1. Severe Acute Respiratory Syndrome Coronavirus 2 Antigens as Targets of Antibody Responses.
- Author
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Ogata AF, Lazarovits R, Uwamanzu-Nna A, Gilboa T, Cheng CA, and Walt DR
- Subjects
- Antibodies, Viral, Antibody Formation, Child, Humans, Immunity, Humoral, COVID-19, SARS-CoV-2
- Abstract
Humoral immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during acute infection and convalescence has been widely studied since March 2020. In this review, the authors summarize literature on humoral responses to SARS-CoV-2 antigens with a focus on spike, nucleocapsid, and the receptor-binding domain as targets of antibody responses. They highlight serologic studies during acute SARS-CoV-2 infection and discuss the clinical relevance of antibody levels in COVID-19 progression. Antibody responses in pediatric COVID-19 patients are also reviewed. Finally, the authors discuss antibody responses during convalescence and their role in protection from SARS-CoV-2 reinfection., Competing Interests: Disclosure D.R. Walt has a financial interest in Quanterix Corporation, a company that develops an ultrasensitive digital immunoassay platform. He is an inventor of the Simoa technology, founder of the company, and serves on its Board of Directors. Dr D.R. Walt’s interests were reviewed and are managed by Brigham and Women’s Hospital and Partners HealthCare in accordance with their conflict-of-interest policies., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2022
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