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In the era of digitalization and artificial intelligence (AI), the utilization of Metaverse technology has become increasingly crucial. As the world becomes more digitized, there is a pressing need to effectively transfer real-world assets into the digital realm and establish meaningful relationships between them. However, existing approaches have shown significant limitations in achieving this goal comprehensively. To address this, this research introduces an innovative methodology called the Meta-Metaverse, which aims to enhance the immersive experience and create realistic digital twins across various domains such as biology, genetics, economy, medicine, environment, gaming, digital twins, Internet of Things, artificial intelligence, machine learning, psychology, supply chain, social networking, smart manufacturing, and politics. The multi-layered structure of Metaverse platforms and digital twins allows for greater flexibility and scalability, offering valuable insights into the potential impact of advancing science, technology, and the internet. This article presents a detailed description of the proposed methodology and its applications, highlighting its potential to transform scientific research and inspire groundbreaking ideas in science, medicine, and technology. [ABSTRACT FROM AUTHOR]

Advanced mathematical and deep learning (DL) algorithms have recently played a crucial role in diagnosing medical parameters and diseases. One of these areas that need to be more focused on is dentistry. This is why creating digital twins of dental issues in the metaverse is a practical and effective technique to benefit from the immersive characteristics of this technology and adapt the real world of dentistry to the virtual world. These technologies can create virtual facilities and environments for patients, physicians, and researchers to access a variety of medical services. Experiencing an immersive interaction between doctors and patients can be another considerable advantage of these technologies, which can dramatically improve the efficiency of the healthcare system. In addition, offering these amenities through a blockchain system enhances reliability, safety, openness, and the ability to trace data exchange. It also brings about cost savings through improved efficiencies. In this paper, a digital twin of cervical vertebral maturation (CVM), which is a critical factor in a wide range of dental surgery, within a blockchain-based metaverse platform is designed and implemented. A DL method has been used to create an automated diagnosis process for the upcoming CVM images in the proposed platform. This method includes MobileNetV2, a mobile architecture that improves the performance of mobile models in multiple tasks and benchmarks. The proposed technique of digital twinning is simple, fast, and suitable for physicians and medical specialists, as well as for adapting to the Internet of Medical Things (IoMT) due to its low latency and computing costs. One of the important contributions of the current study is to use of DL-based computer vision as a real-time measurement method so that the proposed digital twin does not require additional sensors. Furthermore, a comprehensive conceptual framework for creating digital twins of CVM based on MobileNetV2 within a blockchain ecosystem has been designed and implemented, showing the applicability and suitability of the introduced approach. The high performance of the proposed model on a collected small dataset demonstrates that low-cost deep learning can be used for diagnosis, anomaly detection, better design, and many more applications of the upcoming digital representations. In addition, this study shows how digital twins can be performed and developed for dental issues with the lowest hardware infrastructures, reducing the costs of diagnosis and treatment for patients. [ABSTRACT FROM AUTHOR]

Medical digital twins, which represent medical assets, play a crucial role in connecting the physical world to the metaverse, enabling patients to access virtual medical services and experience immersive interactions with the real world. One serious disease that can be diagnosed and treated using this technology is cancer. However, the digitalization of such diseases for use in the metaverse is a highly complex process. To address this, this study aims to use machine learning (ML) techniques to create real-time and reliable digital twins of cancer for diagnostic and therapeutic purposes. The study focuses on four classical ML techniques that are simple and fast for medical specialists without extensive Artificial Intelligence (AI) knowledge, and meet the requirements of the Internet of Medical Things (IoMT) in terms of latency and cost. The case study focuses on breast cancer (BC), the second most prevalent form of cancer worldwide. The study also presents a comprehensive conceptual framework to illustrate the process of creating digital twins of cancer, and demonstrates the feasibility and reliability of these digital twins in monitoring, diagnosing, and predicting medical parameters. [ABSTRACT FROM AUTHOR]

Preparing the infrastructure for analyzing, recognizing, and characterizing microorganisms in the Metaverse can transform the fields of biology, medicine, and drug discovery. Accordingly, the realization of digital twins of microorganisms, such as viruses, fungi, algae, bacteria, protozoa, archaea, and multicellular animal parasites, can streamline the applicability of the Metaverse and similar emerging technologies like Cyber-Physical Healthcare Systems (CPHS). This is why a new approach to the digital twinning of bacteria has been presented in this research. This method of digital twinning can revolutionize the research and study of bacteria because it allows us to separate useful and harmful bacterial species, increasing the efficiency of treatment noticeably. This innovative method can easily be used by clinics, medical centers, or even by private users physically and virtually and can be adapted to every centralized or decentralized Metaverse Platform. To determine the proper treatment, biologists have always tried to identify the correct bacterial species that prompted a bacterial infection. They use various indicators, such as the bacterial cell's shape and the size of the colony formed by the bacteria, to classify different types of bacteria with different biochemistries and shapes. However, it is challenging because of the extensive similarities between some species. For instance, such similarities exist between Staphylococcus aureus and Staphylococcus saprophyticus, which has caused numerous false diagnostic reports by operators. Wrong species reports bring about treatment failure and increase antibiotic resistance issues. Therefore, the digital twins of bacteria cover all of their identifiable characteristics and overcome many limitations to study them. In this approach, DTL techniques, including MobileNetV2, EfficientNetV2-S, and ResNet-50, have been employed to build digital twins of bacteria species. A hybrid dataset was used for training and evaluation. Among the models, EfficientNetV2-S exhibited the best performance, with a validation accuracy of 99.58% and a test accuracy of 99.33%. The results showed the ability of deep learning models to make bacteria digital twins based on image processing from different labs, thus assisting experts in speeding up the process and reducing diagnostic errors. In addition, in the mispredicted cases, the correct species was among the first three choices of the model. Therefore, not only can experts use DTL approaches to speed up the digital twin realization of microorganisms in the Metaverse, but they can also use these methods to reduce diagnostic errors. • Introducing a technique to streamline digital twinning of microorganisms using CNN. • Describing machine learning digital twins of microorganisms in the Metaverse. • Presenting an exact, economical digital twinning approach via smartphone photography. • Providing a comprehensive bacteria species dataset for future method development. [ABSTRACT FROM AUTHOR]