12 results on '"De Giorgio, F."'
Search Results
2. ABANDON THE TERM 'SECOND VICTIM' Everyone is affected, everyone a victim
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Vetrugno, Giuseppe, De-Giorgio, F., and Foti, F.
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N/A ,Settore MED/43 - MEDICINA LEGALE - Published
- 2019
3. SENSORS ON HOSPITAL BEDS AND CHAIRS Costs of hospital bed and chair sensors include the time of healthcare workers monitoring them
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Vetrugno, Giuseppe, Spagnolo, Antonio Gioacchino, and De-Giorgio, F
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N/A ,Settore MED/43 - MEDICINA LEGALE - Published
- 2018
4. Haemophagocytic syndrome associated with mucormycosis infection
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Arena, V., De-Giorgio, F., Pennacchia, I., Raffaele Manna, Vetrugno, G., Stigliano, E., Milic, N., Gasbarrini, G., and Abenavoli, L.
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Adult ,Male ,medicine.medical_specialty ,Pathology ,Biopsy ,Immunology ,Hemophagocytic ,Autopsy ,Disease ,Lymphohistiocytosis, Hemophagocytic ,Malignant lymphoma ,Fatal Outcome ,Predictive Value of Tests ,medicine ,Immunology and Allergy ,Humans ,Mucormycosis ,Immunodeficiency ,Pharmacology ,Lymphohistiocytosis ,medicine.diagnostic_test ,Haemophagocytic syndrome ,business.industry ,Settore MED/09 - MEDICINA INTERNA ,Bone Marrow Examination ,Settore MED/43 - MEDICINA LEGALE ,medicine.disease ,Dermatology ,Bone marrow examination ,Treatment Outcome ,Liver ,Renal transplant ,Gastric Mucosa ,mucormycosis infection ,business ,Immunosuppressive Agents - Abstract
Several clinical forms of mucormycosis are recognized. The tendency of mucoraceous zygomycetes to invade the blood vessels often produces a disseminated infection. A case of a disseminated mucormycosis complicated by a haemophagocytic syndrome (HS) in a 32-year-old Caucasian male is reported in this article. Few cases of infection-associated HS (IAHS), involving infections caused by fungi, have been reported. In all the recorded cases, the fungal infection coexists with malignant lymphoma, immunodeficiency and a long-term steroid therapy for renal transplant or Crohn's disease. This is the second described case of the HS due to mucormycosis.
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- 2012
5. Two Cases of Acute Propane⁄Butane Poisoning in Prison
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Rossi, Riccardo, Suadoni, F, Pieroni, L, De Giorgio, F, and Lancia, M.
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propane ,butane ,prison ,Settore MED/43 - MEDICINA LEGALE ,suicide - Published
- 2012
6. A case of suicidal suffocation simulating homicide
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d(')Aloja, E., De Giorgio, F., Ausania, F., and Cascini, F.
