6 results on '"Quarato, Pier Paolo"'
Search Results
2. Temporal lobe epilepsy surgery in children and adults: A multicenter study.
- Author
-
Barba, Carmen, Cossu, Massimo, Guerrini, Renzo, Di Gennaro, Giancarlo, Villani, Flavio, De Palma, Luca, Grisotto, Laura, Consales, Alessandro, Battaglia, Domenica, Zamponi, Nelia, d'Orio, Piergiorgio, Revay, Martina, Rizzi, Michele, Casciato, Sara, Esposito, Vincenzo, Quarato, Pier Paolo, Di Giacomo, Roberta, Didato, Giuseppe, Pastori, Chiara, and Pavia, Giusy Carfi
- Subjects
TEMPORAL lobe epilepsy ,TEMPORAL lobectomy ,EPILEPSY surgery ,CHILDHOOD epilepsy ,PEDIATRIC surgery ,ADULTS - Abstract
Objective: To assess seizure and cognitive outcomes and their predictors in children (<16 years at surgery) and adults undergoing temporal lobe epilepsy (TLE) surgery in eight Italian centers. Methods: This is a retrospective multicenter study. We performed a descriptive analysis and subsequently carried out multivariable mixed‐effect models corrected for multiple comparisons. Results: We analyzed data from 511 patients (114 children) and observed significant differences in several clinical features between adults and children. The possibility of achieving Engel class IA outcome and discontinuing antiepileptic drugs (AEDs) at last follow‐up (FU) was significantly higher in children (P =.006 and <.0001). However, percentages of children and adults in Engel class I at last FU (mean ± SD, 45.9 ± 17 months in children; 45.9 ± 20.6 months in adults) did not differ significantly. We identified different predictors of seizure outcome in children vs adults and at short‐ vs long‐term FU. The only variables consistently associated with class I outcome over time were postoperative electroencephalography (EEG) in adults (abnormal, improved,odds ratio [OR] = 0.414, P =.023, Q = 0.046 vs normal, at 2‐year FU and abnormal, improved, OR = 0.301, P =.001, Q = 0.002 vs normal, at last FU) and the completeness of resection of temporal magnetic resonance (MR) abnormalities other than hippocampal sclerosis in children (OR = 7.93, P =.001, Q = 0.003, at 2‐year FU and OR = 45.03, P <.0001, Q < 0.0001, at last FU). Cognitive outcome was best predicted by preoperative performances in either age group. Significance: Clinical differences between adult and pediatric patients undergoing TLE surgery are reflected in differences in long‐term outcomes and predictors of failures. Children are more likely to achieve sustained seizure freedom and withdraw AEDs after TLE surgery. Earlier referral should be encouraged as it can improve surgical outcome. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
