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Your search keyword '"Tityus cambridgei"' showing total 2 results
Start Over Descriptor "Tityus cambridgei" Topic scorpion toxin
2 results on '"Tityus cambridgei"'

1. Amino acid sequence and function of a new α-toxin from the Amazonian scorpion Tityus cambridgei

Author

Murgia, Anna Rosa, Batista, Cesar V.F., Prestipino, Gianfranco, and Possani, Lourival D.

Subjects
*SCORPION venom, *TOXINS, *AMINO acids, *PATCH-clamp techniques (Electrophysiology)
Abstract

A toxic peptide earlier denominated Tc48b [Toxicon 40 (2002) 557] was purified to homogeneity and its amino acid sequence determined. It has 64 amino acid residues stabilized by four disulfide bridges with a molecular weight of 7,385.2 atomic mass units (a.m.u.). It affects Na+-permeability in pituitary GH3 cells in culture, in a similar fashion as those reported for α-scorpion toxins, contrary to most of the New World scorpion toxins that are β-toxins. [Copyright &y& Elsevier]

Published
2004
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2. Tc1, from Tityus cambridgei , is the first member of a new subfamily of scorpion toxin that blocks K+ -channels

Author

Lourival D. Possani, Froylan Gómez-Lagunas, Sylvia M. Lucas, and Cesar Vicente Ferreira Batista

Subjects
Potassium Channels, Subfamily, Molecular Sequence Data, Neurotoxins, Biophysics, Scorpion, Scorpion Venoms, Peptide, Venom, Spodoptera, Tityus cambridgei, complex mixtures, Biochemistry, Cell Line, Scorpions, Mice, Structural Biology, biology.animal, Potassium Channel Blockers, Genetics, Animals, Amino Acid Sequence, Molecular Biology, Peptide sequence, chemistry.chemical_classification, K+-channel, Scorpion toxin, biology, Chemistry, Cell Biology, Amino acid, Shaker Superfamily of Potassium Channels, Peptides, Synaptosomes
Abstract

A new peptide, Tc1, containing only 23 amino acids closely packed by three disulfide bridges was isolated from the Amazonian scorpion Tityus cambridgei. It blocks reversibly the Shaker B K+-channels with a Kd of 65 nM and displaces binding of noxiustoxin to mouse brain synaptosome membranes. It is the shortest known peptide from scorpion venom that recognizes K+-channels and constitutes a new structural subfamily of toxin, classified as alphaKTx 13.1.

Published
2000
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