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Abstract The quasi-2-day wave (Q2DW) is a large temperature disturbance in the austral summer-time mesosphere. Its decay-phase movement and phase-speed are poorly understood. Q2DW events observed by the microwave limb sounder (MLS) onboard the NASA Aura satellite reveal that during the temperature Q2DW’s decay-phase, the Q2DW temperature disturbance is still substantial, but its phase-speed reduces exponentially, on average, from around −70 to −20 m/s in around 30-days. Observations also reveal significant interannual variability in these phase-speed values. Q2DW events simulated by the extended Canadian middle atmosphere model (eCMAM) reveal that during the Q2DW decay-phase, the temperature Q2DW phase-speed is strongly correlated with the summer mesosphere easterly jet (SMEJ) wind values. eCMAM also shows that the phase-speed interannual variabilities partially reflect the interannual variabilities of the SMEJ. Planetary-wave diagnostics indicate that during the Q2DW’s decay phase, there is still an active transfer of momentum from the SMEJ into Q2DW. The model simulations therefore indicate that the SMEJ plays a substantial role in the decaying temperature Q2DW phase-speed variabilities observed by MLS. This adds to our knowledge of how the SMEJ affects the Q2DW.

Polar mesospheric cloud (PMC) data obtained from the Aeronomy of Ice in the Mesosphere (AIM)/Cloud Imaging and Particle Size (CIPS) experiment and Himawari-8/Advanced Himawari Imager (AHI) observations are analyzed for multi-year climatology and interannual variations. Linkages between PMCs, mesospheric temperature, and water vapor (H2O) are further investigated with data from the Microwave Limb Sounder (MLS). Our analysis shows that PMC onset date and occurrence rate are strongly dependent on the atmospheric environment, i.e., the underlying seasonal behavior of temperature and water vapor. Upper-mesospheric dehydration by PMCs is evident in the MLS water vapor observations. The spatial patterns of the depleted water vapor correspond to the PMC occurrence region over the Arctic and Antarctic during the days after the summer solstice. The year-to-year variabilities in PMC occurrence rates and onset dates are highly correlated with mesospheric temperature and H2O. They show quasi-quadrennial oscillation (QQO) with 4–5-year periods, particularly in the southern hemisphere (SH). The combined influence of mesospheric cooling and the mesospheric H2O increase provides favorable conditions for PMC formation. The global increase in mesospheric H2O during the last decade may explain the increased PMC occurrence in the northern hemisphere (NH). Although mesospheric temperature and H2O exhibit a strong 11-year variation, little solar cycle signatures are found in the PMC occurrence during 2007–2021.

Fast atmospheric processes such as deep convection and severe storms are challenging to observe and understand without adequate spatiotemporal sampling. Geostationary (GEO) imaging has the advantage of tracking these fast processes continuously at a cadence of the 10 min global and 1 min mesoscale from thermal infrared (TIR) channels. More importantly, the newly-available GEO-GEO stereo observations from our 3D-Wind algorithm provide more accurate height assignment for atmospheric motion vectors (AMVs) than those from conventional TIR methods. Unlike the radiometric methods, the stereo height is insensitive to radiometric TIR calibration of satellite sensors and can assign the feature height correctly under complex situation (e.g., multi-layer clouds and atmospheric inversion). This paper shows a case study from continuous GEO-GEO stereo observations over the Eastern Pacific during 1–5 February 2023, to highlight diurnal variations of clouds and dynamics in the planetary boundary layer (PBL), altocumulus/congestus, convective outflow and tropical tropopause layer (TTL). Because of their good vertical resolution, the stereo observations often show a wind shear in these cloud layers. As an example, the stereo winds reveal the classic Ekman spiral in marine PBL dynamics with a clockwise (counterclockwise) wind direction change with height in the Northern (Southern) Hemisphere subtropics. Over the Southeastern Pacific, the stereo cloud observations show a clear diurnal variation in the closed-to-open cell transition in the PBL and evidence of precipitation at a lower level from broken stratocumulus clouds.

High-frequency skywave propagation can be heavily impacted by D- and E-region dynamics requiring accurate global measurements to optimize performance. A standard measurement technique is to use ionosondes, but they are unable to measure below 1 MHz and are only available at a limited number of land-locked sites around the globe. In contrast, the Global Navigation Satellite System radio occultation (GNSS-RO) bottom-up method is a new approach specifically designed to generate electron density profiles in the D- and E- region ionosphere. It takes advantage of satellite constellations that currently provide over 20,000 daily measurements and global coverage. In this paper, GNSS-RO profiles were compared against ionosonde profiles at four sites covering a wide latitudinal range, and FIRI modeled profiles corresponding to the same latitude and local solar time. This comparison was completed using daytime profiles when sporadic-E (Es) was not present. The average GNSS-RO profile is found to be a few kilometers higher in altitude than the ionosonde profiles at the minimum frequency, fmin. When the ionosonde profiles are shifted so that the altitudes match at fmin, they are in good agreement up to the E-region peak altitude, hmE. Below fmin, the GNSS-RO profile is in good agreement with the FIRI profile, indicating that the profiles can measure the D- to E- transition region. The frequency of the E-region peak, foE, showed general agreement between the GNSS-RO and ionosonde measurements; however, the hmE agreement was weaker and the GNSS-RO profiles tend to have an hmE in a narrow altitude range for all profiles. Virtual heights were simulated for the GNSS-RO profiles using a numerical ray tracer for direct comparison with ionosonde observations, which showed agreement for many of the virtual heights near fmin, but also indicated a positive bias in the GNSS-RO virtual heights that may be due to low foE or elevated hmE estimates. For a quiet ionosphere, the shifted GNSS-RO electron density profiles were a good match for both measured ionosonde profiles and modeled FIRI profiles and the method is capable of providing global coverage of the D- and E-regions. Future work will require more data for seasonal and morning–afternoon comparisons as well as comparisons for the disturbed ionosphere when the sporadic-E layer is present.

A growing number of SmallSat/CubeSat constellations with high-rate (50–100 Hz) global navigation satellite system radio occultations (GNSS-RO) as well as low-rate (1 Hz) precise orbit determination (GNSS-POD) limb-viewing capabilities provide unprecedented spatial and temporal sampling rates for ionospheric studies. In the F-region electron density (Ne) retrieval process, instead of the conventional onion-peeling (OP) inversion, an optimal estimation (OE) inversion technique was recently developed using total electron content measurements acquired by GNSS-POD link. The new technique is applied to data acquired from the COSMIC-1, COSMIC-2, and Spire constellations. Although both OE and OP techniques use the Abel weighting function in Ne inversion, OE significantly differs in its performance, especially in the lower F- and E-regions. In this work, we evaluate and compare newly derived data sets using F2 peak properties with other space-based and ground-based observations. We determine the F2 peak Ne (NmF2) and its altitude (hmF2), and compare them with the OP-retrieved values. Good agreement is observed between the two techniques for both NmF2 and hmF2. In addition, we also utilize autoscaled F2 peak measurements from a number of worldwide Digisonde stations (∼30). The diurnal sensitivity and latitudinal variability of the F2 peak between the two techniques are carefully studied at these locations. Good agreement is observed between OE-retrieved NmF2 and Digisonde-measured NmF2. However, significant differences appear between OE-retrieved hmF2 and Digisonde-measured hmF2. During the daytime, Digisonde-measured hmF2 remains ∼25–45 km below the OE-retrieved hmF2, especially at mid and high latitudes. We also incorporate F-region Ne measurements from two incoherent scatter radar observations at high latitudes, located in the North American (Millstone Hill) and European (EISCAT at Tromso) sectors. The radar measurements show good agreement with OE-retrieved values. Although there are several possible sources of error in the ionogram-derived Ne profiles, our further analysis on F1 and F2 layers indicates that the low Digisonde hmF2 is caused by the autoscaled method, which tends to detect a height systematically below the F2 peak when the F1 layer is present.

