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Transcranial magnetic stimulation (TMS) is a research tool that has potential to provide new insights into strength training-induced adaptations. However, using TMS to study the lower limbs is challenging, and sex-specific reliability has yet to be reported. We examined the reliability of corticospinal excitability and silent periods for the rectus femoris, vastus lateralis, and biceps femoris in both sexes. Thirteen males and 14 females reported to the laboratory twice. During both trials, a double cone coil was used to deliver 20 pulses to the rectus femoris hotspot with a stimulator output of 130% of active motor threshold. Motor-evoked potential peak-to-peak amplitude, which reflects corticospinal excitability, and silent period duration were quantified. Our results offer 4 novel findings. First, corticospinal excitability and silent period demonstrated higher reliability for the females. Second, regardless of sex and muscle, the silent period was more reliable than corticospinal excitability. Third, reliability was highest for our target muscle (rectus femoris), with lower reliability for the vastus lateralis and biceps femoris, suggesting that these methods cannot be used to study coactivation. Fourth, active motor threshold showed less variability than corticospinal excitability and silent period but increased at trial 2 in females. Many of the intraclass correlation coefficients were excellent ($0.90), although we attribute this finding to variability between subjects. Reliability of lower-limb TMS measures may be sex, muscle, and variable dependent. Our findings suggest that both males and females should be included in lower-limb TMS research, although combining data between sexes should be approached cautiously. [ABSTRACT FROM AUTHOR]

Carr, JC and Ye, X. Strength and electromyographic responses of upper and lower limbs during maximal intermittent contractions in males and females. J Strength Cond Res 36(9): 2403–2409, 2022—This study examined the strength and electromyographic (EMG) responses of upper vs. lower limb muscles during intermittent maximal contractions in both sexes. Twenty subjects (n = 7 women) performed a fatiguing protocol (6, 30-second intermittent maximal isometric contractions with a 50% duty cycle) with either the elbow flexors or the knee extensors on separate visits. Bipolar surface EMG signals were detected from the biceps brachii and vastus lateralis muscles (n = 5 women retained). Women maintained more of their maximal force than men (Δforce: men vs. women = −55.0 ± 12.8% vs. −43.3 ± 9.9%, p = 0.042). Although force loss was similar between the elbow flexors and knee extensors, the EMG responses showed greater reductions for the biceps brachii than those for the vastus lateralis (Δamplitude: biceps brachii vs. vastus lateralis: −32.0 ± 22.3% vs. −18.9 ± 28.9%; Δmedian frequency: biceps brachii vs. vastus lateralis: −31.1 ± 14.5% vs. −10.3 ± 17.0%). During a series of maximal intermittent isometric contractions with 30 seconds of recovery between work bouts, women are more fatigue resistant than men. In addition, the greater electrophysiological fatigue exhibited by the biceps brachii than that by the vastus lateralis suggests that high-intensity contractions involving elbow flexion will have a greater rate of fatigue progression than those involving knee extension. [ABSTRACT FROM AUTHOR]

The time‐of‐day influence on neuromuscular function is well‐documented, but important details remain elusive. It is currently unknown whether males and females differ in their diurnal variation for optimal neuromuscular performance. The purpose of this study is to identify the time‐of‐day influence on neuromuscular function between sexes and determine whether these responses differ for the upper versus lower limbs. A group of males (n = 12) and females (n = 15) completed neuromuscular performance testing in the morning (07:00–09:00) and evening (17:00–19:00) on separate days in a randomized order. Maximal force, the normalized rate of force development, EMG, normalized EMG rise, and submaximal force steadiness were compared between morning and evening hours. The main findings show that maximal force was greater in the evening for the knee extensors (d = 0.570, p < 0.01) but not the elbow flexors (d = 0.212, p = 0.281), whereas maximal muscle excitation was greater in the evening for the biceps brachii (d = 0.348, p < 0.01) but not the vastus lateralis (d = 0.075, p = 0.526) with no influence of sex. However, force steadiness during knee extension was superior in the evening versus the morning for males (d = 0.734, p = 0.025) and compared to evening values for females (g = 1.19, p = 0.032). Overall, these findings show that time‐of‐day affects the knee extensors more than the elbow flexors and that diurnal variability between sexes appears to be task‐dependent. [ABSTRACT FROM AUTHOR]

The purpose of this experiment was to evaluate the bilateral index in force and electromyographic (EMG) responses for the dominant and non-dominant hands during maximal handgrip contractions in males and females. Thirty-two right-handed participants (16 females) performed maximal unilateral and bilateral handgrip contractions on two separate visits. Bilateral indices were computed for maximal force, rate of force development (RFD100), EMG amplitude, and the rate of EMG rise (RER). There was a bilateral deficit for maximal force in the dominant (−4.98 ± 7.39%, p < 0.001; d = 0.674) but not the non-dominant hand (−1.57 ± 9.10%, p = 0.334; d = 0.173). No deficits were observed for rapid force. The non-dominant flexor carpi radialis showed a bilateral facilitation in EMG amplitude (+12.32 ± 19.29%, p < 0.001; d = 0.638), yet a bilateral deficit for RER (−22.10 ± 27.80%, p < 0.001; d = 0.795). No sex differences were observed for any of the bilateral indices. These data suggest that maximal but not rapid force is susceptible to a bilateral deficit during contractions of the hands. The EMG responses did not parallel the force data. We show sex does not influence the magnitude or direction of the bilateral index in this muscle group. [ABSTRACT FROM AUTHOR]

• The study examines the force fluctuations during maximal handgrip using detrended fluctuation analysis to measure force complexity. • The influence of fatigue and sex on force complexity during handgrip is assessed. • The findings show that females exhibit greater force complexity than males during maximal handgrip. • During repetitive maximal handgrip contractions, force complexity is diminished to a greater extent for females compared to males. • This study demonstrates the utility of nonlinear methods to identify sex differences in motor control strategies. This work examines the temporal structure of force fluctuations during maximal handgrip with detrended fluctuation analysis (DFA α). Here, we assess the influence of fatigue and sex on force complexity during unimanual handgrip for the fatigued and the contralateral, non-fatigued hand. Participants randomly completed experimental sessions requiring fatiguing handgrip contractions or control measurements only. Maximal unimanual forces of both hands were measured before and after the fatigue trial or a time-matched control visit. DFA revealed substantially lower alpha values for females (PRE = 1.15, POST = 1.25) compared to males (PRE = 1.30, POST = 1.33) regardless of fatigue (p < 0.01, d = 0.738) for the dominant hand with a similar pattern observed for the contralateral, non-fatigued hand (p = 0.045, d = 0.561). Females also showed greater alpha changes (Δ = 0.09) versus males (Δ = 0.01) following fatigue (p = 0.028, η p 2 = 0.151). The data provide evidence of reduced force complexity during successive maximal handgrip contractions for females, but not males. Our findings highlight task-specific factors involving force control and demonstrate the utility of complexity analyses to provide insights regarding the influence of sex on motor control strategies. [ABSTRACT FROM AUTHOR]