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This study was carried out to evaluate the effects of nano selenium (nano-Se) and conjugated linoleic acid (CLA) on performance, biometric and blood parameters and selenoprotein W1 (SEPW1) and lipid gene expression in male Moghani lambs. Thirty male Moghani lambs, 3-months-old and weighing 30 ± 0.25 kg, were used in completely randomized design in a 2 x 3 factorial arrangement with dietary supplemental the CLA (0 and 15 g/kg DM) and nano-Se (0, 1 and 2 mg/kg DM). The lambs were slaughtered on day 90 (end of experiment). Feeding a mixture of CLA and nano-Se tended to reduce the body weight of lambs comparing to the control group. The experimental diets had no impact on biometric parameters. Some blood parameters like high density lipoprotein (HDL), low density lipoprotein (LDL), thyroxine (T4), triiodothyronine (T3) and glutathione peroxidase (GPx) and glutathione peroxidase depended on dietary nano-Se supplementation (P<0.05); but glucose, triglycerides (TG), very low density lipoprotein (VLDL), total protein (TP) and cholesterol had no considerable effects. The results of qPCR analysis showed that nano-Se supplemental at highest level (2 mg/kg DM) increased gene expression of GPX1 and SEPW1 in liver (P<0.05). Dietary inclusion of CLA enhanced the peroxisome proliferator-activated receptor gamma expression and decreased stearoyl COA desaturase 1 genes in tail (P<0.01). In conclusion, nano-Se and CLA differently increased the gene expression in liver and tail and had good impacts on some blood parameters; suggesting that nano-Se and CLA have not synergism interaction in the above parameters. [ABSTRACT FROM AUTHOR]

The early interest in selenium (Se) focused on its toxicity, but since 1957 it has been recognized as an essential dietary element. The diet is the major Se source and approximately 80% of dietary Se is absorbed, depending on the type of food consumed. In several regions of the world, the content of Se in diets has been estimated as insufficient. The dietary requirement for Se for most species is about 0.3 ppm. Deficiencies of Se in animals have been confirmed under natural grazing conditions in many countries. Symptoms of deficiencies such as white muscle disease occur primarily in young calves or lambs born in low Se regions and thus we need to provide sufficient amounts in animal diets. Numerous studies have demonstrated that Se plays an important role in animal health. Therefore, this review gives a brief outline of the current information on the physical, chemical and metabolic properties of Se, oxidative stress, antioxidant defense, dietary requirement, deficiency, toxicity and effects of Se on fertility and performance. [ABSTRACT FROM AUTHOR]