GNSS-LEO radio links from Precise Orbital Determination (POD) and Radio Occultation (RO) antennas have been used increasingly in characterizing the global 3D distribution and variability of ionospheric electron density (Ne). In this study, we developed an optimal estimation (OE) method to retrieve Ne profiles from the slant total electron content (hTEC) measurements acquired by the GNSS-POD links at negative elevation angles (ε < 0°). Although both OE and onion-peeling (OP) methods use the Abel weighting function in the Ne inversion, they are significantly different in terms of performance in the lower ionosphere. The new OE results can overcome the large Ne oscillations, sometimes negative values, seen in the OP retrievals in the E-region ionosphere. In the companion paper in this Special Issue, the HmF2 and NmF2 from the OE retrieval are validated against ground-based ionosondes and radar observations, showing generally good agreements in NmF2 from all sites. Nighttime hmF2 measurements tend to agree better than the daytime when the ionosonde heights tend to be slightly lower. The OE algorithm has been applied to all GNSS-POD data acquired from the COSMIC-1 (2006–2019), COSMIC-2 (2019–present), and Spire (2019–present) constellations, showing a consistent ionospheric Ne morphology. The unprecedented spatiotemporal sampling of the ionosphere from these constellations now allows a detailed analysis of the frequency–wavenumber spectra for the Ne variability at different heights. In the lower ionosphere (~150 km), we found significant spectral power in DE1, DW6, DW4, SW5, and SE4 wave components, in addition to well-known DW1, SW2, and DE3 waves. In the upper ionosphere (~450 km), additional wave components are still present, including DE4, DW4, DW6, SE4, and SW4. The co-existence of eastward- and westward-propagating wave4 components implies the presence of a stationary wave4 (SPW4), as suggested by other earlier studies. Further improvements to the OE method are proposed, including a tomographic inversion technique that leverages the asymmetric sampling about the tangent point associated with GNSS-LEO links.

In the original publication [...]

The stereo-winds method follows trackable atmospheric cloud features from multiple viewing perspectives over multiple times, generally involving multiple satellite platforms. Multi-temporal observations provide information about the wind velocity and the observed parallax between viewing perspectives provides information about the height. The stereo-winds method requires no prior assumptions about the thermal profile of the atmosphere to assign a wind height, since the height of the tracked feature is directly determined from the viewing geometry. The method is well developed for pairs of Geostationary (GEO) satellites and a GEO paired with a Low Earth Orbiting (LEO) satellite. However, neither GEO-GEO nor GEO-LEO configurations provide coverage of the poles. In this paper, we develop the stereo-winds method for multi-LEO configurations, to extend coverage from pole to pole. The most promising multi-LEO constellation studied consists of Terra/MODIS and Sentinel-3/SLSTR. Stereo-wind products are validated using clear-sky terrain measurements, spaceborne LiDAR, and reanalysis winds for winter and summer over both poles. Applications of multi-LEO polar stereo winds range from polar atmospheric circulation to nighttime cloud identification. Low cloud detection during polar nighttime is extremely challenging for satellite remote sensing. The stereo-winds method can improve polar cloud observations in otherwise challenging conditions.

Stereo tracking of clouds from multiple satellites permits the simultaneous retrieval of an atmospheric motion vector (“wind”) and its height in the atmosphere. The direct measurement of height is a major advantage of stereo methods over observations made from a single satellite where the height must be inferred from infrared brightness temperatures. A pair of operational geostationary satellites over the Americas provides stereo coverage where their two fields of view intersect. Stereo coverage can be extended to nearly a full hemisphere with a third satellite. We demonstrate this configuration with the operational GOES-R constellation of GOES-16 (east) and GOES-17 (west) augmented by GOES-18 in its central test slot and use the 500-m resolution Advanced Baseline Imager Band 2. We examine the consistency of the pairwise products created from GOES-18 and -16 versus GOES-18 and -17 and create a fused triple-GOES product that spans nearly the full hemisphere seen from GOES-18. We also examine the retrieval of ground points observed under clear skies and compare their retrievals to zero speed and known terrain heights. The results are compatible with a wind accuracy about 0.1 m/s with height assignment uncertainty of 175 m.

Precipitation type is a key parameter used for better retrieval of precipitation characteristics as well as to understand the cloud–convection–precipitation coupling processes. Ice crystals and water droplets inherently exhibit different characteristics in different precipitation regimes (e.g., convection, stratiform), which reflect on satellite remote sensing measurements that help us distinguish them. The Global Precipitation Measurement (GPM) Core Observatory’s microwave imager (GMI) and dual-frequency precipitation radar (DPR) together provide ample information on global precipitation characteristics. As an active sensor, the DPR provides an accurate precipitation type assignment, while passive sensors such as the GMI are traditionally only used for empirical understanding of precipitation regimes. Using collocated precipitation type flags from the DPR as the “truth”, this paper employs machine learning (ML) models to train and test the predictability and accuracy of using passive GMI-only observations together with ancillary information from a reanalysis and GMI surface emissivity retrieval products. Out of six ML models, four simple ones (support vector machine, neural network, random forest, and gradient boosting) and the 1-D convolutional neural network (CNN) model are identified to produce 90–94% prediction accuracy globally for five types of precipitation (convective, stratiform, mixture, no precipitation, and other precipitation), which is much more robust than previous similar effort. One novelty of this work is to introduce data augmentation (subsampling and bootstrapping) to handle extremely unbalanced samples in each category. A careful evaluation of the impact matrices demonstrates that the polarization difference (PD), brightness temperature (Tc) and surface emissivity at high-frequency channels dominate the decision process, which is consistent with the physical understanding of polarized microwave radiative transfer over different surface types, as well as in snow and liquid clouds with different microphysical properties. Furthermore, the view-angle dependency artifact that the DPR’s precipitation flag bears with does not propagate into the conical-viewing GMI retrievals. This work provides a new and promising way for future physics-based ML retrieval algorithm development.

Lack of instrument sensitivity to low electron density (Ne) concentration makes it difficult to measure sharp Ne vertical gradients (four orders of magnitude over 30 km) in the D/E-region. A robust algorithm is developed to retrieve global D/E-region Ne from the high-rate GNSS radio occultation (RO) data, to improve spatiotemporal coverage using recent SmallSat/CubeSat constellations. The new algorithm removes F-region contributions in the RO excess phase profile by fitting a linear function to the data below the D-region. The new GNSS-RO observations reveal many interesting features in the diurnal, seasonal, solar-cycle, and magnetic-field-dependent variations in the Ne morphology. While the D/E-region Ne is a function of solar zenith angle (χ), it exhibits strong latitudinal variations for the same χ with a distribution asymmetric about noon. In addition, large longitudinal variations are observed along the same magnetic field pitch angle. The summer midlatitude Ne and sporadic E (Es) show a distribution similar to each other. The distribution of auroral electron precipitation correlates better with the pitch angle from the magnetosphere than from one at 100 km. Finally, a new TEC retrieval technique is developed for the high-rate RO data with a top reaching at least 120 km. For better characterization of the E- to F-transition in Ne and more accurate TEC retrievals, it is recommended to have all GNSS-RO acquisition routinely up to 220 km.

