5 results on '"Jan Bettgenhaeuser"'
Number of results to display per page
Search Results
2. Fonio millet genome unlocks African orphan crop diversity for agriculture in a changing climate
- Author
-
Michael Abrouk, Hanin Ibrahim Ahmed, Philippe Cubry, Denisa Šimoníková, Stéphane Cauet, Yveline Pailles, Jan Bettgenhaeuser, Liubov Gapa, Nora Scarcelli, Marie Couderc, Leila Zekraoui, Nagarajan Kathiresan, Jana Čížková, Eva Hřibová, Jaroslav Doležel, Sandrine Arribat, Hélène Bergès, Jan J. Wieringa, Mathieu Gueye, Ndjido A. Kane, Christian Leclerc, Sandrine Causse, Sylvie Vancoppenolle, Claire Billot, Thomas Wicker, Yves Vigouroux, Adeline Barnaud, and Simon G. Krattinger
- Subjects
Science - Abstract
Fonio millet is a fast growing orphan cereal crop with a great potential for dryland agriculture. Here, the authors report chromosome-scale reference genome assembly and population genomic resources to shed light on genetic diversity, population structure and domestication of fonio millet.
- Published
- 2020
- Full Text
- View/download PDF
3. Different Stress-Induced Calcium Signatures Are Reported by Aequorin-Mediated Calcium Measurements in Living Cells of Aspergillus fumigatus.
- Author
-
Alberto Muñoz, Margherita Bertuzzi, Jan Bettgenhaeuser, Nino Iakobachvili, Elaine M Bignell, and Nick D Read
- Subjects
Medicine ,Science - Abstract
Aspergillus fumigatus is an inhaled fungal pathogen of human lungs, the developmental growth of which is reliant upon Ca2+-mediated signalling. Ca2+ signalling has regulatory significance in all eukaryotic cells but how A. fumigatus uses intracellular Ca2+ signals to respond to stresses imposed by the mammalian lung is poorly understood. In this work, A. fumigatus strains derived from the clinical isolate CEA10, and a non-homologous recombination mutant ΔakuBKU80, were engineered to express the bioluminescent Ca2+-reporter aequorin. An aequorin-mediated method for routine Ca2+ measurements during the early stages of colony initiation was successfully developed and dynamic changes in cytosolic free calcium ([Ca2+]c) in response to extracellular stimuli were measured. The response to extracellular challenges (hypo- and hyper-osmotic shock, mechanical perturbation, high extracellular Ca2+, oxidative stress or exposure to human serum) that the fungus might be exposed to during infection, were analysed in living conidial germlings. The 'signatures' of the transient [Ca2+]c responses to extracellular stimuli were found to be dose- and age-dependent. Moreover, Ca2+-signatures associated with each physico-chemical treatment were found to be unique, suggesting the involvement of heterogeneous combinations of Ca2+-signalling components in each stress response. Concordant with the involvement of Ca2+-calmodulin complexes in these Ca2+-mediated responses, the calmodulin inhibitor trifluoperazine (TFP) induced changes in the Ca2+-signatures to all the challenges. The Ca2+-chelator BAPTA potently inhibited the initial responses to most stressors in accordance with a critical role for extracellular Ca2+ in initiating the stress responses.
- Published
- 2015
- Full Text
- View/download PDF
4. The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics
- Author
-
Antonín Dreiseitl, Rosemary Bayles, Peter Emmrich, Brian J. Steffenson, Matthew J. Moscou, John N. Ferguson, Inmaculada Hernández-Pinzón, Amelia Hubbard, Brande B. H. Wulff, Robbie Waugh, Andrew Marc Dawson, Jodie Taylor, Matthew Gardiner, Eric R. Ward, Jan Bettgenhaeuser, Phon Green, Matthew Smoker, Bettgenhaeuser, Jan [0000-0002-6901-1774], Hernández-Pinzón, Inmaculada [0000-0003-3711-2893], Green, Phon [0000-0002-1968-0574], Waugh, Robbie [0000-0003-1045-3065], Steffenson, Brian J [0000-0001-7961-5363], Wulff, Brande B H [0000-0003-4044-4346], Dreiseitl, Antonín [0000-0002-9137-3210], Moscou, Matthew J [0000-0003-2098-6818], Apollo - University of Cambridge Repository, and Wulff, Brande BH [0000-0003-4044-4346]
- Subjects
Agricultural genetics ,Crops, Agricultural ,Ribosomal Proteins ,Science ,49/23 ,General Physics and Astronomy ,Locus (genetics) ,Biology ,Host Specificity ,General Biochemistry, Genetics and Molecular Biology ,631/449/2661/2666 ,Crop ,Puccinia ,Plant Immunity ,Receptors, Immunologic ,Allele ,Biotic ,Pathogen ,Gene ,Alleles ,Triticum ,631/449/2169 ,Plant Diseases ,Plant Proteins ,Genetics ,Multidisciplinary ,45 ,Host (biology) ,article ,45/77 ,food and beverages ,Hordeum ,General Chemistry ,Adaptation, Physiological ,Complementation ,Plant Breeding ,embryonic structures ,631/449/711 ,Edible Grain ,631/208/8 ,Powdery mildew - Abstract
Crop losses caused by plant pathogens are a primary threat to stable food production. Stripe rust (Puccinia striiformis) is a fungal pathogen of cereal crops that causes significant, persistent yield loss. Stripe rust exhibits host species specificity, with lineages that have adapted to infect wheat and barley. While wheat stripe rust and barley stripe rust are commonly restricted to their corresponding hosts, the genes underlying this host specificity remain unknown. Here, we show that three resistance genes, Rps6, Rps7, and Rps8, contribute to immunity in barley to wheat stripe rust. Rps7 cosegregates with barley powdery mildew resistance at the Mla locus. Using transgenic complementation of different Mla alleles, we confirm allele-specific recognition of wheat stripe rust by Mla. Our results show that major resistance genes contribute to the host species specificity of wheat stripe rust on barley and that a shared genetic architecture underlies resistance to the adapted pathogen barley powdery mildew and non-adapted pathogen wheat stripe rust., The genes underlying stripe rust host specificity between wheat and barley remain unknown. Here, the authors report that Rps6, Rps7 and Rps8 determine host species specificity in barley at different stages of the pathogen lifecycle and the barley powdery mildew immune receptor Mla8 and Rps7 are the same gene.