3. Epilepsy surgery of 'low grade epilepsy associated neuroepithelial tumors': A retrospective nationwide Italian study.
- Author
-
Giulioni, Marco, Marucci, Gianluca, Pelliccia, Veronica, Gozzo, Francesca, Barba, Carmen, Didato, Giuseppe, Villani, Flavio, Di Gennaro, Giancarlo, Quarato, Pier Paolo, Esposito, Vincenzo, Consales, Alessandro, Martinoni, Matteo, Vornetti, Gianfranco, Zenesini, Corrado, Efisio Marras, Carlo, Specchio, Nicola, Palma, Luca, Rocchi, Raffaele, Giordano, Flavio, and Tringali, Giovanni
- Subjects
EPILEPSY surgery ,GLIOMAS ,NEUROPSYCHOLOGY ,TUMOR surgery ,CONVULSIONS -- Risk factors - Abstract
Objective To analyze the attitude and results of Italian epilepsy surgery centers in the surgical management of 'low grade epilepsy associated neuroepithelial tumors' ( LEATs). Methods We conducted a retrospective study enrolling 339 consecutive patients with LEATs who underwent surgery between January 2009 and June 2015 at eight Italian epilepsy surgery centers. We compared demographic, clinical, pathologic, and surgical features of patients with favorable (Engel class I) and unfavorable (Engel class II, III, and IV) seizure outcome. In addition, we compared patients with tumor-associated focal cortical dysplasia (FCD) and patients with solitary tumors to identify factors correlated with FCD diagnosis. Results Fifty-five (98.2%) of 56 patients with medically controlled epilepsy were seizure-free after surgery, compared to 249 (88.0%) of 283 patients with refractory epilepsy. At multivariate analysis, three variables independently predict unfavorable seizure outcome in the drug-resistant group. Age at surgery is largely the most significant (p = 0.001), with an odds ratio (OR) of 1.04. This means that the probability of seizure recurrence grows by 4% for every waited year. The resection site is also significant (p = 0.039), with a relative risk (RR) of 1.99 for extratemporal tumors. Finally, the completeness of tumor resection has a trend toward significance (p = 0.092), with an RR of 1.82 for incomplete resection. Among pediatric patients, a longer duration of epilepsy was significantly associated with preoperative neuropsychological deficits (p < 0.001). A statistically significant association was observed between FCD diagnosis and the following variables: tailored surgery (p < 0.001), temporal resection (p = 0.001), and surgical center (p = 0.012). Significance Our nationwide LEATs study gives important insights on factors predicting seizure outcome in refractory epilepsy and determining variability in FCD detection. Timely surgery, regardless of pharmacoresistance and oriented to optimize epileptologic, neuropsychological, and oncologic outcomes should be warranted. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
4. Temporal lobe epilepsy surgery in children and adults: A multicenter study
- Author
-
Barba, Carmen, Cossu, Massimo, Guerrini, Renzo, Di Gennaro, Giancarlo, Villani, Flavio, De Palma, Luca, Grisotto, Laura, Consales, Alessandro, Battaglia, Domenica, Zamponi, Nelia, d’Orio, Piergiorgio, Revay, Martina, Rizzi, Michele, Casciato, Sara, Esposito, Vincenzo, Quarato, Pier Paolo, Di Giacomo, Roberta, Didato, Giuseppe, Pastori, Chiara, Pavia, Giusy Carfi, Pellacani, Simona, Matta, Giulia, Pacetti, Mattia, Tamburrini, Gianpiero, Cesaroni, Elisabetta, Colicchio, Gabriella, Vatti, Giampaolo, Asioli, Sofia, Caulo, Massimo, Marras, Carlo Efisio, Tassi, Laura, D’Aniello, Alfredo, Morace, Roberta, De Curtis, Marco, Deleo, Francesca, Giordano, Flavio, De Benedictis, Alessandro, Prato, Giulia, Perulli, Marco, Barba C., Cossu M., Guerrini R., Di Gennaro G., Villani F., De Palma L., Grisotto L., Consales A., Battaglia D., Zamponi N., d'Orio P., Revay M., Rizzi M., Casciato S., Esposito V., Quarato P.P., Di Giacomo R., Didato G., Pastori C., Carfi Pavia G., Pellacani S., Matta G., Pacetti M., Tamburrini G., Cesaroni E., Colicchio G., Vatti G., Asioli S., Caulo M., Marras C.E., and Tassi L.
