1. Exploring personality traits related to dopamine D2/3 receptor availability in striatal subregions of humans.
- Author
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Caravaggio, Fernando, Fervaha, Gagan, Chung, Jun Ku, Gerretsen, Philip, Nakajima, Shinichiro, Plitman, Eric, Iwata, Yusuke, Wilson, Alan, and Graff-Guerrero, Ariel
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DOPAMINE , *SOCIALIZATION , *IN vivo studies , *STATISTICAL correlation , *SOCIAL desirability scales , *SCALE analysis (Psychology) - Abstract
While several studies have examined how particular personality traits are related to dopamine D 2/3 receptor (D 2/3 R) availability in the striatum of humans, few studies have reported how multiple traits measured in the same persons are differentially related to D 2/3 R availability in different striatal sub-regions. We examined how personality traits measured with the Karolinska Scales of Personality are related to striatal D 2/3 R availability measured with [ 11 C]-raclopride in 30 healthy humans. Based on previous the literature, five personality traits were hypothesized to be most likely related to D 2/3 R availability: impulsiveness, monotony avoidance, detachment, social desirability, and socialization. We found self-reported impulsiveness was negatively correlated with D 2/3 R availability in the ventral striatum and globus pallidus. After controlling for age and gender, monotony avoidance was also negatively correlated with D 2/3 R availability in the ventral striatum and globus pallidus. Socialization was positively correlated with D 2/3 R availability in the ventral striatum and putamen. After controlling for age and gender, the relationship between socialization and D 2/3 R availability in these regions survived correction for multiple comparisons ( p -threshold=.003). Thus, within the same persons, different personality traits are differentially related to in vivo D 2/3 R availability in different striatal sub-regions. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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