Search

Your search keyword '"Rosati RL"' showing total 2 results
Start Over Author "Rosati RL" Topic selective estrogen receptor modulators
2 results on '"Rosati RL"'

1. Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists.

Author

Chesworth R, Zawistoski MP, Lefker BA, Cameron KO, Day RF, Mangano FM, Rosati RL, Colella S, Petersen DN, Brault A, Lu B, Pan LC, Perry P, Ng O, Castleberry TA, Owen TA, Brown TA, Thompson DD, and DaSilva-Jardine P

Subjects
Cell Line, Tumor, Cell Proliferation drug effects, Estrogen Receptor alpha chemistry, Estrogen Receptor beta chemistry, Female, Humans, Inhibitory Concentration 50, Ligands, Protein Binding, Selective Estrogen Receptor Modulators pharmacology, Structure-Activity Relationship, Tetrahydroisoquinolines chemical synthesis, Selective Estrogen Receptor Modulators chemical synthesis, Tetrahydroisoquinolines pharmacology
Abstract

Two series of 6-hydroxy and 7-hydroxy tetrahydroisoquinolines were prepared. Evaluating a range of C-1, C-4, and N-substituents led to the discovery of ER alpha and ER beta selective analogs.

Published
2004
Full Text
View/download PDF

2. Enzyme-catalyzed asymmetric deacylation for the preparation of lasofoxifene (CP-336156), a selective estrogen receptor modulator.

Author

Yang X, Reinhold AR, Rosati RL, and Liu KK

Subjects
Catalysis, Dealkylation, Hydrolysis, Stereoisomerism, X-Ray Diffraction, Pyrrolidines chemical synthesis, Selective Estrogen Receptor Modulators chemical synthesis, Tetrahydronaphthalenes chemical synthesis
Abstract

[structure] selective estrogen receptor modulator (SERM), Lasofoxifene (CP-336156), was prepared by an enzyme-catalyzed asymmetric deacylation with high optical purity and excellent yield even though the hydrolytic site is remote from the chiral centers.

Published
2000
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results