The Compact Midwave Imaging System (CMIS) is a wide field of view, multi-angle, multi-spectral pushframe imager that relies on the forward motion of the satellite to create a two-dimensional (2D) image swath. An airborne demonstration of CMIS was successfully completed in January–February 2021 on the NASA Langley Research Center Gulfstream III. The primary objective of the four-flight campaign was to demonstrate the capability of this unique instrument to perform stereo observations of clouds and other particulates (e.g., smoke) in the atmosphere. It is shown that the midwave infrared (MWIR) spectral bands of CMIS provide a unique 24/7 capability with high resolution for accurate stereo sensing. The instrument relies on new focal plane array (FPA) technology, which provides excellent sensitivity at much warmer detector temperatures than traditional technologies. This capability enabled a compact, low-cost design that can provide atmospheric motion vectors and cloud heights to support requirements for atmospheric winds in the 2017–2027 Earth Science Decadal Survey. Applications include day/night observations of the planetary boundary layer, severe weather, and wildfires. A comparison with current space-based earth science instruments demonstrates that the SWIR/MWIR multi-spectral capability of CMIS is competitive with larger, more expensive instrumentation. Imagery obtained over a controlled burn and operating nuclear power plant demonstrated the sensitivity of the instrument to temperature variations. The system relies on a mature stereoscopic imaging technique applied to the same scene from two independent platforms to unambiguously retrieve atmospheric motion vectors (AMVs) with accurate height assignment. This capability has been successfully applied to geostationary and low-earth orbit satellites to achieve excellent accuracy. When applied to a ground-point validation case, the accuracy for the CMIS aircraft observations was 20 m and 0.3 m/s for cloud heights and motion vectors, respectively. This result was confirmed by a detailed error analysis with analytical and covariance models. The results for CMIS cases with underflights of Aeolus, CALIPSO, and Aqua provided a good validation of expected accuracies. The paper also showed the feasibility of accommodating CMIS on CubeSats to enable multiple instruments to be flown in a leader–follower mode.

Reflected shortwave (SW) solar radiations at the top of atmosphere from Clouds and the Earth’s Radiant Energy System (CERES), Modern Era-Retrospective analysis for Research and Applications version 2 (MERRA-2), and ECMWF Reanalysis 5th Generation (ERA5) are examined to better understand their differences in spatial and temporal variations (seasonal and diurnal cycle timescale) with respect to the observations from the Earth Polychromatic Imaging Camera (EPIC) on the Deep Space Climate Observatory (DSCOVR) satellite. Comparisons between two reanalyses (MERRA-2 and ERA5) and EPIC reveal that MERRA-2 has a generally larger deviation from EPIC than ERA5 in terms of the SW radiance and diurnal variability in all seasons, which can be attributed to larger cloud biases in MERRA-2. MERRA-2 produces more ice/liquid water content than ERA5 over the tropical warm pool, leading to positive SW biases in cloud and radiance, while both reanalyses underestimate the observed SW radiance from EPIC in the stratus-topped region off the western coast of US/Mexico in the boreal summer. Himalaya/Tibet region in the boreal spring/summer and the midlatitude Southern Hemisphere in the boreal winter are the regions where MERRA-2 and ERA5 deviate largely from EPIC, but their deviations have the opposite sign. Vertical structures of cloud ice/liquid water content explain reasonably well these contrasting differences between the two reanalyses. As two independent observations, CERES and EPIC agree well with each other in terms of the SW radiance maps, showing 2–3% mean absolute errors over the tropical midlatitudes. The CERES-EPIC consistency further confirms that the reanalyses still have challenges in representing the SW flux and its global distribution. In the CERES-EPIC observation differences, CERES slightly overestimates the diurnal cycle (as a function of local solar time) of the observed EPIC irradiance in the morning and underestimates it in the afternoon, while the opposite is the case in the reanalyses.

The demonstration of a newly developed compact thermal imager (CTI) on the International Space Station (ISS) has provided not only a technology advancement but a rich high-resolution dataset on global clouds, atmospheric and land emissions. This study showed that the free-running CTI instrument could be calibrated to produce scientifically useful radiance imagery of the atmosphere, clouds, and surfaces with a vertical resolution of ~460 m at limb and a horizontal resolution of ~80 m at nadir. The new detector demonstrated an excellent sensitivity to detect the weak limb radiance perturbations modulated by small-scale atmospheric gravity waves. The CTI’s high-resolution imaging was used to infer vertical cloud temperature profiles from a side-viewing geometry. For nadir imaging, the combined high-resolution and high-sensitivity capabilities allowed the CTI to better separate cloud and surface emissions, including those in the planetary boundary layer (PBL) that had small contrast against the background surface. Finally, based on the ISS’s orbit, the stable detector performance and robust calibration algorithm produced valuable diurnal observations of cloud and surface emissions with respect to solar local time during May–October 2019, when the CTI had nearly continuous operation.

Height assignment is an important problem for satellite measurements of atmospheric motion vectors (AMVs) that are interpreted as winds by forecast and assimilation systems. Stereo methods assign heights to AMVs from the parallax observed between observations from different vantage points in orbit while tracking cloud or moisture features. In this paper, we fully develop the stereo method to jointly retrieve wind vectors with their geometric heights from geostationary satellite pairs. Synchronization of observations between observing systems is not required. NASA and NOAA stereo-winds codes have implemented this method and we processed large datasets from GOES-16, -17, and Himawari-8. Our retrievals are validated against rawinsonde observations and demonstrate the potential to improve the forecast skill. Stereo winds also offer an important mitigation for the loop heat pipe anomaly on GOES-17 during times when warm focal plane temperatures cause infrared channels that are needed for operational height assignments to fail. We also examine several application areas, including deep convection in tropical cyclones, planetary boundary layer dynamics, and fire smoke plumes, where stereo methods provide insights into atmospheric processes. The stereo method is broadly applicable across the geostationary ring where systems offering similar image navigation and registration (INR) performance as GOES-R are deployed.

Ionospheric scintillation can significantly degrade the performance and the usability of space-based communication and navigation signals. Characterization and prediction of ionospheric scintillation can be made from the Global Navigation Satellite System (GNSS) radio occultation (RO) technique using the measurement from a deep slant path where the RO tangent height (ht) is far below the ionospheric sources. In this study, the L–band S4 from the RO measurements at ht = 30 km is used to infer the amplitude scintillation on the ground. The analysis of global RO data at ht = 30 km shows that sporadic–E (Es), equatorial plasma bubbles (EPBs), and equatorial spread–F (ESF) produce most of the significant S4 enhancements, although the polar S4 is generally weak. The enhanced S4 is a strong function of local time and magnetic dip angle. The Es–induced daytime S4 tends to have a negative correlation with the solar cycle at low latitudes but a positive correlation at high latitudes. The nighttime S4 is dominated by a strong semiannual variation at low latitudes.

