatranes and 1-(chloromethyl)silatrane on the processes of rat test acetate ulcer healing is studied. Silatranes efficiency is not inferior to oxyferriscorbone and exceeds that of methacil. It is shown that all preparations inhibit the processes of lipids peroxidation in the blood, in liposomes and stomach tissue.

Neurophysiological effects of different metal derivatives of atranes at single and repeated introduction into rats have been studied. Spontaneous activity of separate hypothalamic neurons was found to change at introduction of atranes. Discharge activity of hypothalamic [correction of pretubercular] cells changed both in phasic and in tonic mode in response to single injection of atranes. The data obtained allow to conclude that metal derivatives of atranes do not exert specific effect on hypothalamic neurons.

Stimulating effect of I-ethoxy silatrane on healing of acetate derived stomach ulcer was studied in rats. The drug was shown to inhibit lipid peroxidation and free-radical oxidation in blood and gastric tissues as well as to accelerate reparation in ulcerous zone. I-Ethoxy silatrane interacted with artificial membranes and affected the respiration rate in liver mitochondria. Membranetropic effect of I-ethoxy silatrane appears to be involved in the drug ulcerostatic effect.

The ulcerostatic activity of methylethyl (sylathrane-1-ilmethyl) sulfoiodide, 1-(chlormethyl) sylatrane, and 1-(isopropoxy)hermatrane has been revealed at experimental acetate ulcer in rats. The effect of atranes was equal to that of oxyferriscorbone and exceeded that of methyluracil. All the compounds studied inhibited peroxide oxidation of lipids in blood and stomach tissues from ulcer and in model experiments in egg yolk liposomes. The processes of ulcer development and photodynamic effects of lipid peroxidation in biological objects have been summarized. The data obtained allow to conclude that the ulcerostatic mechanism of action effect of atranes and the comparable drugs is based on their antioxidative effect.

It has been demonstrated in rats with experimental gastric ulcer that 1-(chloromethyl) silatrane intensifies the development of granulation-fibrous tissue and favours optimization of the ratio of collagens and glycosaminoglycans, the main connective tissue biopolymers. Furthermore, 1-(chloromethyl) silatrane produces a more pronounced effect on hexosamine-containing glycoproteins in the ulcer tissue as compared with methyluracil and oxyferriscorbon. At the same time, judging by the time course of sialoproteins, the antiulcerous drugs, methyluracil and oxyferriscorbon, are much more effective antiinflammatory agents than 1-(chloromethyl)silatrane.

In the experiments on rabbits with experimental atherosclerosis the authors revealed lipolytic and antisclerotic effect of the above drug. It was also observed that it also possessed anticoagulation activity.

The sensitivity of the method of neutron scattering to novel neutron-nucleon interactions is analyzed. Upper limits on the coupling constant of such interactions are imposed using the available data on neutron powder diffraction on polycrystalline silicon. For the forces acting at ranges of < 10-11 m, these upper limits are already competitive with the best existing constraints on their coupling constant. A dedicated experiment can help improve the sensitivity to this coupling constant by nearly two orders of magnitude. [ABSTRACT FROM AUTHOR]

New results on the energy dependence of the total cross section (σ[sub R]) for [sup 6]He scattering on [sup 28]Si in the incident energy range 10-28 MeV/A are obtained. The α-particle-production cross sections for the [sup 28]Si([sup 6]He, [sup 4]He)X channel are measured as well. The secondary beam of [sup 6]He with an intensity of up to 5 x 10[sup 4] particle/s was generated by bombarding a thick beryllium target with ∼32-MeV/A [sup 7]Li ions. In the energy region below 17 MeV/A, σ[sub R] increases sharply. The experimental dependences of the total cross sections are compared with the results of σ[sub R] calculations using the double-folding potential within the optical model. The energy dependence of σ[sub R] for [sup 6]He differs from that for the neighboring nuclei, which can be associated with the structural features of the former nucleus. The energy spectra of α particles produced in the [sup 6]He interactions with silicon indicate two mechanisms of their production: transfer reaction and [sup 6]He breakup in the field of the [sup 28]Si nucleus. [ABSTRACT FROM AUTHOR]