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Suicide ,autopsy ,autoerotic ,forensic science ,homicide ,suffocation ,plastic bag ,asphyxia ,Settore MED/43 - MEDICINA LEGALE ,elderly ,forensic autopsy - Published
- 2011
7. Shaken-baby syndrome: a challenging diagnosis
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De Giorgio F, De Mercurio D, Giuseppe VETRUGNO, and Abbate A
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shaken baby syndrome ,Settore MED/43 - MEDICINA LEGALE - Published
- 2005
8. Phenotypic effects of chronic and acute use of methiopropamine in a mouse model
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Federica Foti, Fabio De-Giorgio, Bruna Cerbelli, Andrea Ossato, Sabrine Bilel, Francesco Botrè, Eugenio Sangiorgi, Matteo Marti, Alfonso Baldi, Foti, F, Marti, M, Ossato, A, Bilel, S, Sangiorgi, E, Botrè, F, Cerbelli, B, Baldi, A, and De-Giorgio, F
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Male ,0301 basic medicine ,Ischemia ,Physiology ,Socio-culturale ,Thiophenes ,Kidney ,Sudden death ,Methamphetamine ,Pathology and Forensic Medicine ,Death, Sudden ,03 medical and health sciences ,chemistry.chemical_compound ,Mice ,0302 clinical medicine ,Gastrointestinal tract ,Heart Rate ,Methiopropamine ,Novel psychoactive substances ,kidney ,methiopropamine ,mice ,myocardium ,novel psychoactive substances ,animals ,death, sudden ,heart rate ,intestines ,ischemia ,male ,methamphetamine ,mice, inbred ICR ,models, animal ,psychotropic drugs ,street drugs ,thiophenes ,vasoconstriction ,Heart rate ,medicine ,Animals ,Myocardium ,Mice, Inbred ICR ,Psychotropic Drugs ,Illicit Drugs ,business.industry ,Novel psychoactive substance ,Settore MED/43 - MEDICINA LEGALE ,Thermoregulation ,medicine.disease ,Intestines ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Vasoconstriction ,Models, Animal ,medicine.symptom ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Methiopropamine (MPA) is a structural analogue of methamphetamine and belongs to the category of the novel psychoactive substances. To the best of our knowledge, no experimental study has been performed to evaluate the organ damage evoked by MPA administration in an animal model. Therefore, the main purpose of the present study was to investigate the histological changes in CD-1 male mice following the chronic administration of MPA. MPA-chronically treated mice showed myocardial damage with features consistent with repeated episodes of ischemia and a pattern of kidney damage and gastrointestinal ischemia, with ischemic-necrotic lesions of variable extent. In agreement with the analogies between MPA and methamphetamine, we link organ damage secondary to MPA administration to the vasoconstrictive effect exhibited by both compounds. Chronically MPA-treated mice did not show changes in body weight, food intake, thermoregulation, muscular strength and motor coordination in the accelerod test. However, acute MPA administration significantly increased their heart rate and promoted vasoconstriction, which were associated with the sudden death of a subset of animals (40% of all chronically treated mice). In conclusion, the present study demonstrates that MPA consumption could induce health hazards, highlighting the risk of sudden catastrophic events; therefore, clinicians should be aware of these data and consider MPA screening when no other drug is identified by a urine drug screen.
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- 2018
9. Formation of the inflammasome in acute myocarditis
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Harsha Kannan, Marco Anzini, Gianfranco Sinagra, Chiara Sonnino, Rossana Bussani, Eleonora Mezzaroma, Fabio De-Giorgio, Furio Silvestri, Alfonso Baldi, Marco Merlo, Antonio Abbate, Stefano Toldo, Benjamin W. Van Tassell, Toldo, S, Kannan, H, Bussani, Rossana, Anzini, M, Sonnino, C, Sinagra, Gianfranco, Merlo, M, Mezzaroma, E, De Giorgio, F, Silvestri, Furio, Van Tassell, Bw, Baldi, A, Abbate, A., Bussani, R, Sinagra, G, Silvestri, F, and Baldi, Alfonso