Black-sky cloud albedo (BCA) is derived from satellite UV 340 nm observations from NOAA and NASA satellites to infer long-term (1980–2018) shortwave cloud albedo variations induced by volcano eruptions, the El Niño–Southern Oscillation, and decadal warming. While the UV cloud albedo has shown no long-term trend since 1980, there are statistically significant reductions over the North Atlantic and over the marine stratocumulus decks off the coast of California; increases in cloud albedo can be seen over Southeast Asia and over cloud decks off the coast of South America. The derived BCA assumes a C-1 water cloud model with varying cloud optical depths and a Cox–Munk surface BRDF over the ocean, using radiances calibrated over the East Antarctic Plateau and Greenland ice sheets during summer.

Recent changes in Earth’s climate system have significantly affected the radiation budget and its year-to-year variations at top of the atmosphere (TOA). Observing high-latitude TOA fluxes is still challenging from space, because spatial inhomogeneity of surface/atmospheric radiative processes and spectral variability can reflect sunlight very differently. In this study we analyze the 20-year TOA flux and albedo data from CERES and MISR over the Arctic, the Antarctic, and Tibetan Plateau (TP), and found overall great consistency in the TOA albedo trend and interannual variations. The observations reveal a lagged correlation between the Arctic and subarctic albedo fluctuations. The observed year-to-year variations are further used to evaluate the reanalysis data, which exhibit substantial shortcomings in representing the polar TOA flux variability. The observed Arctic flux variations are highly correlated with cloud fraction (CF), except in the regions where CF > 90% or where the surface is covered by ice. An empirical orthogonal function (EOF) analysis shows that the first five EOFs can account for ~50% of the Arctic TOA variance, whereas the correlation with climate indices suggests that Sea Ice Extent (SIE), North Atlantic Oscillation (NAO) and 55°N–65°N cloudiness are the most influential processes in driving the TOA flux variabilities.

A continuous record of direct total solar irradiance (TSI) observations began with a series of satellite experiments in 1978. This record requires comparisons of overlapping satellite observations with adequate relative precisions to provide useful long term TSI trend information. Herein we briefly review the active cavity radiometer irradiance monitor physikalisch-meteorologisches observatorium davos (ACRIM-PMOD) TSI composite controversy regarding how the total solar irradiance (TSI) has evolved since 1978 and about whether TSI significantly increased or slightly decreased from 1980 to 2000. The main question is whether TSI increased or decreased during the so-called ACRIM-gap period from 1989 to 1992. There is significant discrepancy between TSI proxy models and observations before and after the gap, which requires a careful revisit of the data analysis and modeling performed during the ACRIM-gap period. In this study, we use three recently proposed TSI proxy models that do not present any TSI increase during the ACRIM-gap, and show that they agree with the TSI data only from 1996 to 2016. However, these same models significantly diverge from the observations from 1981 and 1996. Thus, the scaling errors must be different between the two periods, which suggests errors in these models. By adjusting the TSI proxy models to agree with the data patterns before and after the ACRIM-gap, we found that these models miss a slowly varying TSI component. The adjusted models suggest that the quiet solar luminosity increased from the 1986 to the 1996 TSI minimum by about 0.45 W/m2 reaching a peak near 2000 and decreased by about 0.15 W/m2 from the 1996 to the 2008 TSI cycle minimum. This pattern is found to be compatible with the ACRIM TSI composite and confirms the ACRIM TSI increasing trend from 1980 to 2000, followed by a long-term decreasing trend since.

Atmospheric motion vectors (AMVs), derived by tracking patterns, represent the winds in a layer characteristic of the pattern. AMV height (or pressure), important for applications in atmospheric research and operational meteorology, is usually assigned using observed IR brightness temperatures with a modeled atmosphere and can be inaccurate. Stereoscopic tracking provides a direct geometric height measurement of the pattern that an AMV represents. We extend our previous work with multi-angle imaging spectro−radiometer (MISR) and GOES to moderate resolution imaging spectroradiometer (MODIS) and the GOES-R series advanced baseline imager (ABI). MISR is a unique satellite instrument for stereoscopy with nine angular views along track, but its images have a narrow (380 km) swath and no thermal IR channels. MODIS provides a much wider (2330 km) swath and eight thermal IR channels that pair well with all but two ABI channels, offering a rich set of potential applications. Given the similarities between MODIS and VIIRS, our methods should also yield similar performance with VIIRS. Our methods, as enabled by advanced sensors like MODIS and ABI, require high-accuracy geographic registration in both systems but no synchronization of observations. AMVs are retrieved jointly with their heights from the disparities between triplets of ABI scenes and the paired MODIS granule. We validate our retrievals against MISR-GOES retrievals, operational GOES wind products, and by tracking clear-sky terrain. We demonstrate that the 3D-wind algorithm can produce high-quality AMV and height measurements for applications from the planetary boundary layer (PBL) to the upper troposphere, including cold-air outbreaks, wildfire smoke plumes, and hurricanes.

The 16-year MISR monthly radiances are analyzed in this study, showing significant enhancements of anisotropic scattering at high latitudes after several major volcanic eruptions with injection heights greater than 14 km. The anomaly of deseasonalized radiance anisotropy between MISR’s DF and DA views (70.5° forward and aft) is largest in the blue band with amplitudes amounting to 5–15% of the mean radiance. The anomalous radiance anisotropy is a manifestation of the stronger forward scattering of reflected sunlight due to the direct and indirect effects of stratospheric volcanic aerosols (SVAs). The perturbations of MISR radiance anisotropy from the Kasatochi (August 2008), Sarychev (June 2009), Nabro (June 2011) and Calbuco (April 2015) eruptions are consistent with the poleward transported SVAs observed by CALIOP and OMPS-LP. In a particular scene over the Arctic Ocean, the stratospheric aerosol mid-visible optical depth can reach as high as 0.2–0.5. The enhanced global forward scattering by SVAs has important implications for the shortwave radiation budget.

Global wind observations are fundamental for studying weather and climate dynamics and for operational forecasting. Most wind measurements come from atmospheric motion vectors (AMVs) by tracking the displacement of cloud or water vapor features. These AMVs generally rely on thermal infrared (IR) techniques for their height assignments, which are subject to large uncertainties in the presence of weak or reversed vertical temperature gradients near the planetary boundary layer (PBL) and tropopause folds. Stereo imaging can overcome the height assignment problem using geometric parallax for feature height determination. In this study we develop a stereo 3D-Wind algorithm to simultaneously retrieve AMV and height from geostationary (GEO) and low Earth orbit (LEO) satellite imagery and apply it to collocated Geostationary Operational Environmental Satellite (GOES) and Multi-angle Imaging SpectroRadiometer (MISR) imagery. The new algorithm improves AMV and height relative to products from GOES or MISR alone, with an estimated accuracy of

Abstract The negative inference that consumers hold ‘eavesdropping’ views concerning the intelligent recommendation services of digital platforms is fostering their selective exposure to information that aligns with their preferred viewpoints. This, in turn, exacerbates their psychological defense against digital platforms, causing consumers to become more prone to verifying existing beliefs and fostering the polarization of information choices. This phenomenon directly impacts the effectiveness of smart recommendations and the accuracy of digital platforms’ predictions of consumer behavior, potentially even adversely affecting brand trust and the long-term stability of platform usage. From the perspectives of self-verification and cognitive closure, this study delves into the influence of ‘eavesdropping’ inference cues within intelligent recommendation systems on consumers’ selective exposure to information and the underlying psychological mechanisms. Experimental findings indicated: (1) Behavioral results showed that consumers who believed in eavesdropping by digital platforms, under conditions of high comprehensibility, were more inclined to selectively engage with consistent information as opposed to inconsistent information. Under conditions of low comprehensibility, however, information consistency had no significant effect on consumers’ selective exposure. (2) EEG results revealed that, based on the need for cognitive closure, individuals in the high comprehensibility group, during the self-verification process, exhibited more cognitive conflict and required greater cognitive effort when presented with inconsistent information compared to those in the consistent information group. This, in turn, elicited higher N2 and N450 amplitudes. This study uncovered the psychological mechanism underlying this phenomenon. When consumers developed a skeptical perspective on perceived eavesdropping by digital platforms within intelligent recommendation systems, they promptly engaged in self-verification, driven by the need for cognitive closure. The study’s findings offered practical guidance to digital platforms on how to alleviate consumer suspicions when designing intelligent recommendation services, thereby mitigating negative consumer reactions to the perception of ‘eavesdropping’. This insight held significant theoretical and practical value at the intersection of digital marketing and psychology.

