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Background: The role of statins in sepsis patients with acute kidney injury (AKI) is still unclear. This study was done to evaluate the effects of oral Simvastatin and low dose intravenous norepinephrine as an adjunctive therapy in early acute kidney injury associated with sepsis. Methods: we enrolled 60 patients with severe sepsis had early diagnosed acute kidney injury with high plasma NGAL* test. They were randomly assigned to 2 groups; Group A (n =30) received oral Simvastatin 80 mg/day and low dose intravenous norepinephrine (2 to 4 μg /min) plus conventional sepsis treatment., Group B (n =30) received only conventional sepsis treatment. Then both were followed by: CRP*, PCT*, SOFA score* monitoring, RIFLE criteria* and Need for organ supportive measures, Length of ICU stay and 28-day Mortality. Results: Group A showed no any statistically significant differences except a significant reduction in Mean SOFA score on day 2 and 3 only (p value = 0.012 and 0.013 respectively) and in need for vasopressor (p value = 0.004). Conclusions: Simvastatin and low dose norepinephrine did not show any improvement in patients with sepsis associated AKI. Abb. NGAL: Neutrophil gelatinase-associated lipocalin, CRP:C-reactive protein, PCT: Procalcitonin, SOFA score: Sequential organ failure assessment score, RIFLE criteria: Risk, Injury, and Failure, Loss and End-stage renal disease. Keywords: Critical; Sepsis; AKI; Norepinephrine; simvastatin REFERENCES Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Jama. 2016;315(8):801-10. Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, et al. 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