- Subjects
0301 basic medicine ,Male ,Electroencephalography ,Neuropsychological Tests ,Hippocampus ,Neurosurgical Procedures ,Epilepsy ,0302 clinical medicine ,Postoperative Complications ,Cognition ,Epilepsy surgery ,Child ,seizure outcome ,medicine.diagnostic_test ,Age Factors ,Prognosis ,Temporal Lobe ,Malformations of Cortical Development ,Neurology ,Child, Preschool ,epilepsy surgery ,Anticonvulsants ,Female ,Adult ,medicine.medical_specialty ,Referral ,Adolescent ,Temporal lobe ,03 medical and health sciences ,Young Adult ,Settore MED/39 - NEUROPSICHIATRIA INFANTILE ,children ,Internal medicine ,Early Medical Intervention ,medicine ,Humans ,Preschool ,Retrospective Studies ,Hippocampal sclerosis ,Sclerosis ,business.industry ,Magnetic resonance imaging ,Odds ratio ,cognitive outcome ,medicine.disease ,030104 developmental biology ,Epilepsy, Temporal Lobe ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Objective: To assess seizure and cognitive outcomes and their predictors in children (
- Full Text
- View/download PDF
5. Long-term seizure outcome in frontal lobe epilepsy surgery.
- Author
-
Morace, Roberta, Casciato, Sara, Quarato, Pier Paolo, Mascia, Addolorata, D'Aniello, Alfredo, Grammaldo, Liliana G., De Risi, Marco, Di Gennaro, Giancarlo, and Esposito, Vincenzo
- Subjects
- *
TEMPORAL lobectomy , *EPILEPSY , *TUMOR grading , *FRONTAL lobe , *ENCEPHALITIS , *SCALP , *MAGNETIC resonance imaging - Abstract
Abstract Purpose The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery. Method This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001–2014), followed up for at least 2 years (mean: 8.7 years). All patients underwent noninvasive presurgical evaluation and/or invasive electroencephalography (EEG) monitoring when nonconcordant data were obtained or epileptogenic zone was hypothesized to be close to the eloquent cortex. Electroclinical, neuroimaging, surgical data, and histology were compared to seizure outcome. Results Mean epilepsy duration was 19 years; mean age at surgery was 31.6 years. Preoperative magnetic resonance imaging (MRI) showed a frontal lesion in 86.4 % of cases. Scalp video-electroencephalography (VEEG) monitoring detected a focal ictal onset in 90% of cases. Twenty-seven patients (61.4%) underwent invasive recordings. Resections involved dorsolateral (47.7%), medial (9%), orbital (13.6%), and rolandic (13.6%) region. Lobectomy within functional boundaries was performed in the remaining 7 cases (16%). Transient and permanent neurological deficits were observed in 2 and 3 cases, respectively. Histology revealed focal cortical dysplasia (45.5%), World Health Organization (WHO) I–II grade tumors (15.9%), gliosis (22.7%), vascular malformations (4.5%), Rasmussen encephalitis (6.8%), and normal tissue (4.5%). At last observation 68.1% of patients were in Engel's class I, 11.4% in class II, 9% in class III, and 11.4% in class IV. A favorable outcome was associated with focal ictal scalp EEG onset (p = 0.0357). Conclusion Surgery is a safe treatment option in drug-resistant FLE with a satisfying long-term outcome. These data highlight the importance of an appropriate selection of potential surgical candidates. Highlights • Surgery is a safe option in drug-resistant FLE with a satisfying long-term outcome. • The presence of focal lesions predicts favorable outcome. • Focal ictal scalp EEG onset is associated with a favorable long-term outcome. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
6. Epilepsy surgery of 'low grade epilepsy associated neuroepithelial tumors': A retrospective nationwide Italian study
- Author
-