Abstract Photocatalytic oxidative coupling of methane with oxygen is promising to obtain valuable muti-carbon products, yet suffering low reactivity. Here, we apply cerium modifications on zinc oxide-supported gold catalysts based on the electronic asymmetry design of lattice oxygen to improve the coupling activity. The methane conversion rate exceeds 16000 μmol g−1 h−1 with muti-carbon selectivity of 94.9% and catalytic durability of 3 days, and it can increase to 34000 μmol g−1 h−1 under more thermal assistance, with a turnover frequency of 507 h−1 for ethane and an apparent quantum efficiency of 33.7% at 350 nm. According to systematic characterizations and theoretical analysis, cerium dopants not only can boost the formation of reactive oxygen species but also intervene in the vivacity of lattice oxygen by manipulating metal-oxygen bond strength, thereby leading to favorable methyl desorption to form ethane and quick water release. This work provides insight into the rational design of efficient photocatalysts for aerobic methane-to-ethane conversion.

Abstract Economic growth has brought about escalating environmental challenges. The purist of socioeconomic and environmental coordination necessitates a deep understanding of their interplay. Therefore, a game theory stepwise-cluster factorial coupling coordination model (GSFCM) has been developed to investigate the spatial and temporal patterns and driving forces of socioeconomic and environmental coordination in the Yangtze River Delta Region. Results reveal an upward in socioeconomic and environmental status from 2015 to 2020. All 41 cities in the region show progress towards coordination, coupled with spatial inequalities. Hangzhou, Shanghai, and Zhoushan demonstrate the highest coupling coordination degree (CCD), while Bozhou, Suzhou, and Fuyang located in Anhui exhibit the lowest levels. Socioeconomic factors contribute 82.98% to the enhancement of CCD, environmental factors contribute 11.05%, and their interaction accounts for 5.92%. Main drivers influencing CCD include Gross Domestic Product (GDP) per capita, the proportion of the added value of tertiary industry, PM2.5 concentration, and their interactions. Policy related to regional collaboration, industrial upgrades, and investment in environmental infrastructure are recomended to achieve a harmonious balance between economic growth and environmental protection. These insights are expected to support policy decisions in sustainable development of the region.

Abstract The air traffic information network is fundamental for ensuring the efficient and safe operation of flights. However, with the increasing demands of air traffic services, the rigidity of the traditional air traffic information network has become increasingly pronounced. Network function virtualization (NFV) technology presents an effective solution to address this issue. Within the NFV environment, the deployment of service function chains (SFC) forms the basis for achieving end-to-end air traffic services. This paper addresses the low delay and high security requirements inherent in air traffic services and proposes an efficient and secure SFC deployment for delay optimization (ESSFCD-DO) method. Primarily, the paper conducts a theoretical analysis of SFC deployment, and derives four key principles related to SFC delay, security, and resource cost. Subsequently, based on these principles, the ESSFCD-DO method is developed, which encompasses the virtual network function (VNF) aggregation algorithm for security and resources cost optimization (VNFAA-SRCO), the VNF deployment algorithm based on topology aware (VNFD-TA), and the algorithm for deploying virtual links based on k-shortest path. Experimental results demonstrate that, in comparison to other SFC deployment methods within this domain, ESSFCD-DO achieves significant optimizations in terms of end-to-end delay of SFC and long-term revenue-cost ratio, while ensuring security and service request acceptance rate.

Abstract Compared with the general urban rail transit, some of the current rapid urban rail transit can reach a maximum speed of 140 km/h when the train is running, which exceeds the speed level of the general urban rail transit. To consider the influence of different speeds and loads on the vibration of viaducts and the surrounding soil environment, this paper establishes a three-dimensional finite element model of rail-viaduct soil. The results show that: the frequency domain acceleration of each measurement point increases with the increase of train speed; except for the measurement point which is 20 m away from the centerline of the track, the frequency domain speed of each measurement point increases with the increase of train speed; the frequency domain speed under the low-frequency component of the viaduct measurement point increases with the increase of train loading, and the growth rate is obviously larger than that of the middle and high frequency bands, and the frequency domain speed of the measurement points in the site also increases with the increase of train loading, and the growth rate of the low-frequency band is obviously larger than that of the middle and high frequency bands. The frequency domain velocity at each measurement point of the site also increases with the increase of train load, and the growth rate of the low-frequency band is obviously larger than that of the middle and high-frequency bands.

Abstract Efficient catalysts are imperative to accelerate the slow oxygen reaction kinetics for the development of emerging electrochemical energy systems ranging from room-temperature alkaline water electrolysis to high-temperature ceramic fuel cells. In this work, we reveal the role of cationic inductive interactions in predetermining the oxygen vacancy concentrations of 235 cobalt-based and 200 iron-based perovskite catalysts at different temperatures, and this trend can be well predicted from machine learning techniques based on the cationic lattice environment, requiring no heavy computational and experimental inputs. Our results further show that the catalytic activity of the perovskites is strongly correlated with their oxygen vacancy concentration and operating temperatures. We then provide a machine learning-guided route for developing oxygen electrocatalysts suitable for operation at different temperatures with time efficiency and good prediction accuracy.

Abstract Coal and gas outbursts, along with rock bursts, are common dynamic disasters in coal mining, threatening the safety and green production of coal mines. The distribution of coal seam stress is an external factor contributing to coal mine power disasters. The drainage of confined water in coal seam roof is the primary factor of coal seam stress changes. Using theoretical analysis and numerical simulations, the influence of roof confined water on coal seam stress by looking at the law of stress and stress conservation transfer in the drainage layer is investigated. Our results show that: (1) after drainage, there is an increase in the local stress within the coal seam, with a stress concentration factor of 1.35. The influence range of theoretically calculated stress is consistent with the measured results. (2) the maximum value of drainage boundary stress correlated positively with the angle of the water-rich abnormal area, with a linear fitting of R2 = 0.98. These findings hold significant theoretical and practical implications for preventing and controlling dynamic disasters during the mining of water-rich coal seams.