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Myocarditis ,Inflammasomes ,Cardiomyopathy ,Myocarditi ,Heart failure ,Autopsy ,Inflammasome ,Interquartile range ,Humans ,Medicine ,biology ,business.industry ,Pyroptosis ,Settore MED/43 - MEDICINA LEGALE ,Middle Aged ,medicine.disease ,Toxic injury ,Acute Disease ,Immunology ,biology.protein ,Female ,Inflammation Mediators ,Antibody ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Acutemyocarditisisanin flammatorydisorderoftheheartmuscleinwhichtheseverityofinjurydependsbothonthenatureoftheoffendingagent(i.e.virus)andontheensuinginflammatoryresponse.Thede fini-tion excludes, however, the response to ischemic or toxic injury. Theheart, however, like other organs, may provide a stereotyped responsetoinjury.Followingischemicinjury,theformationoftheinfl ammasomein the heart promotes heart failure [1].Theinflammasome is a macro-molecular structure activated during injury that amplifies the responseby processing Interleukin-1β (IL-1β) and IL-18, and promotion of celldeath [2]. Viral infections may lead to either death of the virus and thecell (pyroptosis), or survival of both cell and virus with persistence ofthe infection through inhibition of the inflammasome (evasion) [3].Therearenoreportsoftheinflammasomeinacutemyocarditis.Wehy-pothesize that the viral infection or the ensuing cellular destructionleads to the formation of the inflammasome, providing an opportunityto explore inflammasome-related markers for diagnostic or prognosticpurposes. Furthermore at present day, there are no specific treatmentsfor acute myocarditis, and thus inhibitors of the inflammasome couldrepresent a new therapeutic approach.We studied samples obtainedthrough endomyocardialbiopsy in11patients with acute lymphocytic myocarditis (b4 weeks of symptomsonset) in Trieste, Italy. The diagnosis was based upon pathology exam-ination and clinical scenario (Table 1). As a comparison group westudied autopsy samples of 11 patients with acute myocarditis diag-nosed post mortem, and 5 control subjects who had died withoutacute myocarditis or other acute cardiac conditions.Weemployedimmunofluorescencestainingtodetectin flammasomeaggregatesusingantibodiesraisedagainstthescaffoldprotein,ApoptosisSpeck-like protein containing a caspase-1 recruiting domain (ASC), and/or the effector protein, caspase-1, as previously described [1].Tocharac-terizethetypeofcell,weusedadoublestainingtechniquewithantibod-ies against cardiac actin to identify cardiomyocytes, S100A4 to identifyfibroblasts, andCD31 forendothelialcells. To overcomefor the auto fluo-rescence of sarcomeric proteins, we used a solution of 1% Sudan black in70% ethanol for 5 min. Images of samples were acquired with an IX70microscope and cellSens Dimension di gital imaging software (Olympus,Central Valley, PA) using a 40× objective (400× magnification). Filtersets for each separate fluorescence-conjugated antibody were layeredtorenderacompositeimage.Theinflammasome “specks” were countedby cell type (cardiomyocyte, leukocytes, fibroblasts and endothelialcells) per high power field of view (40×). Data are presented as medianand interquartile range and non-parametric Mann–Whitney test wasused.Intracellularaggregates of ASC and/ or caspase-1 indicative of the for-mation of the inflammasome were seen in leukocytes, cardiomyocytes,fibroblasts and endothelial cells in heart biopsy samples of all 11 cases(100%), and in heart samples of 10 of 11 post-mortem cases (91%), andin none of the controls (0%, P b 0.002)(Fig. 1). ASC aggregates co-localized with caspase-1 aggregates in virtually all cases. The numberof inflammasomes was variable across cases ranging between 3 and 14specks in biopsies, and between 0 and 45 specks per field in autopsies,without statistically significant differences (data not shown). Some
- Published
- 2014
10. Cardiac metastases
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R, Bussani, F, De-Giorgio, A, Abbate, F, Silvestri, Bussani, Rossana, DE GIORGIO, F, Abbate, A, and Silvestri, Furio
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Heart Neoplasms ,Cardiac Metastases ,Humans ,Review ,heart ,General Medicine ,Settore MED/43 - MEDICINA LEGALE ,Pericardium ,Pericardial Effusion ,Pathology and Forensic Medicine - Abstract
Tumours metastatic to the heart (cardiac metastases) are among the least known and highly debated issues in oncology, and few systematic studies are devoted to this topic. Although primary cardiac tumours are extremely uncommon (various postmortem studies report rates between 0.001% and 0.28%), secondary tumours are not, and at least in theory, the heart can be metastasised by any malignant neoplasm able to spread to distant sites. In general, cardiac metastases are considered to be rare; however, when sought for, the incidence seems to be not as low as expected, ranging from 2.3% and 18.3%. Although no malignant tumours are known that diffuse preferentially to the heart, some do involve the heart more often than others--for example, melanoma and mediastinal primary tumours. This paper attempts to review the pathophysiology of cardiac metastatic disease, epidemiology and clinical presentation of cardiac metastases, and pathological characterisation of the lesions.
