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Accurate staging of patients with Neuroblastoma is essential for prognosis and for determining the most appropriate treatment. The neoplastic involvement of regional lymph-nodes (l.n.) is an important prognostic feature; the surgical exploration of these L.n. is mandatory for localized neuroblastoma (NBL) (stage I and II) in wich surgery represent the main treatment. The Authors have carried out a retrospective analysis of the cases registered in Italy between 1985 and 1989

The purpose of this study is to evaluete the Italian experience about localized Fivrosarcomas (FS) and Neurogenic Darcomas (NS)

Lo studio si propone di valutare il ruolo dell'asportazione del tumore primitivo (TP) nei bambini in età inferiore all'anno con neuroblastoma stadio IVs

I tumori magli del fegato in età pediatrica sono rappresentati da due forme istologiche differenti: l'Epatoblastoma (EPB) e l'Epatocarcinoma (EPC). Gli Autori esaminano le caratteristiche cliniche, la stadiazione e gli aspetti terapeutici. Vengono altresì presentati i dati della letteratura ed i risultati del Protocollo Italiano di cura di queste neoplasie.

Gli Autori eseminano tutti gli aspetti del ruolo della chirurgia nel trattamento di queste neoplasie, valutandone le applicazioni per tipo di tumore, benigno o maligno, e per sede interessata.

Background and Objectives Fibrosarcoma is a rare soft tissue sarcoma (STS) that has two peaks of incidence in pediatric patients: one in infants and young childern (infantile fibrosarcoma), another in older children (“adult type” fibrosarcoma). The purpose of this study was to describe the clinical features and the treatment results in patients affected by fibrosarcoma enrolled in two consecutive studies run by the STS-Italian Cooperative Group (ICG) between 1979 and 1995. Patients and Methods Twenty-five evaluable patients were grouped according the intergroup rhabdomyosarcoma staging (IRS) system: 12 Gr I, 5 Gr II, 8 Gr III. The cut-off point between the two forms was considered the age of 2 years: 14 patients were affected by infantile and 11 by adult type of fibrosarcoma. The therapeutic guidelines were not strict and not different for the two forms: patients with initial macroscopic excision (Gr I–II) were given IVA or VAC; Gr III had VAC or VAIA and subsequent excision, if feasible. Radiation therapy (RT) was delivered in patients > 3 years with microscopic (42 Gy) and macroscopic (54 Gy) residuals. Results Thirteen patients are alive without evidence of disease: 10 in first complete remission (CR), 7 Gr I, 1 Gr II, 2 Gr III, 3 in second CR after local relapse (LR) (2 Gr I, 1 Gr II). Two Gr I patients are alive with metastatic relapse. Nine patients died: six of progressive disease (PD) (three Gr II, three Gr III), two because of a second tumor (one Gr I, one Gr III) and one because of other causes (Gr III). One Gr III patient was lost at follow up, 2 years from diagnosis. The 10 years overall survival (OS) is 67.4% and the progression-free survival (PFS) is 52.2%. The OS for patients 2 years (5 of 11). Conclusions The complete excision at diagnosis was the treatment of choice and was related to the best outcome. Microscopical residuals were difficult to treat with chemo-radiotherapy in both forms of fibrosarcoma. Neoadjuvant chemotherapy (CT) obtained a partial remission (PR) only in three of eight cases, while no conclusions concerning the efficacy of CT for infantile forms are possible. Patients

To determine whether resection of primary tumor has a favorable influence on outcome of infants (age 0 to 11 months) with IV-s Neuroblastoma.

Dalla revisione della casistica del gruppo di Studio Italiano sui Tumori epatici del Bambino (GSTEB), risulta un miglioramento dell'Outcome di questi pazienti. Gli Autori presentano i risultati dello Studio.

Nella casistica del Gruppo Cooperativo Italiano per il Neuroblastoma sono racolti dal 1976 al 1992 91 casi di NBstadio IV-s. Viene analizzata l'influenza della chirurgia del tumore primitivo sull'outcome di questi pazienti.

Only complete resection can give hope for cure to children affected by hepatic malignancies.. The study evaluate the question: Surgical resection D'Emblèe or after Primary Chemotherapy?

The Authors analyze the preliminary results of the first Italian Cooperative Research program on childhood malignant epithelial liver tumors. The value of radical surgery and the effectiveness of cisplatin and adriamycin in inducing tumor response are undelined.