Abstract The kagome lattice is a versatile platform for investigating correlated electronic states. However, its realization in two-dimensional (2D) semiconductors for tunable device applications is still challenging. An alternative strategy to create kagome-like bands is to realize a coloring-triangle (CT) lattice in semiconductors through a distortion of a modified triangular lattice. Here, we report the observation of low-energy kagome-like bands in a semiconducting 2D transition metal chalcogenide—Cr8Se12 with a thickness of 7 atomic layers—which exhibits a CT lattice and a bandgap of 0.8 eV. The Cr-deficient layer beneath the topmost Se-full layer is partially occupied with 2/3 occupancy, yielding a √3 × √3 Cr honeycomb network. Angle-resolved photoemission spectroscopy measurements and first-principles investigations reveal the surface kagome-like bands near the valence band maximum, which are attributed to topmost Se p z orbitals modulated by the honeycomb Cr.

Abstract Green consumption is a crucial pathway towards achieving global sustainability goals. Product-oriented green advertisements can effectively stimulate consumers’ latent needs and convert them into eventual purchasing intentions and behaviors, thereby promoting green consumption. Given that neuromarketing methods facilitate the understanding of consumers’ decision-making processes, this study combines prospect theory and need fulfillment theory, employing event-related potentials (ERPs) as measures to explore changes in consumers’ cognitive resources and emotional arousal levels when confronted with green products and advertising information. This enables inference regarding consumers’ acceptance of purchasing and their psychological processes. Behavioral results indicated that message framing influences consumers’ purchases, with consumers consuming more green in response to negatively framed advertisements. EEG results indicated that matching positive framing with utilitarian green products was effective in increasing consumers’ cognitive attention in the early cognitive stage. In the late stage of cognition negative frames stimulated consumers’ mood swings more, and the influence of product type depended on the role of message frames, and the consumption motivation induced by the product, whose influence was overridden by external evaluations such as message frames. These research findings provide an explanation for the impact of frame information on consumers’ purchasing decisions at different stages, assisting marketers in devising diverse promotional strategies based on product characteristics to foster the development and practice of green consumption. This will further embed the concept of green consumption advocated by organizations such as the United Nations Environment Programme (UNEP), World Wildlife Fund (WWF), and Greenpeace into the public consciousness.

Abstract In various countries worldwide, the incidence of colon cancer-related deaths has been on the rise in recent years. Early detection of symptoms and identification of intestinal polyps are crucial for improving the cure rate of colon cancer patients. Automated computer-aided diagnosis (CAD) has emerged as a solution to the low efficiency of traditional methods relying on manual diagnosis by physicians. Deep learning is the latest direction of CAD development and has shown promise for colonoscopic polyp segmentation. In this paper, we present a multi-level encoder-decoder architecture for polyp segmentation based on the Transformer architecture, termed NA-SegFormer. To improve the performance of existing Transformer-based segmentation algorithms for edge segmentation on colon polyps, we propose a patch merging module with a neighbor attention mechanism based on overlap patch merging. Since colon tract polyps vary greatly in size and different datasets have different sample sizes, we used a unified focal loss to solve the problem of category imbalance in colon tract polyp data. To assess the effectiveness of our proposed method, we utilized video capsule endoscopy and typical colonoscopy polyp datasets, as well as a dataset containing surgical equipment. On the datasets Kvasir-SEG, Kvasir-Instrument and KvasirCapsule-SEG, the Dice score of our proposed model reached 94.30%, 94.59% and 82.73%, with an accuracy of 98.26%, 99.02% and 81.84% respectively. The proposed method achieved inference speed with an Frame-per-second (FPS) of 125.01. The results demonstrated that our suggested model effectively segmented polyps better than several well-known and latest models. In addition, the proposed method has advantages in trade-off between inference speed and accuracy, and it will be of great significance to real-time colonoscopic polyp segmentation. The code is available at https://github.com/promisedong/NAFormer .

Abstract In a multicenter case–control investigation, we assessed the efficacy of the Electrooculogram Signal Analysis (EOG-SA) method, which integrates attention-related visual evocation, electrooculography, and nonlinear analysis, for distinguishing between intellectual and developmental disabilities (IDD) and typical development (TD) in children. Analyzing 127 participants (63 IDD, 64 TD), we applied nonlinear dynamics for feature extraction. Results indicated EOG-SA’s capability to distinguish IDD, with higher template thresholds and Correlation Dimension values correlating with clinical severity. The template threshold proved a robust indicator, with higher values denoting severe IDD. Discriminative metrics showed areas under the curve of 0.91 (template threshold) and 0.85/0.91 (D2), with sensitivities and specificities of 77.6%/95.9% and 93.5%/71.0%, respectively. EOG-SA emerges as a promising tool, offering interpretable neural biomarkers for early and nuanced diagnosis of IDD.

Abstract Previous studies typically assumed a constant total organic carbon (OC) storage in the lake water column, neglecting its significant variability within a changing world. Based on extensive field data and satellite monitoring techniques, we demonstrate considerable spatiotemporal variability in OC concentration and storage for 24,366 Chinese lakes during 1984–2023. Here we show that dissolved OC concentration is high in northwest saline lakes and particulate OC concentration is high in southeast eutrophic lakes. Along with increasing OC concentration and water volume, dissolved and particulate OC storage increase by 44.6% and 33.5%, respectively. Intensified human activities, water input, and wind disturbance are the key drivers for increasing OC storage. Moreover, higher OC storage further leads to an 11.0% increase in nationwide OC burial and a decrease in carbon emissions from 71.1% of northwest lakes. Similar changes are occurring globally, which suggests that lakes are playing an increasingly important role in carbon sequestration.

Abstract Discinaceae holds significant importance within the Pezizales, representing a prominent group of macroascomycetes distributed globally. However, there is a dearth of genomic studies focusing on this family, resulting in gaps in our understanding of its evolution, development, and ecology. Here we utilized state-of-the-art genome assembly methodologies, incorporating third-generation single-molecule fluorescence and Hi-C-assisted methods, to elucidate the genomic landscapes of Gyromitra esculenta and Paragyromitra xinjiangensis. The genome sizes of two species were determined to be 47.10 Mb and 48.20 Mb, with 23 and 22 scaffolds, respectively. 10,438 and 11,469 coding proteins were identified, with functional annotations encompassing over 96.47% and 94.40%, respectively. Assessment of completeness using BUSCO revealed that 98.71% and 98.89% of the conserved proteins were identified. The application of comparative genomic technology has helped in identifying traits associated with of heterothallic life cycle traits and elucidating unique patterns of chromosomal evolution. Additionally, we identified potential saprotrophic nutritional modes and systematic phylogenetic relationships between the two species. Therefore, this study provides crucial genomic insights into the evolution, nutritional type, and ecological roles of species within the Pezizales.

Abstract The aim of this study was to investigate the effect of zoledronic acid (ZA) on postoperative healing and functional rehabilitation in osteoporotic patients with rotator cuff (RC) injury. 96 Patients were divided into three groups according to bone mineral density and ZA use (Group A: normal BMD; Group B: osteoporosis and intravenous ZA use; Group C: osteoporosis, without ZA use). Radiologic, functional and Serological outcomes were evaluated 6 months after surgery. The functional scores in all groups exhibited significant improvement 6 months after surgery. Inter-group comparison showed that Constant Shoulder joint function Score (CSS) of group A not significantly differing from that of group B, the other indicators were significantly better than those of group B and C. There were no significant differences in shoulder forward flexion, abductive Range of Motion between group B and C. Other indicators of group B were significantly improved compared to group C. The retear rate in group C (30.3%, 10/33) was higher than group A (6.1%, 2/33) and group B (13.3%, 4/30). In conclusion, the application of ZA can significantly reduce the rate of RC retear in elderly patients with osteoporosis after surgery, which is significant for postoperative shoulder joint functional rehabilitation.