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- 2007
11. Increased apoptosis in remote non-infarcted myocardium in multivessel coronary disease
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BIONDI ZOCCAI, Giuseppe, Antonio, Abbate, Fortunata, Vasaturo, Scarpa, Susanna, Daniele, Santini, Antonio Maria Leone, Parisi, O., Fabio De Giorgio, Rossana, Bussani, Furio, Silvestri, Feliciano, Baldi, Biasucci, Luigi M., Alfonso, Baldi, Santini, Daniele, BIONDI ZOCCAI, Gg, Abbate, A, Vasaturo, F, Scarpa, S, Santini, D, Leone, Am, Parisi, Q, DE GIORGIO, F, Bussani, Rossana, Silvestri, Furio, Baldi, F, Biasucci, Lm, Baldi, A., Bussani, R, Silvestri, F, and Baldi, Alfonso
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Male ,medicine.medical_specialty ,Myocardial ischemia ,Myocardial Infarction ,Ischemia ,non-infarcted myocardium ,Infarction ,Autopsy ,apoptosis ,coronary artery disease ,multivessel ,myocardial infarction ,myocardial ischemia ,remodeling ,coronary disease ,Coronary artery disease ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Myocardial infarction ,Artery occlusion ,Multivessel ,Ventricular Remodeling ,business.industry ,Vascular disease ,Apoptosi ,Settore MED/43 - MEDICINA LEGALE ,medicine.disease ,Coronary Vessels ,Immunohistochemistry ,Remodeling ,medicine.anatomical_structure ,cardiovascular system ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
Background: Multivessel coronary disease after myocardial infarction is a major risk factor for unfavorable cardiac remodeling and death due to pump failure, but underlying pathophysiologic mechanisms are still uncompletely established. Post-infarction myocardial apoptosis has been recently implicated as a cause of ongoing cell loss leading to cardiac failure. Our aim was to assess the role of post-infarction myocardial apoptosis and pro-apoptotic factor expression in the non-infarcted remote myocardium of subjects with multivessel coronary disease. Methods: Twenty-one males dying after recent myocardial infarction with permanent occlusion of the infarct-related artery were selected at autopsy. Apoptosis was assessed at viable myocardial regions remote from infarction by co-staining for in situ end-labeling of DNA fragmentation and cleaved caspase-3. Expression of pro-apoptotic factor bax and hypoxia-induced factor-1alpha was evaluated by immunohistochemistry. Results: Subjects with multivessel disease (N = 11) showed a significantly two-fold higher myocardial apoptosis in comparison to subjects with single vessel disease (N = 10) (0.9% vs. 0.5%, p = 0.013). Similarly, myocardial bax expression was increased in patients with multivessel disease (3.0% vs. 1.4%, p = 0.029). Stratification for the number of diseased coronary vessels confirmed the association between extent of coronary disease and apoptotic rates (p = 0.022). Even in subjects dying over 30 days after infarction multivessel disease remained predictive of enhanced myocardiocyte apoptosis at remote regions (p = 0.033). Conclusions: Post-infarction myocardial apoptosis and bax expression in remote left ventricular regions are significantly increased in male patients with multivessel coronary disease in comparison to those with isolated infarct-related artery occlusion. These findings suggest that apoptotic cell loss in the viable non-infarcted myocardium, possibly due ongoing ischemia, may play a relevant role in the unfavorable clinical course typical of multivessel disease after myocardial infarction. © 2004 Published by Elsevier Ireland Ltd.
