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Climate change and inter-annual variability cause variation in rainfall commencement and cessation which has consequences for the maize growing season length and thus impact yields. This study therefore sought to determine the spatially explicit optimum maize sowing dates to enable site specific recommendations in Nigeria. Gridded weather and soil data, crop management and cultivar were used to simulate maize yield from 1981-2019 at a scale of 0.5°. A total of 37 potential sowing dates between 1 March and 7 November at an interval of 7 days for each year were evaluated. The optimum sowing date was the date which maximizes yield at harvest, keeping all other management factors constant. The results show that optimum sowing dates significantly vary across the country with northern Nigeria having notably delayed sowing dates compared to southern Nigeria which has earlier planting dates. The long-term optimal sowing dates significantly (p

The German site selection procedure for a high-level nuclear waste repository is entering a stage in which preliminary safety assessments have to be conducted and the release of radionuclides has to be estimated for a large number of potential sites. Here, we present TransPyREnd, a 1D finite-differences code for modeling the transport of radionuclides in the subsurface at geological timescales. The code simulates the processes advection, diffusion, equilibrium sorption, decay of radionuclides, and the build-up of daughter nuclides. We summarize the modeled physical processes, their mathematical description and our numerical approach to solve the governing equations. Finally, two simple tests are shown, one considering diffusion, sorption, and radioactive decay, the other involving diffusion and a radioactive decay chain. In both tests, the code shows good agreement with the reference solutions. Caveats of the model and future additions are discussed.

Summary: The recurrent emerging of novel viral variants of concern (VOCs) with evasion of preexisting antibody immunity upholds severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) case numbers and maintains a persistent demand for updated therapies. We selected the patient-derived antibody CV38-142 based on its potency and breadth against the VOCs Alpha, Beta, Gamma, and Delta for preclinical development into a therapeutic. CV38-142 showed in vivo efficacy in a Syrian hamster VOC infection model after post-exposure and therapeutic application and revealed a favorable safety profile in a human protein library screen and tissue cross-reactivity study. Although CV38-142 targets the same viral surface as sotrovimab, which maintains activity against Omicron, CV38-142 did not neutralize the Omicron lineages BA.1 and BA.2. These results highlight the contingencies of developing antibody therapeutics in the context of antigenic drift and reinforce the need to develop broadly neutralizing variant-proof antibodies against SARS-CoV-2.

The Federal Company for Radioactive Waste Disposal (BGE) is responsible for the search for a site with the best possible safety for the disposal of high-level radioactive waste in Germany. The site selection procedure is regulated in a law that was adopted by the German Federal Parliament (Repository Site Selection Act – StandAG, 2017, last updated 2020) and aims to be a participatory, transparent, learning, and self-questioning process based on scientific expertise. The first step of the first phase of the site selection procedure was completed in September 2020 and resulted in the identification of sub-areas that give reason to expect favorable geological conditions for the long-term storage of nuclear waste in the subsurface. These sub-areas cover approximately 54 % of Germany and are located in three different host rocks: rock salt – halite, claystone, and crystalline rock. The challenge for the next step is to find suitable siting regions within the previously determined sub-areas that are then considered further in the next phase of the site selection procedure. In the following, the methodology of the so-called representative preliminary safety analyses is described, which constitute one of the tools to identify siting regions, and some first insight on how they are planned to be implemented in practice is given.

Bias-correction methods are commonly applied to climate model data in hydrological climate impact studies. This is due to the often large deviations between simulated and observed climate variables. These biases may cause unrealistic simulation results when directly using the climate model data as input for hydrological models. Our analysis of the EURO-CORDEX (Coordinated Downscaling Experiment for Europe) data for the Northwestern part of Germany showed substantial biases for all climatological input variables needed by the hydrological model PANTA RHEI. The sensitivity for climatological input data demonstrated that changes in only one climate variable significantly affect the simulated average discharge and mean annual peak flow. The application of bias correction methods of different complexity on the climate model data improved the plausibility of hydrological modeling results for the historical period 1971−2000. The projections for the future period 2069−2099 for high flows indicate on average small changes for representative concentration pathway (RCP) 4.5 and an increase of approximately 10% for RCP8.5 when applying non-bias corrected climate model data. These values significantly differed when applying bias correction. The bias correction methods were evaluated in terms of their ability to (a) maintain the change signal for precipitation and (b) the goodness of fit for hydrological parameters for the historical period. Our results for this evaluation indicated that no bias correction method can explicitly be preferred over the others.