From an industry perspective, the past decade has been a whirlwind of innovation in automotive light detection and ranging (LiDAR). Numerous laser technologies and system solutions have been fiercely competing for market share. However, recent trends suggest a growing convergence on vertical-cavity surface-emitting laser (VCSEL) and antireflective VCSEL (AR-VCSEL) based solutions. This commentary, rooted in the practical realities of the industry, examines the historical trajectory of industrial laser technology for commercial automotive LiDAR. It specifically focuses on the recent applications of VCSEL/AR-VCSEL technologies and their future prospects.

Abstract To investigate the vibration isolation effect of composite vibration isolation walls on surface vibrations in suburban railway deep tunnels under various influencing factors, an integrated numerical model of the train was initially developed. This model solved the wheel-rail interaction force and was applied to a three-dimensional volume coupling model of the track soil. Subsequently, the model's reliability was validated through comparison with measured data. Afterward, the vibration isolation effects of various types of EPS material vibration isolation walls were examined, with a focus on exploring the impact of thickness, material proportion, and relative positioning of the materials within the vibration isolation wall composed of EPS material and concrete. Research indicates that with an increase in the burial depth of a single material vibration isolation wall, its effective vibration isolation frequency range gradually widens. When the burial depth of the vibration isolation wall exceeds the tunnel burial depth, the vibration isolation effect is optimal. Composite vibration isolation walls, with thicknesses smaller than single-material vibration isolation walls, exhibit superior vibration isolation effects compared to their single-material counterparts. The effective vibration isolation frequency band of composite vibration isolation walls differs from that of single-material vibration isolation walls. Using the optimal-size vibration isolation wall of a single material as a composite vibration isolation wall enhances the vibration isolation effect of peak acceleration in the frequency domain by 16.58% and peak velocity by 16.95%. Moreover, frequency domain peak displacement experiences a 30.73% improvement in the vibration isolation effect.

Abstract In rats with unilateral nephrectomy and cardiac dysfunction, renal function deteriorates at an accelerated rate, as evidenced by increased proteinuria. Whether myocardial infarct-induced heart failure (HF) exacerbates renal injury in hypertensive rats with mild renal injury has not been reported. Rats underwent either coronary ligation or sham surgery. Thirty spontaneously hypertensive rats (SHRs) aged 8 weeks were randomly divided into two groups. Group 1 was the sham group, in which the rats underwent thoracotomy without ligation of the coronary artery. Group 2 underwent coronary artery ligation. The rats in group 2 underwent coronary artery ligation on week 0. The experiment lasted 12 weeks. Urine was collected in metabolic cages over a 24-h period. Urine was collected from the rats 2 days before the end of the experiment, and the ratio of urinary protein to urinary creatinine was measured in the clinical laboratory. All rats were examined by echocardiogram one day before the end of the experiment. On the last day of the experiment, blood was collected and sent to the laboratory for analysis. Hematoxylin–eosin (HE) and periodic acid-Schiff (PAS) staining were performed on heart and kidney sections. The ejection fraction in group 2 was lower than that in group 1 (P

Abstract Aortic valve replacement (AVR) is a critical procedure for patients with aortic valve diseases. This study compares the effectiveness of three minimally-invasive surgical approaches for AVR: totally thoracoscopic (TT), right anterior mini-thoracotomy, and upper mini-sternotomy. We analyzed retrospective data from 130 patients who underwent one of these surgeries, focusing on various factors such as duration of hospital stay, operation time, times for cardiopulmonary bypass and aortic cross-clamping, postoperative complications, levels of cardiac biomarkers, pain intensity using the Visual Analog Scale, and mid-term survival rates. Results show that while the TT method had the longest operation times, it also had the shortest hospital stays and faster pain reduction post-surgery. Although the TT group initially showed higher cardiac biomarker levels after surgery, these levels normalized by the third day, similar to the other groups. There were no significant differences in mid-term survival and major adverse cardiac and cerebrovascular event (MACCE) rates among the groups. These findings suggest that the TT method, despite longer surgical times, offers a quicker initial recovery, making it a viable option for AVR.

Abstract Cell fate decisions remain poorly understood at the molecular level. Embryogenesis provides a unique opportunity to analyze molecular details associated with cell fate decisions. Works based on model organisms have provided a conceptual framework of genes that specify cell fate control, for example, transcription factors (TFs) controlling processes from pluripotency to immunity1. How TFs specify cell fate remains poorly understood. Here we report that SALL4 relies on NuRD (nucleosome-remodeling and deacetylase complex) to interpret BMP4 signal and decide cell fate in a well-controlled in vitro system. While NuRD complex cooperates with SALL4 to convert mouse embryonic fibroblasts or MEFs to pluripotency, BMP4 diverts the same process to an alternative fate, PrE (primitive endoderm). Mechanistically, BMP4 signals the dissociation of SALL4 from NuRD physically to establish a gene regulatory network for PrE. Our results provide a conceptual framework to explore the rich landscapes of cell fate choices intrinsic to development in higher organisms involving morphogen-TF-chromatin modifier pathways.

Abstract Cell fate is likely regulated by a common machinery, while components of this machine remain to be identified. Here we report the design and testing of engineered cell fate controller NanogBiD, fusing BiD or BRG1 interacting domain of SS18 with Nanog. NanogBiD promotes mouse somatic cell reprogramming efficiently in contrast to the ineffective native protein under multiple testing conditions. Mechanistic studies further reveal that it facilitates cell fate transition by recruiting the intended Brg/Brahma-associated factor (BAF) complex to modulate chromatin accessibility and reorganize cell state specific enhancers known to be occupied by canonical Nanog, resulting in precocious activation of multiple genes including Sall4, miR-302, Dppa5a and Sox15 towards pluripotency. Although we have yet to test our approach in other species, our findings suggest that engineered chromatin regulators may provide much needed tools to engineer cell fate in the cells as drugs era.

Abstract Intravenous immunoglobulin (IVIG) resistance in Kawasaki disease (KD) was associated with coronary artery lesions. Neutrophil percentage-to-albumin ratio (NPAR) is an index of mortality in several inflammatory diseases. This study focused on the association of NPAR with IVIG- resistance in KD. Clinical and laboratory data of 438 children with KD before IVIG treatment were retrospectively analyzed. Notably, high NPAR was associated with older age, high WBC, NP, ALT, total bilirubin and CRP, as well as with high the incidence of IVIG-resistance, and with low hemoglobin (Hb), PLT, ALB and sodium levels. NPAR (OR: 2.366, 95% CI: 1.46–3.897, p = 0.001) and Hb (OR: 0.967, 95% CI: 0.944–0.989, p = 0.004) were independent risk factors for IVIG-resistance. NPAR showed linear relation with IVIG-resistance (p for nonlinear = 0.711) and the nonlinear correlation was found between IVIG-resistance and Hb (p for nonlinear = 0.002). The predictive performance of NPAR was superior to Beijing model (z = 2.193, p = 0.028), and not inferior to Chongqing model (z = 0.983, p = 0.326) and the combination of NPAR and Hb (z = 1.912, p = 0.056). These findings revealed that NPAR is a reliable predictor of IVIG-resistance.

