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Your search keyword '"Minor, Samuel"' showing total 2 results
Start Over Author "Minor, Samuel" Topic septic shock
2 results on '"Minor, Samuel"'

1. The unrestricted global effort to complete the COOL trial

Author

Kirkpatrick, Andrew W., Coccolini, Federico, Tolonen, Matti, Minor, Samuel, Catena, Fausto, Gois, Jr., Emanuel, Doig, Christopher J., Hill, Michael D., Ansaloni, Luca, Chiarugi, Massimo, Tartaglia, Dario, Ioannidis, Orestis, Sugrue, Michael, Colak, Elif, Hameed, S. Morad, Lampela, Hanna, Agnoletti, Vanni, McKee, Jessica L., Garraway, Naisan, Sartelli, Massimo, Ball, Chad G., Parry, Neil G., Voght, Kelly, Julien, Lisa, Kroeker, Jenna, Roberts, Derek J., Faris, Peter, Tiruta, Corina, Moore, Ernest E., Ammons, Lee Anne, Anestiadou, Elissavet, Bendinelli, Cino, Bouliaris, Konstantinos, Carroll, Rosemarry, Ceresoli, Marco, Favi, Francesco, Gurrado, Angela, Rezende-Neto, Joao, Isik, Arda, Cremonini, Camilla, Strambi, Silivia, Koukoulis, Georgios, Testini, Mario, Trpcic, Sandy, Pasculli, Alessandro, Picariello, Erika, Abu-Zidan, Fikri, Adeyeye, Ademola, Augustin, Goran, Alconchel, Felipe, Altinel, Yuksel, Hernandez Amin, Luz Adriana, Aranda-Narváez, José Manuel, Baraket, Oussama, Biffl, Walter L., Baiocchi, Gian Luca, Bonavina, Luigi, Brisinda, Giuseppe, Cardinali, Luca, Celotti, Andrea, Chaouch, Mohamed, Chiarello, Maria, Costa, Gianluca, de’Angelis, Nicola, De Manzini, Nicolo, Delibegovic, Samir, Di Saverio, Salomone, De Simone, Belinda, Dubuisson, Vincent, Fransvea, Pietro, Garulli, Gianluca, Giordano, Alessio, Gomes, Carlos, Hayati, Firdaus, Huang, Jinjian, Ibrahim, Aini Fahriza, Huei, Tan Jih, Jailani, Ruhi Fadzlyana, Khan, Mansoor, Luna, Alfonso Palmieri, Malbrain, Manu L. N. G., Marwah, Sanjay, McBeth, Paul, Mihailescu, Andrei, Morello, Alessia, Mulita, Francesk, Murzi, Valentina, Mohammad, Ahmad Tarmizi, Parmar, Simran, Pak, Ajay, Wong, Michael Pak-Kai, Pantalone, Desire, Podda, Mauro, Puccioni, Caterina, Rasa, Kemal, Ren, Jianan, Roscio, Francesco, Gonzalez-Sanchez, Antonio, Sganga, Gabriele, Scheiterle, Maximilian, Slavchev, Mihail, Smirnov, Dmitry, Tosi, Lorenzo, Trivedi, Anand, Vega, Jaime Andres Gonzalez, Waledziak, Maciej, Xenaki, Sofia, Winter, Desmond, Wu, Xiuwen, Zakaria, Andee Dzulkarnean, and Zakaria, Zaidi

Published
2023
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2. Impact of methylene blue in addition to norepinephrine on the intestinal microcirculation in experimental septic shock.

Author

Nantais, Jordan, Dumbarton, Tristan C., Farah, Nizam, Maxan, Alexander, Zhou, Juan, Minor, Samuel, and Lehmann, Christian

Subjects
METHYLENE blue, NORADRENALINE, MICROCIRCULATION, SEPTIC shock, VASOCONSTRICTORS, LIPOPOLYSACCHARIDES, THERAPEUTICS
Abstract

Methylene blue (MB) has been used with some success as a treatment for the vasoplegia of vasopressor-refractory septic shock. The putative mechanism of action ofMBis the inhibition of endothelial nitric oxide within the microvasculature and improved responsiveness to endogenous catecholamines (norepinephrine (NE)). However, to date, no study has demonstrated the microcirculatory effect of methylene blue in septic shock. The objective of this randomized, controlled, animal study was to show, in an experimentally-induced, septic shock model in rats, the effects of MB and NE on global hemodynamics and the microcirculation. Mean arterial pressure (MAP) was drastically reduced following bacterial endotoxin (lipopolysaccharide, LPS) administration in animals not receiving vasopressors. Only the combination of NE +MB restored MAP to control levels by the end of the three hour experiment. Intravital microscopy of the microcirculation was performed in the terminal ileum in order to examine functional capillary density in intestinal muscle layers and the mucosa, as well as leukocyte activation in venules (rolling, adhesion to the endothelium). Untreated LPS animals showed a significant increase in leukocyte adhesion and a decrease in capillary perfusion in the intestinal microcirculation. In groups receiving NE or NE+MB, we observed a significant decrease in leukocyte adhesion and improved functional capillary density, indicating that microvasculature functionwas improved. This study suggests that methylene blue may be able to improve hemodynamics while preserving microvascular function in septic shock. [ABSTRACT FROM AUTHOR]

Published
2014
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