Gianfranco Vornetti, Gabriella Colicchio, Giovanni Tringali, Renzo Guerrini, Giancarlo Di Gennaro, Guido Rubboli, Marco Giulioni, Raffaele Rocchi, Pier Paolo Quarato, Paolo Nozza, Gianluca Marucci, Francesca Gozzo, Matteo Martinoni, Alessandro Consales, Vincenzo Esposito, Flavio Villani, Massimo Cossu, Luca De Palma, Carmen Barba, Giorgio Lo Russo, Veronica Pelliccia, Nicola Specchio, Flavio Giordano, Giuseppe Didato, Carlo Efisio Marras, Paolo Tinuper, Corrado Zenesini, Francesco Cardinale, DIPARTIMENTO DI EMATOLOGIA E SCIENZE ONCOLOGICHE 'L. e A. SERAGNOLI', DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE, DIPARTIMENTO DI SCIENZE MEDICHE E CHIRURGICHE, Facolta' di MEDICINA e CHIRURGIA, Da definire, AREA MIN. 06 - Scienze mediche, Giulioni, Marco, Marucci, Gianluca, Pelliccia, Veronica, Gozzo, Francesca, Barba, Carmen, Didato, Giuseppe, Villani, Flavio, Di Gennaro, Giancarlo, Quarato, Pier Paolo, Esposito, Vincenzo, Consales, Alessandro, Martinoni, Matteo, Vornetti, Gianfranco, Zenesini, Corrado, Carlo, Efisio Marra, Specchio, Nicola, De Palma, Luca, Rocchi, Raffaele, Giordano, Flavio, Tringali, Giovanni, Nozza, Paolo, Colicchio, Gabriella, Rubboli, Guido, Lo Russo, Giorgio, Guerrini, Renzo, Tinuper, Paolo, Cardinale, Francesco, and Cossu, Massimo
- Subjects
Male ,Drug Resistant Epilepsy ,Multivariate analysis ,Epilepsy ,0302 clinical medicine ,Glioneuronal tumors ,Retrospective Studie ,Neoplasms ,Epilepsy surgery ,Low-grade glial tumors ,Neuropsychological outcome ,Child ,Brain Neoplasms ,Neuropsychology ,Neoplasms, Neuroepithelial ,Treatment Outcome ,Focal cortical dysplasia ,Seizure outcome ,Adolescent ,Adult ,Female ,Follow-Up Studies ,Humans ,Italy ,Retrospective Studies ,Young Adult ,Neurology ,Neurology (clinical) ,030220 oncology & carcinogenesis ,Human ,Italy/epidemiology ,medicine.medical_specialty ,Drug Resistant Epilepsy/diagnosis ,Neuroepithelial ,Follow-Up Studie ,Brain Neoplasm ,03 medical and health sciences ,Neoplasms, Neuroepithelial/diagnosis ,Internal medicine ,Low-grade glial tumor ,medicine ,Glioneuronal tumor ,Brain Neoplasms/diagnosis ,business.industry ,Retrospective cohort study ,Odds ratio ,Cortical dysplasia ,medicine.disease ,Surgery ,Relative risk ,business ,030217 neurology & neurosurgery - Abstract
none 28 no Objective: To analyze the attitude and results of Italian epilepsy surgery centers in the surgical management of âlow grade epilepsy associated neuroepithelial tumorsâ (LEATs). Methods: We conducted a retrospective study enrolling 339 consecutive patients with LEATs who underwent surgery between January 2009 and June 2015 at eight Italian epilepsy surgery centers. We compared demographic, clinical, pathologic, and surgical features of patients with favorable (Engel class I) and unfavorable (Engel class II, III, and IV) seizure outcome. In addition, we compared patients with tumor-associated focal cortical dysplasia (FCD) and patients with solitary tumors to identify factors correlated with FCD diagnosis. Results: Fifty-five (98.2%) of 56 patients with medically controlled epilepsy were seizure-free after surgery, compared to 249 (88.0%) of 283 patients with refractory epilepsy. At multivariate analysis, three variables independently predict unfavorable seizure outcome in the drug-resistant group. Age at surgery is largely the most significant (p = 0.001), with an odds ratio (OR) of 1.04. This means that the probability of seizure recurrence grows by 4% for every waited year. The resection site is also significant (p = 0.039), with a relative risk (RR) of 1.99 for extratemporal tumors. Finally, the completeness of tumor resection has a trend toward significance (p = 0.092), with an RR of 1.82 for incomplete resection. Among pediatric patients, a longer duration of epilepsy was significantly associated with preoperative neuropsychological deficits (pÂ
- Published
- 2017
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.