Abstract Azole antifungal drugs are commonly used to treat vulvovaginal candidiasis (VVC). The nephrotoxicity and developmental toxicity of azole drugs have not been systematically analyzed in the real world. We used the FDA Adverse Event Reporting System (FAERS) to investigate the adverse events (AEs) associated with imidazole therapy for VVC. FAERS data (from quarter 1 2004 to quarter 3 2022) were retrieved using OpenVigil 2.1, and AEs were retrieved and standardized according to the Medical Dictionary for Regulatory Activities (MedDRA). In the top 10 System Organ Class (SOC), all four drugs have been found to have kidney and urinary system diseases and pregnancy. We found significant signals, including clotrimazole [bladder transitional cell carcinoma, (report odds ratio, ROR = 291.66)], [fetal death, (ROR = 10.28)], ketoconazole[nephrogenic anemia (ROR = 22.1)], [premature rupture of membranes (ROR = 22.91 46.45, 11, 3)], Miconazole[hematuria (ROR = 19.03)], [neonatal sepsis (ROR = 123.71)], [spontaneous abortion (ROR = 5.98)], Econazole [acute kidney injury (ROR = 4.41)], [spontaneous abortion (ROR = 19.62)]. We also discovered new adverse reactions that were not reported. Therefore, when using imidazole drugs for treatment, it is necessary to closely monitor the patient's renal function, pay attention to the developmental toxicity of the fetus during pregnancy, and be aware of potential adverse reactions that may occur.

Abstract The bulk photovoltaic effect (BPVE) originating from spontaneous charge polarizations can reach high conversion efficiency exceeding the Shockley-Queisser limit. Emerging van der Waals (vdW) heterostructures provide the ideal platform for BPVE due to interfacial interactions naturally breaking the crystal symmetries of the individual constituents and thus inducing charge polarizations. Here, we show an approach to obtain ultrafast BPVE by taking advantage of dual interfacial polarizations in vdW heterostructures. While the in-plane polarization gives rise to the BPVE in the overlayer, the charge carrier transfer assisted by the out-of-plane polarization further accelerates the interlayer electronic transport and enhances the BPVE. We illustrate the concept in MoS2/black phosphorus heterostructures, where the experimentally observed intrinsic BPVE response time achieves 26 ps, orders of magnitude faster than that of conventional non-centrosymmetric materials. Moreover, the heterostructure device possesses an extrinsic response time of approximately 2.2 ns and a bulk photovoltaic coefficient of 0.6 V−1, which is among the highest values for vdW BPV devices reported so far. Our study thus points to an effective way of designing ultrafast BPVE for high-speed photodetection.

Abstract Artificial intelligence (AI) holds immense promise for K-12 education, yet understanding the factors influencing students’ engagement with AI courses remains a challenge. This study addresses this gap by extending the technology acceptance model (TAM) to incorporate cognitive factors such as AI intrinsic motivation (AIIM), AI readiness (AIRD), AI confidence (AICF), and AI anxiety (AIAX), alongside human–computer interaction (HCI) elements like user interface (UI), content (C), and learner-interface interactivity (LINT) in the context of using generative AI (GenAI) tools. By including these factors, an expanded model is presented to capture the complexity of student engagement with AI education. To validate the model, 210 Chinese students spanning grades K7 to K9 participated in a 1 month artificial intelligence course. Survey data and structural equation modeling reveal significant relationships between cognitive and HCI factors and perceived usefulness (PU) and ease of use (PEOU). Specifically, AIIM, AIRD, AICF, UI, C, and LINT positively influence PU and PEOU, while AIAX negatively affects both. Furthermore, PU and PEOU significantly predict students’ attitudes toward AI curriculum learning. These findings underscore the importance of considering cognitive and HCI factors in the design and implementation of AI education initiatives. By providing a theoretical foundation and practical insights, this study informs curriculum development and aids educational institutions and businesses in evaluating and optimizing AI4K12 curriculum design and implementation strategies.

Abstract Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) poses a major threat to the global swine industry, yet effective prevention and control measures remain elusive. This study unveils Nitazoxanide (NTZ) as a potent inhibitor of PRRSV both in vitro and in vivo. Through High-Throughput Screening techniques, 16 potential anti-PRRSV compounds are identified from a library comprising FDA-approved and pharmacopeial drugs. We show that NTZ displays strong efficacy in reducing PRRSV proliferation and transmission in a swine model, alleviating viremia and lung damage. Additionally, Tizoxanide (TIZ), the primary metabolite of NTZ, has been identified as a facilitator of NMRAL1 dimerization. This finding potentially sheds light on the underlying mechanism contributing to TIZ’s role in augmenting the sensitivity of the IFN-β pathway. These results indicate the promising potential of NTZ as a repurposed therapeutic agent for Porcine Reproductive and Respiratory Syndrome (PRRS). Additionally, they provide valuable insights into the antiviral mechanisms underlying NTZ’s effectiveness.

Abstract Functional segmental trachea reconstruction is a critical concern in thoracic surgery, and tissue‐engineered trachea (TET) holds promise as a potential solution. However, current TET falls short in fully restoring physiological function due to the lack of the intricate multi‐tissue structure found in natural trachea. In this research, a multi‐tissue integrated tissue‐engineered trachea (MI‐TET) is successfully developed by orderly assembling various cells (chondrocytes, fibroblasts and epithelial cells) on 3D‐printed PGS bioelastomer scaffolds. The MI‐TET closely resembles the complex structures of natural trachea and achieves the integrated regeneration of four essential tracheal components: C‐shaped cartilage ring, O‐shaped vascularized fiber ring, axial fiber bundle, and airway epithelium. Overall, the MI‐TET demonstrates highly similar multi‐tissue structures and physiological functions to natural trachea, showing promise for future clinical advancements in functional TETs.

Artificially sweetened beverages containing noncaloric monosaccharides were suggested as healthier alternatives to sugar-sweetened beverages. Nevertheless, the potential detrimental effects of these noncaloric monosaccharides on blood vessel function remain inadequately understood. We have established a zebrafish model that exhibits significant excessive angiogenesis induced by high glucose, resembling the hyperangiogenic characteristics observed in proliferative diabetic retinopathy (PDR). Utilizing this model, we observed that glucose and noncaloric monosaccharides could induce excessive formation of blood vessels, especially intersegmental vessels (ISVs). The excessively branched vessels were observed to be formed by ectopic activation of quiescent endothelial cells (ECs) into tip cells. Single-cell transcriptomic sequencing analysis of the ECs in the embryos exposed to high glucose revealed an augmented ratio of capillary ECs, proliferating ECs, and a series of upregulated proangiogenic genes. Further analysis and experiments validated that reduced foxo1a mediated the excessive angiogenesis induced by monosaccharides via upregulating the expression of marcksl1a. This study has provided new evidence showing the negative effects of noncaloric monosaccharides on the vascular system and the underlying mechanisms.

Summary: Previous studies have indicated that various blood cell traits are associated with a higher risk of venous thromboembolism (VTE). However, the causal relationship remains uncertain. We collected data from the China pulmonary thromboembolism registry study and the China pulmonary health study, using propensity score matching and two-sample Mendelian randomization analyses with summary statistics from genome-wide association studies of blood cell traits and VTE in the East Asian population. Our findings revealed that platelet (PLT) count and hemoglobin (Hb) levels were significantly higher in VTE patients compared to the general population (p value