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4 results on '"Akubue PI"'

1. The effect of tetrodotoxin on the 5-hydroxytryptamine induced responses of the guinea-pig isolated gastrointestinal preparations.

Author

Akubue PI

Subjects
Acetylcholine pharmacology, Animals, Cecum drug effects, Colon drug effects, Drug Interactions, Esophagus drug effects, Female, Guinea Pigs, In Vitro Techniques, Intestine, Small drug effects, Male, Nicotine pharmacology, Stomach drug effects, Muscle Contraction drug effects, Muscle, Smooth drug effects, Serotonin pharmacology, Tetrodotoxin pharmacology
Abstract

Tetrodotoxin was used to investigate the site of action of 5-hydroxytryptamine on various longitudinal muscle preparations from the guinea-pig gastrointestinal tract. It was found that the contractile effect of 5-hydroxytryptamine on the oesophagus, the terminal ileum, the taenia caeci and the proximal colon was partly indirect through the activation of cholinergic fibres and partly direct on the smooth muscle. However on the stomach strip, the duodenum, the mid-intestine, the mid and terminal colons, the action is completely indirect through the stimulation of cholinergic nerves.

Published
1977

2. An analysis of the action of drugs on the circular muscle strips from the caecum of the guinea-pig.

Author

Akubue PI

Subjects
Animals, Cecum drug effects, Cold Temperature, Drug Synergism, Ganglia drug effects, Guinea Pigs, In Vitro Techniques, Nerve Tissue drug effects, Acetylcholine pharmacology, Cocaine pharmacology, Histamine pharmacology, Insecticides pharmacology, Muscle Contraction drug effects, Muscle, Smooth drug effects, Neostigmine pharmacology, Nicotine pharmacology, Pentolinium Tartrate pharmacology, Piperazines pharmacology, Procaine pharmacology, Scopolamine pharmacology, Serotonin pharmacology, Sympathomimetics pharmacology
Published
1966
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3. Inhibition of the taenia of the guinea-pig caecum by acetylcholine, nicotine or 5-hydroxytryptamine.

Author

Akubue PI

Subjects
Animals, Cocaine pharmacology, Ergoloid Mesylates pharmacology, Guanethidine pharmacology, Guinea Pigs, Hexamethonium Compounds pharmacology, Histamine pharmacology, Isoproterenol pharmacology, Norepinephrine pharmacology, Pentolinium Tartrate pharmacology, Phenoxybenzamine pharmacology, Piperazines pharmacology, Procaine pharmacology, Reserpine pharmacology, Scopolamine pharmacology, Sympatholytics pharmacology, Acetylcholine pharmacology, Cecum drug effects, Nicotine pharmacology, Serotonin pharmacology
Published
1966
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4. The site of action of drugs on the isolated taenia caeci from the guinea-pig.

Author

Akubue PI

Subjects
Animals, Cecum drug effects, Female, Guinea Pigs, In Vitro Techniques, Male, Acetylcholine pharmacology, Cocaine pharmacology, Hexamethonium Compounds pharmacology, Histamine pharmacology, Histamine H1 Antagonists pharmacology, Insecticides pharmacology, Lysergic Acid Diethylamide pharmacology, Mecamylamine pharmacology, Morphine pharmacology, Muscle Contraction drug effects, Nicotine pharmacology, Piperazines pharmacology, Procaine pharmacology, Scopolamine pharmacology, Serotonin pharmacology, Sympathomimetics pharmacology
Published
1966
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