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2 results on '"dry sensation"'

1. Distinct combinations of variant ionotropic glutamate receptors mediate thermosensation and hygrosensation in Drosophila

Author

Zachary A Knecht, Ana F Silbering, Lina Ni, Mason Klein, Gonzalo Budelli, Rati Bell, Liliane Abuin, Anggie J Ferrer, Aravinthan DT Samuel, Richard Benton, and Paul A Garrity

Subjects
dry sensation, ionotropic receptor, Ir21a, Ir25a, Ir40a, Ir93a, Medicine, Science, Biology (General), QH301-705.5
Abstract

Ionotropic Receptors (IRs) are a large subfamily of variant ionotropic glutamate receptors present across Protostomia. While these receptors are most extensively studied for their roles in chemosensory detection, recent work has implicated two family members, IR21a and IR25a, in thermosensation in Drosophila. Here we characterize one of the most evolutionarily deeply conserved receptors, IR93a, and show that it is co-expressed and functions with IR21a and IR25a to mediate physiological and behavioral responses to cool temperatures. IR93a is also co-expressed with IR25a and a distinct receptor, IR40a, in a discrete population of sensory neurons in the sacculus, a multi-chambered pocket within the antenna. We demonstrate that this combination of receptors is required for neuronal responses to dry air and behavioral discrimination of humidity differences. Our results identify IR93a as a common component of molecularly and cellularly distinct IR pathways important for thermosensation and hygrosensation in insects.

Published
2016
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2. Distinct combinations of variant ionotropic glutamate receptors mediate thermosensation and hygrosensation in Drosophila

Author

Liliane Abuin, Zachary A Knecht, Lina Ni, Richard Benton, Ana F. Silbering, Paul A. Garrity, Aravinthan D. T. Samuel, Anggie J Ferrer, Gonzalo Budelli, Mason Klein, and Rati Bell

Subjects
0301 basic medicine, Subfamily, QH301-705.5, Science, Population, Sensory system, Biology, Ir25a, Receptors, Ionotropic Glutamate, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Ir93a, Ir21a, Animals, Drosophila Proteins, Biology (General), ionotropic receptor, education, Receptor, education.field_of_study, General Immunology and Microbiology, D. melanogaster, Behavior, Animal, General Neuroscience, Glutamate receptor, Membrane Proteins, Humidity, General Medicine, Anatomy, biology.organism_classification, Cell biology, Cold Temperature, 030104 developmental biology, Drosophila melanogaster, Ir40a, Medicine, dry sensation, Drosophila Protein, Ionotropic effect, Neuroscience, Research Article
Abstract

Ionotropic Receptors (IRs) are a large subfamily of variant ionotropic glutamate receptors present across Protostomia. While these receptors are most extensively studied for their roles in chemosensory detection, recent work has implicated two family members, IR21a and IR25a, in thermosensation in Drosophila. Here we characterize one of the most evolutionarily deeply conserved receptors, IR93a, and show that it is co-expressed and functions with IR21a and IR25a to mediate physiological and behavioral responses to cool temperatures. IR93a is also co-expressed with IR25a and a distinct receptor, IR40a, in a discrete population of sensory neurons in the sacculus, a multi-chambered pocket within the antenna. We demonstrate that this combination of receptors is required for neuronal responses to dry air and behavioral discrimination of humidity differences. Our results identify IR93a as a common component of molecularly and cellularly distinct IR pathways important for thermosensation and hygrosensation in insects. DOI: http://dx.doi.org/10.7554/eLife.17879.001

Published
2016

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