- Published
- 2004
12. Infarct-related artery occlusion, tissue markers of ischemia, and increased apoptosis in the peri-infarct viable myocardium
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Giovanna Liuzzo, Antonio Abbate, Fortunata Vasaturo, Fabio De Giorgio, Gianfranco Sinagra, Daniele Santini, Susanna Scarpa, Rossana Bussani, George W. Vetrovec, Giuseppe Biondi-Zoccai, Furio Silvestri, Filippo Crea, Alfonso Baldi, Antonio Maria Leone, Feliciano Baldi, Anna Severino, Alessandro Petrolini, Luigi M. Biasucci, Abbate, A, Bussani, Rossana, BIONDI ZOCCAI, Gg, Santini, D, Petrolini, A, DE GIORGIO, F, Vasaturo, F, Scarpa, S, Severino, A, Liuzzo, G, Leone, Am, Baldi, F, Sinagra, Gianfranco, Silvestri, Furio, Vetrovec, Gw, Crea, F, Biasucci, Lm, Baldi, A., Bussani, R, Sinagra, G, Silvestri, F, and Baldi, Alfonso
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Male ,Pathology ,Heart disease ,Myocardial Ischemia ,Ischaemia ,infarct myocardium ,Occlusion ,Myocytes, Cardiac ,remodelling ,Myocardial infarction ,Aged, 80 and over ,TUNEL assay ,Ventricular Remodeling ,Caspase 3 ,apoptosis ,Immunohistochemistry ,medicine.anatomical_structure ,myocardial infarction ,Caspases ,Circulatory system ,Cardiology ,Female ,Autopsy ,Cardiology and Cardiovascular Medicine ,Artery ,medicine.medical_specialty ,Ischemia ,ischemia ,Internal medicine ,In Situ Nick-End Labeling ,medicine ,Humans ,Artery occlusion ,cardiovascular diseases ,cyclo-oxygenase-21 ,Aged ,business.industry ,Hypoxia-inducible factor-1 ,Coronary Stenosis ,Remodelling ,Apoptosi ,Settore MED/43 - MEDICINA LEGALE ,medicine.disease ,Actins ,hypoxia-inducible factor-1 ,Case-Control Studies ,Cyclo-oxygenase-2 ,business ,Biomarkers - Abstract
Aims: Unfavourable cardiac remodelling often complicates acute myocardial infarction (AMI) as a result of increased cardiomyocyte apoptosis. It is currently unclear whether ongoing or recurrent ischaemia is an independent determinant for increased apoptosis in peri-infarct viable myocardium. Methods and results: In order to assess the link between infarct-related artery (IRA) occlusion, ischaemia, and apoptosis, 30 subjects dying 7-120 days after AMI (16 with IRA occlusion and 14 with patent IRA) and five control subjects were selected at autopsy. Cardiomyocytes were defined as apoptotic if co-expressing TUNEL and activated caspase-3. Expression of both hypoxia-inducible factor-1 and cyclo-oxygenase-2 was assessed in the peri-infarct myocardium and considered as tissue markers of ischaemia. Evidence of ischaemia was significantly more frequent in cases with IRA occlusion (53%) than in cases with patent IRA (15%) or control hearts (0%, P = 0.026). The finding of IRA occlusion and markers of ischaemia identified cases with higher apoptotic rates (ARs) in the peri-infarct viable myocardium [12.2% (8.2-14.0), P < 0.001 vs. others], whereas IRA occlusion without ischaemia was associated with lower AR, not significantly different from patent IRA [3.0% (1.0-7.9) vs. 2.2% (1.0-5.8), respectively, P = 0.42] Conclusion: Ischaemia in the peri-infarct viable myocardium is present in over 50% of subjects dying late after AMI with IRA occlusion, and it is associated with increased apoptosis. Relief of ischaemia after AMI may prove of benefit in preventing apoptosis and its consequences. © The European Society of Cardiology 2005. All rights reserved.
- Published
- 2005
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