- Published
- 2021
5. Fonio millet genome unlocks African orphan crop diversity for agriculture in a changing climate
- Author
-
Ndjido Ardo Kane, Yves Vigouroux, Denisa Šimoníková, Leila Zekraoui, Jaroslav Dolezel, Nagarajan Kathiresan, Sandrine Causse, Michael Abrouk, Thomas Wicker, Sandrine Arribat, Claire Billot, Stéphane Cauet, Simon G. Krattinger, Jana Cizkova, Sylvie Vancoppenolle, Adeline Barnaud, E. Hribova, Hélène Bergès, Philippe Cubry, Jan Bettgenhaeuser, Mathieu Gueye, Hanin Ibrahim Ahmed, Liubov Gapa, Nora Scarcelli, Yveline Pailles, Jan J. Wieringa, Christian Leclerc, Marie Couderc, University of Zurich, Barnaud, Adeline, Krattinger, Simon G, King Abdullah University of Science and Technology (KAUST), Diversité, adaptation, développement des plantes (UMR DIADE), Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Institute of Experimental Botany of the Czech Academy of Sciences (IEB / CAS), Czech Academy of Sciences [Prague] (CAS), Centre National de Ressources Génomiques Végétales (CNRGV), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Naturalis Biodiversity Center [Leiden], Institut Fondamental d'Afrique Noire (IFAN), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Senegalese Agricultural Research Institute, LMI Adaptation des Plantes et microorganismes associés aux Stress Environnementaux [Dakar] (LAPSE), Institut de Recherche pour le Développement (IRD), Amélioration génétique et adaptation des plantes méditerranéennes et tropicales (UMR AGAP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universität Zürich [Zürich] = University of Zurich (UZH), European Regional Development Fund OPVVV project 'Plants as a tool for sustainable development' CZ.02.1.01/0.0/0.0/16_019/0000827, ANR-16-IDEX-0006,MUSE,MUSE(2016), ANR-10-LABX-0001,AGRO,Agricultural Sciences for sustainable Development(2010), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)
- Subjects
0106 biological sciences ,0301 basic medicine ,[SDV]Life Sciences [q-bio] ,Digitaria ,General Physics and Astronomy ,580 Plants (Botany) ,01 natural sciences ,Plant breeding ,F30 - Génétique et amélioration des plantes ,Domestication ,0302 clinical medicine ,10126 Department of Plant and Microbial Biology ,lcsh:Science ,2. Zero hunger ,Molecular breeding ,0303 health sciences ,Multidisciplinary ,Diversité génétique (comme ressource) ,Agroforestry ,Domestication des plantes ,phytogénétique ,food and beverages ,Agriculture ,3100 General Physics and Astronomy ,Genome, Plant ,Agricultural genetics ,Plant domestication ,Science ,Climate Change ,Context (language use) ,1600 General Chemistry ,Genetics and Molecular Biology ,Biology ,Article ,General Biochemistry, Genetics and Molecular Biology ,génomique ,Evolution, Molecular ,03 medical and health sciences ,Ressource génétique végétale ,Variation génétique ,Species Specificity ,1300 General Biochemistry, Genetics and Molecular Biology ,10211 Zurich-Basel Plant Science Center ,Selection, Genetic ,030304 developmental biology ,Changement climatique ,Genetic diversity ,business.industry ,Genetic Variation ,Molecular Sequence Annotation ,Digitaria exilis ,General Chemistry ,15. Life on land ,biology.organism_classification ,Amélioration des plantes ,030104 developmental biology ,Crop diversity ,13. Climate action ,General Biochemistry ,Africa ,lcsh:Q ,business ,Edible Grain ,030217 neurology & neurosurgery ,010606 plant biology & botany - Abstract
Sustainable food production in the context of climate change necessitates diversification of agriculture and a more efficient utilization of plant genetic resources. Fonio millet (Digitaria exilis) is an orphan African cereal crop with a great potential for dryland agriculture. Here, we establish high-quality genomic resources to facilitate fonio improvement through molecular breeding. These include a chromosome-scale reference assembly and deep re-sequencing of 183 cultivated and wild Digitaria accessions, enabling insights into genetic diversity, population structure, and domestication. Fonio diversity is shaped by climatic, geographic, and ethnolinguistic factors. Two genes associated with seed size and shattering showed signatures of selection. Most known domestication genes from other cereal models however have not experienced strong selection in fonio, providing direct targets to rapidly improve this crop for agriculture in hot and dry environments., Fonio millet is a fast growing orphan cereal crop with a great potential for dryland agriculture. Here, the authors report chromosome-scale reference genome assembly and population genomic resources to shed light on genetic diversity, population structure and domestication of fonio millet.
- Published
- 2020
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.